11 research outputs found
Il supporto psicologico e la preparazione all'esame endoscopico del bambino e dell'adolescente
Patologie gastroeneteriche su base immunitaria in giovani affetti da diabete insulinodipendente.
Aspects immunohistochimiques et allergologiques de l'hyperplasie nodulaire lymphoide chez l'enfant.
Valutazione immunoistochimica di biopsie intestinali in bambini con allergia alimentare.
Studio con immunofluorescenza di biopsie intestinali in individui affetti da allergia alimentare. Risultati preliminari
Gastric parietal cell autoantibodies in children with insulin-dependent diabetes mellitus | [ANTICORPS ANTIESTOMAC ET GASTRITE AU COURS DU DIABETE INSULINO-DEPENDANT DE L'ENFANT]
Background. Adult patients with insulin-dependent diabetes mellitus frequently also show gastric disturbances. Knowledge of the prevalence of such abnormalities in children with insulin-dependent diabetes and the predictive value of anti-gastric parietal cell antibodies in blood may be of practical importance. Patients and methods. 68 patients (29 boys and 39 girls), aged from 5 yr 2 mo to 19 yr 10 mo, and treated for insulin-dependent diabetes from 1 mo to 14 yr 6 mo, were included in the study. Fasting blood concentrations of gastrin (G), pepsinogen (PG1), anti-gastric parietal cell antibodies (PCA) were measured. Fiberoptic endosoopy and biopsy of the gastroduodenal mucosa were pertormed in PCA + patients and biopsy samples were examined for Helicobacter pylori (HP). Results. 12 patients were PCA+; 3 of them had blood gastrin levels above 104 pg/ml and 4 had blood pepsinogen levels 24 ng/ml. Histologically, 3 patients had chronic diffuse gastritis (2 were HP+); 2 had chronic gastritis restricted to the antro-pylorio area (both were HP+); 3 had follicular lymphoid hyperplasia (without HP) and 4 had normal mucosa (without HP). Conclusion. The presence of PCA can predict the risk of chronic gastritis, possibly auto-immune in origin, in children with insulin-dependent diabetes
Anti-gastric antibodies and gastritis in insulin-dependent diabetes in children.
Adult patients with insulin-dependent diabetes mellitus frequently also show gastric disturbances. Knowledge of the prevalence of such abnormalities in children with insulin-dependent diabetes and the predictive value of anti-gastric parietal cell antibodies in blood may be of practical importance.
PATIENTS AND METHODS:
68 patients (29 boys and 39 girls), aged from 5 yr 2 mo to 19 yr 10 mo, and treated for insulin-dependent diabetes from 1 mo to 14 yr 6 mo, were included in the study. Fasting blood concentrations of gastrin (G), pepsinogen (PG1), anti-gastric parietal cell antibodies (PCA) were measured. Fiberoptic endoscopy and biopsy of the gastroduodenal mucosa were performed in PCA+ patients and biopsy samples were examined for Helicobacter pylori (HP).
RESULTS:
12 patients were PCA+; 3 of them had blood gastrin levels above 104 pg/ml and 4 had blood pepsinogen levels 24 ng/ml. Histologically, 3 patients had chronic diffuse gastritis (2 were HP+); 2 had chronic gastritis restricted to the antro-pyloric area (both were HP+); 3 had follicular lymphoid hyperplasia (without HP) and 4 had normal mucosa (without HP).
CONCLUSION:
The presence of PCA can predict the risk of chronic gastritis, possibly auto-immune in origin, in children with insulin-dependent diabetes