[Transitory global amnesia].

The authors studied 18 cases of transient global amnesia, a syndrome occurring in middle age, characterized by a sudden memory loss of recent events and transient inability to acquire new knowledge, while consciousness and personal identity are preserved. Chemical and laboratory findings indicates that TGA is probably due to transient ischemia in the temporal lobe and hippocampus

Acute disseminated encephalomyelitis after SARS-CoV-2 infection

Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune disease of the CNS that often after viral infections and mainly affecting children. ADEM is characterized by the onset of multifocal neurologic symptoms, encephalopathy, with brain MRI showing demyelinating abnormalities in the acute phase.(1) Coronavirus disease 2019 (COVID-19) is a novel entity caused by the pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is characterized by influenza-like symptoms, pneumonia, and in severe cases respiratory insufficiency.(2) Many neurologic complications occurring in patients with COVID-19 have been described,(3) and it has been hypothesized that, in some cases, SARS-CoV-2 might exhibit a neurotropic behavior.(4

Tailoring Water-Based Graphite Conductive Ink Formulation for Enzyme Stencil-Printing: Experimental Design to Enhance Wearable Biosensor Performance

Herein, we report for the first time an experimental design-based approach to develop water-based graphite conductive ink containing enzymes and redox mediators to obtain fully printed wearable biosensors for lactate and glucose monitoring. The experimental design encompasses both electrochemical parameters, such as electroactive area and electron transfer rate constant, and rheological parameters, including elastic (G′) and viscous (G′′) moduli where G′′/G′ is expressed as tanδ. Notably, the printed electrodes exhibited an electroactive area AEA of 3.95 ± 0.31 cm2 and a roughness factor, ρ, of 43.8, which is 50 times higher than those of commercially available screen-printed electrodes. Furthermore, lactate oxidase and glucose oxidase are integrated within water-based graphite conductive ink to obtain enzyme-based inks: enzyme-ink (E-INK), to detect lactate, and enzyme mediator-ink (EM-INK), to detect glucose. The resulting biosensors demonstrated high sensitivity and low limit of detection 3.3 μA mM-1 and 0.3 ± 0.1 μM (ferricyanide as electron mediator), and 4.3 μA mM-1 and 3 ± 1 μM, for E-INK and EM-INK, respectively. The biosensors also exhibited excellent selectivity, maintaining their storage stability, with approximately 80-90% of the initial signal retained after 90 days. Overall, this promising system holds potential to be utilized as a flexible and wearable biosensor. Its use of biocompatible water-based inks makes it suitable for applications in sports medicine and remote clinical care