Instanton Contribution to the Proton and Neutron Electric Form Factors

We study the instanton contribution to the proton and neutron electric form factors. Using the single instanton approximation, we perform the calculations in a mixed time-momentum representation in order to obtain the form factors directly in momentum space. We find good agreement with the experimentally measured electric form factor of the proton. For the neutron, our result falls short of the experimental data. We argue that this discrepancy is due to the fact that we neglect the contribution of the sea quarks. We compare to lattice calculations and a relativistic version of the quark-diquark model.Comment: 8 pages, 5 figures, updated references, to appear in Phys. Lett.

Quantum Diffusive Dynamics of Macromolecular Transitions

We study the role of quantum fluctuations of atomic nuclei in the real-time dynamics of non-equilibrium macro-molecular transitions. To this goal we introduce an extension of the Dominant Reaction Pathways (DRP) formalism, in which the quantum corrections to the classical overdamped Langevin dynamics are rigorously taken into account to order h^2 . We first illustrate our approach in simple cases, and compare with the results of the instanton theory. Then we apply our method to study the C7_eq to C7_ax transition of alanine dipeptide. We find that the inclusion of quantum fluctuations can significantly modify the reaction mechanism for peptides. For example, the energy difference which is overcome along the most probable pathway is reduced by as much as 50%.Comment: Final version, to appear in the Journal of Chemical Physic

Investigating Biological Matter with Theoretical Nuclear Physics Methods

The internal dynamics of strongly interacting systems and that of biomolecules such as proteins display several important analogies, despite the huge difference in their characteristic energy and length scales. For example, in all such systems, collective excitations, cooperative transitions and phase transitions emerge as the result of the interplay of strong correlations with quantum or thermal fluctuations. In view of such an observation, some theoretical methods initially developed in the context of theoretical nuclear physics have been adapted to investigate the dynamics of biomolecules. In this talk, we review some of our recent studies performed along this direction. In particular, we discuss how the path integral formulation of the molecular dynamics allows to overcome some of the long-standing problems and limitations which emerge when simulating the protein folding dynamics at the atomistic level of detail.Comment: Prepared for the proceedings of the "XII Meeting on the Problems of Theoretical Nuclear Physics" (Cortona11

Fluctuations in the Ensemble of Reaction Pathways

The dominant reaction pathway (DRP) is a rigorous framework to microscopically compute the most probable trajectories, in non-equilibrium transitions. In the low-temperature regime, such dominant pathways encode the information about the reaction mechanism and can be used to estimate non-equilibrium averages of arbitrary observables. On the other hand, at sufficiently high temperatures, the stochastic fluctuations around the dominant paths become important and have to be taken into account. In this work, we develop a technique to systematically include the effects of such stochastic fluctuations, to order k_B T. This method is used to compute the probability for a transition to take place through a specific reaction channel and to evaluate the reaction rate