The genome of Roselle's flesh fly Sarcophaga (Helicophagella) rosellei (Böttcher, 1912)

We present a genome assembly from an individual male Sarcophaga rosellei (Roselle's flesh fly; Arthropoda; Insecta; Diptera; Sarcophagidae). The genome sequence is 541 megabases in span. Most of the assembly is scaffolded into six chromosomal pseudomolecules, with the X sex chromosome assembled. The mitochondrial genome has also been assembled and is 19.5 kilobases in length. Gene annotation of this assembly on Ensembl has identified 15,437 protein coding genes

The genome sequence of the lesser worm flesh fly, Sarcophaga (Sarcophaga) subvicina

We present a genome assembly from an individual male Sarcophaga subvicina (the lesser worm flesh fly; Arthropoda; Insecta; Diptera; Sarcophagidae). The genome sequence is 71 megabases in span. Most of the assembly (95.91%) is scaffolded into six chromosomal pseudomolecules, with the X sex chromosome assembled. The mitochondrial genome has also been assembled and is 16.7 kilobases in length. Gene annotation of this assembly on Ensembl identified 16,793 protein coding genes

Designing Participatory AI: Creative Professionals’ Worries and Expectations about Generative AI

Generative AI, i.e., the group of technologies that automaticallygenerate visual or written content based on text prompts, has un-dergone a leap in complexity and become widely available withinjust a few years. Such technologies potentially introduce a massivedisruption to creative fields. This paper presents the results of aqualitative survey ( = 23) investigating how creative professionalsthink about generative AI. The results show that the advancementof these AI models prompts important reflections on what definescreativity and how creatives imagine using AI to support theirworkflows. Based on these reflections, we discuss how we mightdesign participatory AI in the domain of creative expertise withthe goal of empowering creative professionals in their present andfuture coexistence with AI

Intravenous Dofetilide, a Class III Antiarrhythmic Agent, for the Termination of Sustained Atrial Fibrillation or Flutter

AbstractObjectives. This study sought to determine the safety and efficacy of a single bolus of intravenous dofetilide, a pure class III antiarrhythmic agent, for the termination of sustained atrial fibrillation or flutter.Background. Dofetilide is a highly selective blocker of the rapid component of the delayed rectifier current causing action potential prolongation. These effects, and preliminary clinical data, suggest that it may be effective in the treatment of atrial fibrillation and flutter.Methods. Ninety-one patients with sustained atrial fibrillation (75 patients) or flutter (16 patients) were entered into a double-blind, randomized multicenter study of one of two doses of dofetilide (4 or 8 μg/kg body weight) or placebo.Results. Dofetilide effectively terminated the arrhythmia in 31% of patients receiving 8 μg/kg, a statistically significant difference from those receiving 4 μg/kg (conversion rate 12.5%, p < 0.05) or placebo (no conversion, p < 0.01). Patients with atrial flutter had a greater response to dofetilide (54% conversion rate) than those with atrial fibrillation (14.5% conversion rate, p < 0.001).Conclusions. Intravenous dofetilide can convert sustained atrial fibrillation or flutter to sinus rhythm. However, its efficacy is greater in flutter—a response that contrasts with the poorer response seen with class I agents. This finding potentially represents an important advance in the pharmacologic termination of atrial flutter.(J Am Coll Cardiol 1997;29:385–90

Nucleosynthetic Yields from "Collapsars"

The "collapsar" engine for gamma-ray bursts invokes as its energy source the failure of a normal supernova and the formation of a black hole. Here we present the results of the first three-dimensional simulation of the collapse of a massive star down to a black hole, including the subsequent accretion and explosion. The explosion differs significantly from the axisymmetric scenario obtained in two-dimensional simulations; this has important consequences for the nucleosynthetic yields. We compare the nucleosynthetic yields to those of hypernovae. Calculating yields from three-dimensional explosions requires new strategies in post-process nucleosynthesis; we discuss NuGrid's plan for three-dimensional yields.Comment: To appear in the Conference Proceedings for the "10th Symposium on Nuclei in the Cosmos (NIC X)", July 27 - August 1 2008, Mackinack Island, Michigan, US

Difficulties in Probing Nuclear Physics: A Study of 44^{44}Ti and 56^{56}Ni

The nucleosynthetic yield from a supernova explosion depends upon a variety of effects: progenitor evolution, explosion process, details of the nuclear network, and nuclear rates. Especially in studies of integrated stellar yields, simplifications reduce these uncertainties. But nature is much more complex, and to actually study nuclear rates, we will have to understand the full, complex set of processes involved in nucleosynthesis. Here we discuss a few of these complexities and detail how the NuGrid collaboration will address them.Comment: To appear in the Conference Proceedings for the "10th Symposium on Nuclei in the Cosmos (NIC X)", July 27 - August 1 2008, Mackinack Island, Michigan, US