Reference to index of records of the diary of William Gore Elliston 1829 -1864

Transcript and extracts from W. G. Elliston's diaries 1829 -1864. Extracts selected by J.N.D. Harrison for his proposed book: "Shades of Elliston

Reference to the index of some late nineteenth/early twentieth century newspapers.

Small collection of mainly Tasmanian newspapers such as 'Colonial Times' and the 'Tasmanian'. Also 'The Mercury' and 'The Examiner', from 1843-1975, covering some important topics such as when the armistice was signed by the Germans and the Hobart Bridge disaster of 1975

12 Museum Theorists at Play

Introduction by Lauren Appel1. Learning by Do-weyan, by Marian Howard, with Nicole Ferrin2: Dewey Defines Himself and Education, by David Vining 3. Benjamin Ives Gilman: Arts in People’s Lives, by Katherine Hillman 4. John Cotton Dana: The Social Construction of Museums, by Marissa Corwin 5. Piaget in the Art Museum: Constructing Knowledge Through Active Engagement, by Berry Stein 6. Lev Vygotsky: The Social Aspects of Learning, by Nicole Keller 7. Paulo Freire: Literacy, Democracy, and Context, by Nicole Keller 8. Maxine Greene: Aesthetic Education, by Lauren Appel 9. Howard Gardner and Multiple Intelligence Theory: A Practical Application of Entry Points in Museum Programming, by Bill Elliston 10. Mihaly Csikszentmihalyi: Finding the Flow, by David Bowles 11. George Hein: Metaconstructivist, by Lauren Appel 12. David Carr: A Poetics of Questions, by Tiffany Reedy 13. David Sobel: Please in My Backyard, by Kathryn Eliza Harris 14. Connecting the Dots, by Liat Olenickhttps://educate.bankstreet.edu/faculty-staff/1009/thumbnail.jp

Comparative Transcriptional Network Modeling of Three PPAR-α/γ Co-Agonists Reveals Distinct Metabolic Gene Signatures in Primary Human Hepatocytes

Aims: To compare the molecular and biologic signatures of a balanced dual peroxisome proliferator-activated receptor (PPAR)-α/γ agonist, aleglitazar, with tesaglitazar (a dual PPAR-α/γ agonist) or a combination of pioglitazone (Pio; PPAR-γ agonist) and fenofibrate (Feno; PPAR-α agonist) in human hepatocytes. Methods and Results: Gene expression microarray profiles were obtained from primary human hepatocytes treated with EC50-aligned low, medium and high concentrations of the three treatments. A systems biology approach, Causal Network Modeling, was used to model the data to infer upstream molecular mechanisms that may explain the observed changes in gene expression. Aleglitazar, tesaglitazar and Pio/Feno each induced unique transcriptional signatures, despite comparable core PPAR signaling. Although all treatments inferred qualitatively similar PPAR-α signaling, aleglitazar was inferred to have greater effects on high- and low-density lipoprotein cholesterol levels than tesaglitazar and Pio/Feno, due to a greater number of gene expression changes in pathways related to high-density and low-density lipoprotein metabolism. Distinct transcriptional and biologic signatures were also inferred for stress responses, which appeared to be less affected by aleglitazar than the comparators. In particular, Pio/Feno was inferred to increase NFE2L2 activity, a key component of the stress response pathway, while aleglitazar had no significant effect. All treatments were inferred to decrease proliferative signaling. Conclusions: Aleglitazar induces transcriptional signatures related to lipid parameters and stress responses that are unique from other dual PPAR-α/γ treatments. This may underlie observed favorable changes in lipid profiles in animal and clinical studies with aleglitazar and suggests a differentiated gene profile compared with other dual PPAR-α/γ agonist treatments

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

<p>Abstract</p> <p>Background</p> <p>Calorie restriction (CR) produces a number of health benefits and ameliorates diseases of aging such as type 2 diabetes. The components of the pathways downstream of CR may provide intervention points for developing therapeutics for treating diseases of aging. The NAD⁺-dependent protein deacetylase SIRT1 has been implicated as one of the key downstream regulators of CR in yeast, rodents, and humans. Small molecule activators of SIRT1 have been identified that exhibit efficacy in animal models of diseases typically associated with aging including type 2 diabetes. To identify molecular processes induced in the liver of mice treated with two structurally distinct SIRT1 activators, SIRT501 (formulated resveratrol) and SRT1720, for three days, we utilized a systems biology approach and applied Causal Network Modeling (CNM) on gene expression data to elucidate downstream effects of SIRT1 activation.</p> <p>Results</p> <p>Here we demonstrate that SIRT1 activators recapitulate many of the molecular events downstream of CR <it>in vivo</it>, such as enhancing mitochondrial biogenesis, improving metabolic signaling pathways, and blunting pro-inflammatory pathways in mice fed a high fat, high calorie diet.</p> <p>Conclusion</p> <p>CNM of gene expression data from mice treated with SRT501 or SRT1720 in combination with supporting <it>in vitro </it>and <it>in vivo </it>data demonstrates that SRT501 and SRT1720 produce a signaling profile that mirrors CR, improves glucose and insulin homeostasis, and acts via SIRT1 activation <it>in vivo</it>. Taken together these results are encouraging regarding the use of small molecule activators of SIRT1 for therapeutic intervention into type 2 diabetes, a strategy which is currently being investigated in multiple clinical trials.</p

Reading Stratigraphical Woodscapes in Thomas Hardy's The Woodlanders

In The Woodlanders (1887), Hardy uses the texture of Hintock woodlands as more than description: it is a terrain of personal association and local history, a text to be negotiated in order to comprehend the narrative trajectory. However, upon closer analysis of these arboreal environs, it is evident that these woodscapes are simultaneously self-contained and multi-layered in space and time. This essay proposes that through this complex topographical construction, Hardy invites the reader to read this text within a physical and notional stratigraphical framework. This framework shares similarities with William Gilpin's picturesque viewpoint and the geological work of Gideon Mantell: two modes of vision that changed the observation of landscape in the eighteenth and nineteenth centuries. This comparative discussion at once reviews the perception of the arboreal prospect in nineteenth-century literary and visual cultures, and also questions the impact of these modes of thought on the woodscapes of The Woodlanders