From the visual book to the WEB book : the importance of design

This paper presents the results of two studies into electronic book production. The Visual book study explored the importance of the visual component of the book metaphor for the production of more effective electronic books, while the WEB book study took the findings of the Visual book and applied them to the production of books for publication on the World Wide Web (WWW). Both studies started from an assessment of which kinds of paper book are more suitable for translation into electronic form. Both also identified publications which are meant to be used for reference rather than those which are read sequentially, and usually in their entirety. This group includes scientific publications and textbooks which were both used as the target group for the Visual book and the WEB book experiments. In this paper we discuss the results of the two studies and how they could influence the design and production of more effective electronic books

The WEB Book experiments in electronic textbook design

This paper describes a series of three evaluations of electronic textbooks on the Web, which focused on assessing how appearance and design can affect users' sense of engagement and directness with the material. The EBONI Project's methodology for evaluating electronic textbooks is outlined and each experiment is described, together with an analysis of results. Finally, some recommendations for successful design are suggested, based on an analysis of all experimental data. These recommendations underline the main findings of the evaluations: that users want some features of paper books to be preserved in the electronic medium, while also preferring electronic text to be written in a scannable style

PENG: integrated search of distributed news archives

The PENG system is intended to provide an integrated and personalized environment for news professionals, providing functionalities for filtering, distributed retrieval, and a flexible interface environment for the display and manipulation of news materials. In this paper we review the progress and results of the PENG system to date, and describe in detail the document filtering part of the system, which is designed to gather and filter documents to user profiles. The current architecture will be described, along with some of the main issues which have so far been found in it's development

Probing dissipation mechanisms in BL Lac jets through X-ray polarimetry

The dissipation of energy flux in blazar jets plays a key role in the acceleration of relativistic particles. Two possibilities are commonly considered for the dissipation processes, magnetic reconnection -- possibly triggered by instabilities in magnetically-dominated jets -- , or shocks -- for weakly magnetized flows. We consider the polarimetric features expected for the two scenarios analyzing the results of state-of-the-art simulations. For the magnetic reconnection scenario we conclude, using results from global relativistic MHD simulations, that the emission likely occurs in turbulent regions with unstructured magnetic fields, although the simulations do not allow us to draw firm conclusions. On the other hand, with local particle-in-cell simulations we show that, for shocks with a magnetic field geometry suitable for particle acceleration, the self-generated magnetic field at the shock front is predominantly orthogonal to the shock normal and becomes quasi-parallel downstream. Based on this result we develop a simplified model to calculate the frequency-dependent degree of polarization, assuming that high-energy particles are injected at the shock and cool downstream. We apply our results to HBLs, blazars with the maximum of their synchrotron output at UV-soft X-ray energies. While in the optical band the predicted degree of polarization is low, in the X-ray emission it can ideally reach 50\%, especially during active/flaring states. The comparison between measurements in the optical and in the X-ray band made during active states (feasible with the planned {\it IXPE} satellite) are expected to provide valuable constraints on the dissipation and acceleration processes.Comment: 9 pages, 6 figures, accepted for publication by MNRA

Using a task-based approach in evaluating the usability of BoBIs in an e-book environment

This paper reports on a usability evaluation of BoBIs (Back-of-the-book Indexes) as searching and browsing tools in an e-book environment. This study employed a task-based approach and within-subject design. The retrieval performance of a BoBI was compared with a ToC and Full-Text Search tool in terms of their respective effectiveness and efficiency for finding information in e-books. The results demonstrated that a BoBI was significantly more efficient (faster) and useful compared to a ToC or Full-Text Search tool for finding information in an e-book environment

University of Strathclyde at TREC HARD

The motivation behind the University of Strathclyde's approach to this years HARD track was inspired from previous experiences by other participants, in particular research by [1], [3] and [4]. A running theme throughout these papers was the underlying hypothesis that a user's familiarity in a topic (i.e. their previous experience searching a subject), will form the basis for what type or style of document they will perceive as relevant. In other words, the user's context with regards to their previous search experience will determine what type of document(s) they wish to retrieve

Optical spectroscopic observations of gamma-ray blazar candidates II. The 2013 KPNO campaign in the Northern Hemisphere

