Additional file 1: of Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD

Table S1. Spearman’s correlation analysis between CT parameters and sputum markers (all sputum samples). Table S2. CT parameters in subjects according to sputum Bacterial PCR Detection. Figure S1. Scatterplots of (A) %LAA<− 950 against Pi10 (rho − 0.36***, p < 0.001) (B) E/I MLD against Pi10 (rho 0.18*, p 0.045) (C) %LAA<− 950 against E/I MLD (rho 0.47***, p < 0.001). (DOCX 74 kb

Additional file 2: of Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD

Table S1. Radiological findings at exacerbation. Table S2. Exacerbation treatment stratified by the presence or absence of radiographic pneumonic infiltrate. Table S3. Bacterial identification by culture and PCR in all exacerbation sputum samples and those exacerbation sputum samples with fewer than 30% squamous cells (considered high quality). Table S4. Bacterial and viral identification at exacerbation by culture (bacteria) and PCR (bacteria/viral). Table S5. Levels of inflammatory markers at paired stable and exacerbation visits. Table S6. Changes in levels of serum inflammatory markers between stable (pre-exacerbation) and exacerbation samples. Table S7. Levels of serum inflammatory markers at paired stable and exacerbation visits. The occurrence of the first infiltrate-associated exacerbation where available was prioritised, or first non-infiltrative exacerbation if not (subjects are therefore only represented once). Table S8. Lung function changes between nearest stable-state and exacerbation visits, stratified by the presence/absence of pneumonic infiltrate. Figure S1. The proportion of bacterial positive sputum samples at exacerbation by both culture and PCR. Figure S2. The lung microbiome (phylum) of exacerbations stratified by the presence or absence of pneumonic infiltrate. Figure S3. Area under the receiver operator curve analysis for CRP, fibrinogen and neutrophil count. (DOCX 232 kb