Low-dimensional Representations of Hyperspectral Data for Use in CRF-based Classification

Probabilistic graphical models have strong potential for use in hyperspectral image classification. One important class of probabilisitic graphical models is the Conditional Random Field (CRF), which has distinct advantages over traditional Markov Random Fields (MRF), including: no independence assumption is made over the observation, and local and pairwise potential features can be defined with flexibility. Conventional methods for hyperspectral image classification utilize all spectral bands and assign the corresponding raw intensity values into the feature functions in CRFs. These methods, however, require significant computational efforts and yield an ambiguous summary from the data. To mitigate these problems, we propose a novel processing method for hyperspectral image classification by incorporating a lower dimensional representation into the CRFs. In this paper, we use representations based on three types of graph-based dimensionality reduction algorithms: Laplacian Eigemaps (LE), Spatial-Spectral Schroedinger Eigenmaps (SSSE), and Local Linear Embedding (LLE), and we investigate the impact of choice of representation on the subsequent CRF-based classifications

Rufus: The Information Sponge

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Successful immune tolerance induction to enzyme replacement therapy in CRIM-negative infantile Pompe disease

PURPOSE: Infantile Pompe disease resulting from a deficiency of lysosomal acid α-glucosidase (GAA) requires enzyme replacement therapy (ERT) with recombinant human GAA (rhGAA). Cross-reactive immunologic material negative (CRIM-negative) Pompe patients develop high-titer antibody to the rhGAA and do poorly. We describe successful tolerance induction in CRIM-negative patients. METHODS: Two CRIM-negative patients with preexisting anti-GAA antibodies were treated therapeutically with rituximab, methotrexate, and gammaglobulins. Two additional CRIM-negative patients were treated prophylactically with a short course of rituximab and methotrexate, in parallel with initiating rhGAA. RESULTS: In both patients treated therapeutically, anti-rhGAA was eliminated after 3 and 19 months. All four patients are immune tolerant to rhGAA, off immune therapy, showing B-cell recovery while continuing to receive ERT at ages 36 and 56 months (therapeutic) and 18 and 35 months (prophylactic). All patients show clinical response to ERT, in stark contrast to the rapid deterioration of their nontolerized CRIM-negative counterparts. CONCLUSION: The combination of rituximab with methotrexate ± intravenous gammaglobulins (IVIG) is an option for tolerance induction of CRIM-negative Pompe to ERT when instituted in the naïve setting or following antibody development. It should be considered in other conditions in which antibody response to the therapeutic protein elicits robust antibody response that interferes with product efficacy