Transmural Inflammation, Ileitis, and Granulomas at the Time of Proctocolectomy in Patients with Ulcerative Colitis Do Not Predict Future Development of Pouchitis

Background: The most common complication following ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC) is pouchitis. Our study aimed to investigate the relationship between histopathologic findings of ileitis, granuloma, or transmural inflammation on the colectomy specimen of patients with clinically and endoscopically diagnosed UC and the development of pouchitis within the first 2 years after IPAA. Methods: We performed a retrospective cohort study evaluating patients undergoing colectomy with IPAA for UC between January 1, 2004 and December 31, 2016. Bivariate analyses were conducted to evaluate the relationship between clinical factors and the development of pouchitis. We performed multivariate logistic regression to evaluate the relationship between histologic, clinical, and demographic factors at the time of colectomy and subsequent development of pouchitis. Results: Among 626 patients, pouchitis occurred in 246 (39%). Patients with primary sclerosing cholangitis were more likely to develop pouchitis (adjusted odds ratio [aOR] 2.81, 95% confidence interval [CI] 1.02-7.72), as were patients with a family history of inflammatory bowel disease (aOR 1.75, 95% CI 1.11-2.77). Histologic findings of ileitis, granuloma, or transmural inflammation were not associated with an increased odds of developing pouchitis (aOR 0.70, 95% CI 0.45-1.08). Discussion/Conclusion: Patients with ileitis, granulomas, or transmural inflammation at the time of colectomy were not at greater risk for development of pouchitis in the 2 years after IPAA. These pathological findings should not preclude IPAA for UC

Public assembly facility management : principles and practices

Public assembly facility management is increasingly being recognized as a vital and rewarding profession. In order to continually enhance the expertise and professionalism of its members, the IAMM and the IAMM foundation committed substantial financial resources to create a written \u27body of knowledge\u27 with core competencies

Public assembly venue management : sports, entertainment, meeting, and convention venues

Contents: ch. 1 History and Role of Public Assembly Venues -- ch. 2 Venue Ownership and Management -- ch. 3 Venue planning, financing, design, and construction -- ch. 4 Business and financial management -- ch. 5 Booking the Venue -- ch. 6 Marketing--ch. 7 Ticketing-- ch. 8 Ancillary Services and Revenue Sources -- ch. 9 Venue Operations and Services -- ch. 10 Event Management and Services -- ch. 11 Safety and Security -- Appendices -- Appendix A Industry Examples -- Appendix B Contract Components -- Appendix C IAVM continuing education and professional development opportunities-- Appendix D Related Organizations and Associations-- References -- Glossary of terms -- Index

Public assembly facility management : principles and practices

Public assembly facility management is increasingly being recognized as a vital and rewarding profession. In order to continually enhance the expertise and professionalism of its members, the IAMM and the IAMM foundation committed substantial financial resources to create a written \u27body of knowledge\u27 with core competencies

Public assembly venue management : sports, entertainment, meeting, and convention venues

Contents: ch. 1 History and Role of Public Assembly Venues -- ch. 2 Venue Ownership and Management -- ch. 3 Venue planning, financing, design, and construction -- ch. 4 Business and financial management -- ch. 5 Booking the Venue -- ch. 6 Marketing--ch. 7 Ticketing-- ch. 8 Ancillary Services and Revenue Sources -- ch. 9 Venue Operations and Services -- ch. 10 Event Management and Services -- ch. 11 Safety and Security -- Appendices -- Appendix A Industry Examples -- Appendix B Contract Components -- Appendix C IAVM continuing education and professional development opportunities-- Appendix D Related Organizations and Associations-- References -- Glossary of terms -- Index

Public assembly venue management : sports, entertainment, meeting, and convention venues

Contents: ch. 1 History and Role of Public Assembly Venues -- ch. 2 Venue Ownership and Management -- ch. 3 Business and Financial Management -- ch. 4 Booking the Venue -- ch. 5 Marketing and Sales -- ch. 6 Ticketing and Access Management -- ch. 7 Event and Ancillary Revenue Sources -- ch. 8 Venue Operations and Services -- ch. 9 Event Management and Services -- ch. 10 Safety and Security -- Appendices -- Appendix A Industry Examples -- Appendix B Core Competencies -- Appendix C Contract Components -- Appendix D IAVM Continuing Education Opportunities -- Appendix E Related Organizations and Associations -- Glossary -- References -- Index

Using small peptide segments of amyloid-β and humanin to examine their physical interactions

Background: Amyloid fibrils in Alzheimer’s disease are composed of amyloid-β (Aβ) peptides of variant lengths. Humanin (HN), a 24 amino acid residue neuroprotective peptide, is known to interact with the predominant Aβ isoform in the brain, Aβ (1-40). Methods: Here, we constructed smaller segments of Aβ and HN and identified residues in HN important for both HN-HN and HN-Aβ interactions. Peptides corresponding to amino acid residues 5-15 of HN, HN (5-15), HN (5-15, L11S), where Leu11 was replaced with Ser, and residues 17-28 of Aβ, Aβ (17-28), were synthesized and tested for their ability to block formation of the complex between HN and Aβ (1-40). Results: Co-immunoprecipitation and binding kinetics showed that HN (5-15) was more efficient at blocking the complex between HN and Aβ (1-40) than either HN (5-15, L11S) or Aβ (17-28). Binding kinetics of these smaller peptides with either full-length HN or Aβ (1-40) showed that HN (5-15) was able to bind either Aβ (1-40) or HN more efficiently than HN (5-15, L11S) or Aβ (17-28). Compared to full-length HN, however, HN (5-15) bound Aβ (1-40) with a weaker affinity suggesting that while HN (5-15) binds Aβ, other residues in the full length HN peptide are necessary for maximum interactions. Conclusion: L11 was more important for interactions with Aβ (1-40) than with HN. Aβ (17-28) was relatively ineffective at binding to either Aβ (1-40) or HN. Moreover, HN, and the smaller HN (5-15), HN (5-15 L11S), and Aβ (17-28) peptides, had different effects on regulating Aβ (1-40) aggregation kinetics