We recently started a systematic search of low-energy counterparts of the unidentified gamma-ray sources (UGSs) listed in the Fermi-Large Area Telescope (LAT) First Source Catalog (1FGL) and the Fermi-LAT 2-Year Source Catalog (2FGL).} The main goal of our investigation is to find active galaxies belonging to the blazar class that lie within the positional uncertainty region of the UGSs and thus could be their potential low-energy counterparts. To achieve our aims, we first adopted several procedures based on the peculiar observational properties of blazars in the radio and in the IR. Then we carried out a follow-up spectroscopic campaign in the optical band to verify the nature of the candidates selected as potential counterparts of the UGSs. Here we present the results of the observations carried out in 2013 in the Northern Hemisphere at Kitt Peak National Observatory (KPNO). Optical spectroscopy is crucial to confirm the nature of the sources and can be used to estimate their redshifts; it will also allow us to test the robustness of our methods when the whole campaign is completed. Here we present the optical spectroscopic observations of 39 sources. Within our sample we found that 6 sources are blazars, candidates to be low-energy counterparts of the UGSs listed in the 2FGL. We confirm that an additional 8 sources, previously classified as active galaxies of uncertain type and associated in the 2FGL, are also all BL Lac objects. Moreover, we also present 20 new spectra for known blazars listed in the Multi-frequency Catalogue of Blazars as having an uncertain redshift and/or being classified as BL Lac candidates. We conclude that our methods for selecting gamma-ray blazar candidates allows us to discover new blazars and increase the list of potential low-energy counterparts for the Fermi UGSs.Comment: 27 pages, 39 figures, 1 table, A&A accepted for publication (pre-proof version

Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids

The fluoroquinolone antimicrobial drug danofloxacin was administered to sheep intravenously (i.v.) and intramuscularly (i.m.) at a dose of 1.25 mg/kg of body weight in a two-period crossover study. The pharmacokinetic properties of danofloxacin in serum, inflamed tissue cage fluid (exudate), and noninflamed tissue cage fluid (transudate) were established by using a tissue cage model. The in vitro and ex vivo activities of danofloxacin in serum, exudate, and transudate against a pathogenic strain of Mannheimia haemolytica were established. Integration of in vivo pharmacokinetic data with the in vitro MIC provided mean values for the area under the curve (AUC)/MIC for serum, exudate, and transudate of 60.5, 85.6, and 45.7 h, respectively, after i.v. dosing and 55.9, 77.9, and 49.1 h, respectively, after i.m. dosing. After i.m. dosing, the maximum concentration/MIC ratios for serum, exudate, and transudate were 10.8, 3.0, and 1.6, respectively. The ex vivo growth inhibition data after i.m. dosing were fitted to the inhibitory sigmoid Emax equation to provide the values of AUC/MIC required to produce bacteriostasis, bactericidal activity, and elimination of bacteria. The respective values for serum were 17.8, 20.2, and 28.7 h, and slightly higher values were obtained for transudate and exudate. It is proposed that use of these data might provide a novel approach to the rational design of dosage schedules.Facultad de Ciencias Veterinaria

Probing shock acceleration in BL Lac jets through X-ray polarimetry: the time-dependent view

Polarimetric measurements, especially if extended at high energy, are expected to provide important insights into the mechanisms underlying the acceleration of relativistic particles in jets. In a previous work we have shown that the polarization of the synchrotron X-ray emission produced by highly energetic electrons accelerated by a mildly relativistic shock carries essential imprints of the geometry and the structure of the magnetic fields in the downstream region. Here we present the extension of our analysis to the non-stationary case, especially suitable to model the highly variable emission of high-energy emitting BL Lacs. We anticipate a large ($\Pi \approx 40\%$), almost time-independent degree of polarization in the hard/medium X-ray band, a prediction soon testable with the upcoming mission {\it IXPE}. The situation in other bands, in particular in the optical, is more complex. A monotonic decrease of the optical degree of polarization is observed during the development of a flare. At later stages $\Pi$ reaches zero and then it starts to increase, recovering large values at late times. The instant at which $\Pi=0$ is marked by a rotation of the polarization angle by $90$ degrees. However, at optical frequencies it is likely that more than one region contributes to the observed emission, potentially making it difficult to detect the predicted behavior.Comment: 11 pages, 9 figures, accepted for publication by MNRA