Digitalisierung und Mittelstand: Eine Metastudie

Der Mittelstand bildet das Rückgrat der deutschen Wirtschaft. Damit diese auch künftig international wettbewerbsfähig bleibt, bietet die Digitalisierung den Unternehmen eine große Chance, Prozesse zu optimieren, neue Geschäftsmodelle zu erarbeiten und neue Märkte zu erschließen. In diesem Zusammenhang sind digitale Technologien für die Weiterentwicklung der ökonomischen und technologischen Leistungsfähigkeit Deutschlands entscheidend. Die vorliegende IW-Analyse untersucht auf Basis von 46 Studien aus den Jahren 2013 bis 2016 den Status quo der Digitalisierung im deutschen Mittelstand, fasst Gemeinsamkeiten und Unterschiede der Studien zusammen und erläutert Chancen und Potenziale sowie Hemmnisse und Risiken der Digitalisierung. Ausgehend von dieser Metaanalyse werden Handlungsempfehlungen für die Politik abgeleitet, die dazu beitragen sollen, die Digitalisierung im Mittelstand so voranzutreiben, dass sie den Wettbewerbsstandort Deutschland nachhaltig stärkt.Germany's small and medium-sized enterprises, known collectively as the Mittelstand, form the backbone of the German economy. Digitalization offers such companies a golden opportunity to optimize processes, develop new business models and open up new markets, so ensuring that they remain internationally competitive. Digital technologies are thus crucial to the ongoing development of Germany's economic and technological capabilities. Based on 46 studies conducted between 2013 to 2016, the present IW analysis examines the current level of digitalization in the Mittelstand. It summarizes what the studies have in common and where they differ and explains both the opportunities and potential and the obstacles and risks emanating from digitalization. From this meta-analysis the authors derive policy recommendations designed to boost digitalization in the Mittelstand and thus enhance Germany's long-term position as a competitive location for industrial investment

Exploring Correlation Methods to Determine QCD beta-Functions on the Lattice

We investigate -- as an alternative to usual Monte Carlo Renormalization Group methods -- the feasibility of extracting QCD beta-functions directly from a lattice analysis of correlations between the action and Wilson loops. We test this correlation technique numerically in four dimensional SU(2) gauge theory, on a 16^4 lattice at beta = 2.5 and find very promising results.Comment: 12 pages, 2 Figure

Block Spin Effective Action for 4d SU(2) Finite Temperature Lattice Gauge Theory

The Svetitsky-Yaffe conjecture for finite temperature 4d SU(2) lattice gauge theory is confirmed by observing matching of block spin effective actions of the gauge model with those of the 3d Ising model. The effective action for the gauge model is defined by blocking the signs of the Polyakov loops with the majority rule. To compute it numerically, we apply a variant of the IMCRG method of Gupta and Cordery.Comment: LaTeX2e, 22 pages, 8 Figure

Can we import quality tools? a feasibility study of European practice assessment in a country with less organised general practice

<p>Abstract</p> <p>Background</p> <p>Quality is on the agenda of European general practice (GP). European researchers have, in collaboration, developed tools to assess quality of GPs. In this feasibility study, we tested the European Practice Assessment (EPA) in a one-off project in Belgium, where general practice has a low level of GP organisation.</p> <p>Methods</p> <p>A framework for feasibility analysis included describing the recruiting of participants, a brief telephone study survey among non-responders, organisational and logistic problems. Using field notes and focus groups, we studied the participants' opinions.</p> <p>Results</p> <p>In this study, only 36 of 1000 invited practices agreed to participate. Co-ordination, administrative work, practice visits and organisational problems required several days per practice. The researchers further encountered technical problems, for instance when entering the data and uploading to the web-based server. In subsequent qualitative analysis using two focus groups, most participant GPs expressed a positive feeling after the EPA procedure. In the short period of follow-up, only a few GPs reported improvements after the visit. The participant GPs suggested that follow-up and coaching would probably facilitate the implementation of changes.</p> <p>Conclusion</p> <p>This feasibility study shows that prior interest in EPA is low in the GP community. We encountered a number of logistic and organisational problems. It proved attractive to participants, but it can be augmented by coaching of participants in more than a one-off project to identify and achieve targets for quality improvement. In the absence of commitment of the government, a network of universities and one scientific organisation will offer EPA as a service to training practices.</p

Measurement of Rashba and Dresselhaus spin-orbit magnetic fields

Spin-orbit coupling is a manifestation of special relativity. In the reference frame of a moving electron, electric fields transform into magnetic fields, which interact with the electron spin and lift the degeneracy of spin-up and spin-down states. In solid-state systems, the resulting spin-orbit fields are referred to as Dresselhaus or Rashba fields, depending on whether the electric fields originate from bulk or structure inversion asymmetry, respectively. Yet, it remains a challenge to determine the absolute value of both contributions in a single sample. Here we show that both fields can be measured by optically monitoring the angular dependence of the electrons' spin precession on their direction of movement with respect to the crystal lattice. Furthermore, we demonstrate spin resonance induced by the spin-orbit fields. We apply our method to GaAs/InGaAs quantum-well electrons, but it can be used universally to characterise spin-orbit interactions in semiconductors, facilitating the design of spintronic devices

