A BIOMECHANICAL STUDY OF TIMING IN BASEBALL BATTING AGAINST A PITCHED FASTBALL: COMPARISON OF BATTING SITUATIONS WITH AND WITHOUT PRIOR KNOWLEDGE OF THE TYPE OF PITCH

The aim of the study was to examine the differences in the timing of the batting motion between a situation in which the batter knew beforehand the type of incoming pitch and a situation in which he did not. Nine pitchers and 9 batters participated in this study. Batters were requested to hit the pitched ball in known-pitch and unknown-pitch situations. A successful trial of the batter was one in which the ball was hit squarely; a failed trial was one that produced a glancing blow. Pitching and batting motions were recorded with video cameras and a motion capture system. In the known-pitch situation, significant positive correlations were found between four batting phases and three pitching phases. The results suggested that the timing strategy of the batting motion in the unknown situation is different from that of the known situation

A BIOMECHANICAL ANALYSIS OF COMPETITIVE AND RECREATIONAL PLAYERS IN RELATION TO THE DARTS THROWING TECHNIQUE

The aim of this study was to clarify the difference of the darts throwing motion (technique) between competitive (CG) and recreational (RG) groups. The darts throwing motions for each group were analyzed using an automatic motion capture system and force platforms. The performance (distance) of CG was statistically superior to RG. Shoulder and elbow joint movement indexes were smaller in CG than in RG. CG threw the dart with the static position that body weight was mostly distributed to the forward leg. However, RG started from the static position that distributed two thirds of body weight on the forward leg, and subsequently threw the dart while transmitting most of the remaining body weight from backward leg to forward leg. It is concluded that CG had the less movement of body segments involved in the darts throwing motion to achieve a high level of performance

A BIOMECHANICAL COMPARISON OF THE CROSSOVER STEP AND JAB STEP TECHNIQUES IN THE PUSHOFF OF BASE STEALING STARTS IN BASEBALL

The aim of this study was to compare the effectiveness of the crossover step (CS) and jab step (JS) start techniques in baseball base stealing. Fourteen varsity fielders participated in the study. An automatic motion capture system and synchronized force platforms were used to analyze the two start techniques, performed at full effort by each individual. No statistical difference was found in the start time (duration of the start phase) between the two techniques. However, the start velocity (forward velocity of the body CG at the end of right leg push-off phase) was significantly larger in JS than in CS. It was found that the difference in the start velocity between the two step techniques comes from the difference in the forward impulse generated by the left leg push-off

A KINEMATIC COMPARISON OF THE DELIVERY MOTIONS OF CATCHERS AND INFIELDERS IN BASEBALL

The aim of this study was to compare the delivery motions of baseball catchers and infielders. Thirteen catchers and 16 infielders participated in the study. 3D analysis was used to analyze the release parameters, the durations of 4 phases, and trunk, pelvis and throwing arm kinematics in the two groups. No statistical difference in ball velocity and angle of release was found between the groups. Of the 45 angular position and angular velocity parameters tested at key instants in the throws, 15 showed significant differences between the groups. The only significant differences in maximum angular velocities and in their times of occurrence were in the maximum pelvis forward rotation angular velocity and in the time of occurrence of the maximum elbow extension angular velocity. These results should be useful for the improvement of baseball throwing motions

6. Heating Structure of Laser-Driven Detonations(<Special Topic Article>New Trend of Sciences with High Energy Lasers)

デトネーションとは,衝撃波とそれに伴う流体加熱領域とが一体となって媒質中を伝播する現象であり,流体加熱機構には化学燃焼,核燃焼,レーザー加熱の3つが知られている.レーザー駆動デトネーションについては,現象は1960年代から知られているものの,詳細はほとんどわかっていない.本章では,大スポット径レーザー照射によって発生させた平面波的なレーザー駆動デトネーションの加熱構造について,最近の実験結果を紹介する

Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses

Background: A Phase I dose escalation first in man study assessed maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and recommended Phase II dose of TP300, a water soluble prodrug of the Topo-1 inhibitor TP3076, and active metabolite, TP3011. &lt;p/&gt;Methods: Eligible patients with refractory advanced solid tumors, adequate performance status, haematologic, renal, and hepatic function. TP300 was given as a 1-hour i.v. infusion 3-weekly and pharmacokinetic (PK) profiles of TP300, TP3076 and TP3011 were analysed. Polymorphisms in CYP2D6, AOX1 and UGT1A1 were studied and DNA strand-breaks measured in peripheral blood mononuclear cells (PBMCs). &lt;p/&gt;Results: 32 patients received TP300 at 1, 2, 4, 6, 8, 10, 12 mg/m2. MTD was 10 mg/m2; DLTs at 12 (2/4 patients) and 10 mg/m2 (3/12) included thrombocytopenia and febrile neutropenia; diarrhea was uncommon. Six patients (five had received irinotecan), had stable disease for 1.5-5 months. TP3076 showed dose proportionality in AUC and Cmax from 1--10 mg/m2. Genetic polymorphisms had no apparent influence on exposure. DNA strand-breaks were detected after TP300 infusion. &lt;p/&gt;Conclusions: TP300 had predictable hematologic toxicity, and diarrhea was uncommon. AUC at MTD is substantially greater than for SN38. TP3076 and TP3011 are equi-potent with SN38, suggesting a PK advantage

Poster Session

International Symposium on Tumor Biology in Kanazawa & Symposium on Drug Discoverry in Academics 2014 [DATE]: January 23(Thu)-24(Fri),2014, [Place]:Kanazawa Excel Hotel Tpkyu, Kanazawa, Japan, [Organizers]:Kanazawa Association of Tumor Biologists / Cancer Research Institute, Kanazawa Universit

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection