Efficacy of liposomal dosage forms and hyperosmolar salines in experimental pharmacotherapy of acute lung injury

Hypertonic sodium chloride solutions and liposomal drugs with pulmotropic effect are of great interest for the treatment of acute lung injury (ALI). For the experiment, liposomes with dexamethasone, N-acetylcysteine (NAC), aprotinin and dye Cyanine-7 (Cy-7) were obtained. A liposome analysis was performed by means of spectrophotometry. ALI was modeled in rats by the administration of the damaging agents into the trachea. All the studied therapeutic agents increased the survival rate of the laboratory animals with ALI. The most effective experimental agent was liposomal dexamethason

О РОЛИ ГРИБОВ В ФОРМИРОВАНИИ ДОЗ ВНУТРЕННЕГО ОБЛУЧЕНИЯ НАСЕЛЕНИЯ, ПРОЖИВАЮЩЕГО НА РАДИОАКТИВНО ЗАГРЯЗНЕННЫХ ВСЛЕДСТВИЕ АВАРИИ НА ЧАЭС-ТЕРРИТОРИЯХ

The present overview describes the results of the 25-year studies devoted to the estimation of the contribution of radionuclide containing mushrooms to the internal exposure dose to the population affected by the Chernobyl NPP accident. A significant increase with the time after the accident is shown for the contribution of mushrooms to the population internal exposure dose. Factors are identified influencing variability in the estimations of radionuclide from the mushroom component contribution to the population internal exposure dose.В обзоре литературы дан анализ результатов 25-летних исследований, посвященных оценке вкла-да  грибов,  содержащих  радионуклиды,  в  формирование  доз  внутреннего  облучения  населения  вслед-ствие аварии на Чернобыльской АЭС. Показан достоверный рост во времени после аварии на ЧАЭС вклада грибов в дозу внутреннего облучения населения. Выделены факторы, влияющие на вариабель-ность оценок вклада радионуклидов от грибной компоненты в дозу внутреннего облучения населения

ON THE ROLE OF MUSHROOMS IN THE INTERNAL DOSE FORMATION TO THE POPULATION IN THE CHERNOBYL NPP ACCIDENT AFFECTED AREAS

The present overview describes the results of the 25-year studies devoted to the estimation of the contribution of radionuclide containing mushrooms to the internal exposure dose to the population affected by the Chernobyl NPP accident. A significant increase with the time after the accident is shown for the contribution of mushrooms to the population internal exposure dose. Factors are identified influencing variability in the estimations of radionuclide from the mushroom component contribution to the population internal exposure dose