The Weisweiler passive seismological network: optimised for state-of-the-art location and imaging methods

Passive seismic analyses are a key technology for the exploration and monitoring of subsurface reservoirs. Searching for alternative resources in the framework of the energy transition is creating a surge for identifying as many potential sites as possible suitable for geothermal exploitation. The Lower Rhine Embayment, at the western border of North Rhine-Westphalia in Germany, is an extensional system with a very high potential for geothermal exploitation. The area experiences moderate but continuous natural seismicity. Here, we report on a passive seismic dataset recorded with 48 seismic stations centred at and around Eschweiler-Weisweiler (https://doi.org/10.14470/MO7576467356, Finger et al., 2022). Background seismic noise levels are high at this site due to high levels of anthropogenic noise and thick unconsolidated sedimentary layers. The final station layout is a compromise between targeted network design and suitably quiet locations. We show that the network design allows for the application of state-of-the-art methods including waveform-based source location methods and ambient-noise velocity imaging methods

Expression of survivin detected by immunohistochemistry in the cytoplasm and in the nucleus is associated with prognosis of leiomyosarcoma and synovial sarcoma patients

<p>Abstract</p> <p>Background</p> <p>Survivin, a member of the inhibitor of apoptosis-protein family suppresses apoptosis and regulates cell division. It is strongly overexpressed in the vast majority of cancers. We were interested if survivin detected by immunohistochemistry has prognostic relevance especially for patients of the two soft tissue sarcoma entities leiomyosarcoma and synovial sarcoma.</p> <p>Methods</p> <p>Tumors of leiomyosarcoma (n = 24) and synovial sarcoma patients (n = 26) were investigated for their expression of survivin by immunohistochemistry. Survivin expression was assessed in the cytoplasm and the nucleus of tumor cells using an immunoreactive scoring system (IRS).</p> <p>Results</p> <p>We detected a survivin expression (IRS > 2) in the cytoplasm of 20 leiomyosarcomas and 22 synovial sarcomas and in the nucleus of 12 leiomyosarcomas and 9 synovial sarcomas, respectively. There was no significant difference between leiomyosarcoma and synovial sarcoma samples in their cytoplasmic or nuclear expression of survivin. Next, all sarcoma patients were separated in four groups according to their survivin expression in the cytoplasm and in the nucleus: group 1: negative (IRS 0 to 2); group 2: weak (IRS 3 to 4); group 3: moderate (IRS 6 to 8); group 4: strong (IRS 9 to 12). In a multivariate Cox's regression hazard analysis survivin expression detected in the cytoplasm or in the nucleus was significantly associated with overall survival of patients in group 3 (RR = 5.7; P = 0.004 and RR = 5.7; P = 0.022, respectively) compared to group 2 (reference). Patients whose tumors showed both a moderate/strong expression of survivin in the cytoplasm and a moderate expression of survivin in the nucleus (in both compartments IRS ≥ 6) possessed a 24.8-fold increased risk of tumor-related death (P = 0.003) compared to patients with a weak expression of survivin both in the cytoplasm and in the nucleus.</p> <p>Conclusion</p> <p>Survivin protein expression in the cytoplasma and in the nucleus detected by immunohistochemistry is significantly associated with prognosis of leiomyosarcoma and synovial sarcoma patients.</p

Transcript levels of ten caste-related genes in adult diploid males of Melipona quadrifasciata (Hymenoptera, Apidae) - A comparison with haploid males, queens and workers

In Hymenoptera, homozygosity at the sex locus results in the production of diploid males. In social species, these pose a double burden by having low fitness and drawing resources normally spent for increasing the work force of a colony. Yet, diploid males are of academic interest as they can elucidate effects of ploidy (normal males are haploid, whereas the female castes, the queens and workers, are diploid) on morphology and life history. Herein we investigated expression levels of ten caste-related genes in the stingless bee Melipona quadrifasciata, comparing newly emerged and 5-day-old diploid males with haploid males, queens and workers. In diploid males, transcript levels for dunce and paramyosin were increased during the first five days of adult life, while those for diacylglycerol kinase and the transcriptional co-repressor groucho diminished. Two general trends were apparent, (i) gene expression patterns in diploid males were overall more similar to haploid ones and workers than to queens, and (ii) in queens and workers, more genes were up-regulated after emergence until day five, whereas in diploid and especially so in haploid males more genes were down-regulated. This difference between the sexes may be related to longevity, which is much longer in females than in males