Archaeological Investigations at the Philpott Site, Henry County, Virginia

Research Report No. 19, Research Laboratories of Archaeology, University of North Carolina at Chapel Hill. Reports in this series discuss the findings of archaeological excavations and research projects undertaken by the RLA between 1984 and present

Archaeological Investigations at the Dallas Hylton Site, Henry County, Virginia

Research Report No. 18, Research Laboratories of Archaeology, University of North Carolina at Chapel Hill. Reports in this series discuss the findings of archaeological excavations and research projects undertaken by the RLA between 1984 and present

Archaeological Investigations at the Box Plant Site, Henry County, Virginia

Research Report No. 13, Research Laboratories of Archaeology, University of North Carolina at Chapel Hill. Reports in this series discuss the findings of archaeological excavations and research projects undertaken by the RLA between 1984 and present

Archaeological Investigations at the Gravely Site, Henry County, Virginia

Research Report No. 17, Research Laboratories of Archaeology, University of North Carolina at Chapel Hill. Reports in this series discuss the findings of archaeological excavations and research projects undertaken by the RLA between 1984 and present

Archaeological Investigations at the Stockton Site, Henry County, Virginia

Research Report No. 14, Research Laboratories of Archaeology, University of North Carolina at Chapel Hill. Reports in this series discuss the findings of archaeological excavations and research projects undertaken by the RLA between 1984 and present

Archaeological Investigations at the Belmont Site, Henry County, Virginia

Research Report No. 15, Research Laboratories of Archaeology, University of North Carolina at Chapel Hill. Reports in this series discuss the findings of archaeological excavations and research projects undertaken by the RLA between 1984 and present

An evaluation of a series of exercises in functional grammar

Thesis (Ed.M.)--Boston Universit

Archaeological Investigations at the Wells Site, Henry County, Virginia

Research Report No. 16, Research Laboratories of Archaeology, University of North Carolina at Chapel Hill. Reports in this series discuss the findings of archaeological excavations and research projects undertaken by the RLA between 1984 and present

The Erythropoietin Receptor Stimulates Rapid Cycling and Formation of Larger Red Cells During Mouse and Human Erythropoiesis [preprint]

Erythroid terminal differentiation entails cell divisions that are coupled to progressive decreases in cell size. EpoR signaling is essential for the survival of erythroid precursors, but it is unclear whether it has other functions in these cells. Here we endowed mouse precursors that lack the EpoR with survival signaling, finding that this was sufficient to support their differentiation into enucleated red cells, but that the process was abnormal. Precursors underwent fewer and slower cell cycles and yet differentiated into smaller red cells. Surprisingly, EpoR further accelerated cycling of early erythroblasts, the fastest cycling cells in the bone marrow, while simultaneously increasing their cell size. EpoR-mediated formation of larger red cells was independent of the established pathway regulating red cell size by iron through Heme-regulated eIF2α kinase (HRI). We confirmed the effect of Epo on red cell size in human volunteers, whose mean corpuscular volume (MCV) increased following Epo administration. This increase persisted after Epo declined and was not the result of increased reticulocytes. Our work reveals a unique effect of EpoR signaling on the interaction between the cell cycle and cell growth. Further, it suggests new diagnostic interpretations for increased red cell volume, as reflecting high Epo and erythropoietic stress