Effect of Sida corymbosa leaf extract on serum uric acid, urea and creatinine levels of alloxan-induced diabetic albino wistar rats

This study was designed to investigate the effect of Sida corymbosa (SC) leaf extract on serum uric acid, urea and creatinine levels in alloxan induced diabetic albino wistar rats. A total of 30 albino wistar rats each weighing 100g were assembled and divided into three groups (A-C) consisting of 10 rats in each group. Group A received SC treatment, B did not receive SC treatment, while group C served as the control group. 400mg/kg of aqueous extract of SC leaf was administered orally to the rats in group A but not in group B, while group C received only water for 7 days. Blood samples were collected into plain containers for estimation of serum uric acid, urea and creatinine. Serum uric acid, urea and creatinine were analyzed using Uricase, Urease-Berthlot and Jaffe Slot Alkaline picrate methods respectively. Results showed a significant increase in the mean serum levels of uric acid, urea and creatinine after SC treatment, when compared to the pre- treatment status. Similarly, there was a significant decrease in the mean weight of the rats after SC administration. Therefore, SC may have potential harmful effect on the kidney.Keywords: Sida corymbosa, Kidney, Urea, Uric Acid, Creatinine