ACTIVITY OF LYSOZYME IN THE BLOOD OF MONTH RATS AFTER ACUTE SOMATIC PAIN

Purpose: to study activity of lysozyme in the blood of month rats after acute somatic pain.Materials and methods: Experiments were conducted on white month non-linear rats. Acute somatic pain (4-5 levels of intensity) was simulated by electrocutaneous stimulation of the receptor zone of the root of the tail. The animals were decapitated and blood sampling was carried out to study the activity of lysozyme by nephelometric method after the acute somatic pain.Results: Lysozyme activity of intact month old rats which determined in the blood serum, is higher than in infants in the initial state.Summary: Lysozyme reaction to acute somatic pain in month old rats has a phase character: its activity increases, decreases and increases again

Analysis of survival after radical surgery for stomach cancer in odessa regional cancer center

The survival of patients with the locally advanced stage of stomach cancer (SC), who underwent various variants of preventive lymphatic nodes dissection, was considered. The survival of patients was compared with the stage and T, N indexes. Lymphadenectomy D2 were effective and increased cumulative survival in patient`s group T4aNoMo, stage IIB and T4aN1Mo, stage III A, and in groups of patients where D2 lymphadenectomy were ineffective - T4bNoMo, stage ІІІB, T4bN1Мo, stage ІІІB and T4aN2Мo, stage IIIB. D2 were more efficient operation in the case of tumor serosa invasion and invasion to the peritoneal cavity (SE) in the absence of multiple metastases to the regional lymph nodes (N1 according to the 7th revision of the classification - 1-2 metastatic lymph nodes), and when the tumor infiltrated the surrounding organs (SI) and the presence of multiple regional metastases, D2 lymphodissection did not gave positive results, comparising with D1

Department of pathological physiology

It is known that as long as antinociceptive system functions adequately pain can develop as a component of different injuries. One of the most important mechanisms of antinociception – humoral that means production of substances that block pain transmission and formation of pain feeling. Humoral mechanism includes: opioid, monoaminergic (norepinephrine, dopamine, serotonin), cholinergic, GABAergic, cannabinoid and orexin systems. Inflow of pain impulses induces production and excretion of different chemical substances which forms analgesia in different levels of pain system

FEATURES OF THE PATHOGENESIS OF VISCERAL PAIN

Peculiarities of visceral pain and its pathogenesis are analyzed in the article. The article presents role of receptor apparatus, which accepts algogenic information, conducting structures role of spinal cord and brain in the formation of visceral pain. The pain mediators, neurotransmitters of spinal cord, and the theory of referred pain are analyzed

CHANGE OF LYSOZYME’S LEVEL IN ACUTE SOMATIC PAIN IN ADULT RATS

Purpose. To study the effects of acute somatic pain on the activity of lysozyme in the blood of animals.Materials and methods. Experiments were conducted on white adult non-linear male rats. Acute somatic pain was simulated by electrocutaneous stimulation of the receptor zone of the root of the tail. The animals were decapitated and blood sampling was carried out to study the activity of lysozyme by nephelometric method after the acute somatic pain.Results. Quantity of lysozyme increased in 2 minutes and in 30 minutes after acute somatic pain. Level of lysozyme decreased to the baseline values in 60 minutes after painful stimulation. Statistically significant decline of its level was observed.Summary. Lysozyme gets involved in the algogenic process when acute pain is experienced. The reaction of lysozyme to the acute somatic pain is transient and biphasic: a rapid increase in the peripheral blood with subsequent decline below the initial values

Lymph node dissection impact on long-term survival rate of gastric cancer patients in Ukraine

Over a period of 2007-2011 188 stomach cancer (SC) patients have been included in the research in abdominal oncosurgical department of Odessa oncological center. Volume of lymph node dissections differed by quantity of lymph nodes to be removed. All patients were divided into three groups. Patients with D1 or D1+ lymph node dissections have been performed, totally 90 patients are included in group of historical control. In all cases so-called lymph node dissections for principal reasons have been executed. The multifactorial analysis of patients survival is implemented depending on a type of a lymph node dissections, a stage of the cancer, number of involved lymph nodes, involvement of the tumoral microcirculatory net (ly is carried out, v) signs of a perinevral invasion (Nev), availability of residual tumoral tissue (R), degree of a differentiation (G). Regardless of a disease stage, SC at 60 % of patients, represented with initially hematologicaly disseminated disease. 40 % of SC`s had no signs of intratumoral microcirculatory net involvement even in case of more than 15 regional lymph nodes are involved

The original formula for predicting the survival of gastric cancer patients undergoing surgical treatment

The purpose of this work was to find ways to predict the survival of gastric cancer patients. The study included 221 patients who were radically operated in the abdominal department of the Odessa Regional Oncology Center from 2007 to 2013. The life expectancy of this group of patients was measured in months. From the factors given in the article, only the age of the patient, the presence and invasion in neighboring organs and the number of organs resected during the operation were those factors that had a significant impact on the prognosis. A formula was obtained for the formal evaluation of the duration of patients. The results are preliminary. Conclusions. As a result of the regression analysis, a polynomial (formula) was obtained, which can be used to predict the survival of patients who underwent surgery for gastric cancer. There is a need to create clearer gradations of survival dependencies of cancer patients from different clinical and morphological situations. A mathematical apparatus with many variables can be used to create similar models for the analysis of survival in other types of pathology

ВИРУСНЫЙ ГЕПАТИТ А С РАЗВИТИЕМ АПЛАСТИЧЕСКОЙ АНЕМИИ У РЕБЕНКА 5 ЛЕТ (КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ)

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Застосування сучасних методів діагностики у практиці оральної хірургії

У даному виданні висвітлені досягнення сучасної медицини, а саме методів діагостики захворювань щелепно-лицевої ділянки. У навчальному посібнику представлені такі методи діагностики, як цитологічне та гістологічне дослідження, рентгенологічне дослідження, комп’ютерна та магніто -резонансна томаграфія, артроскопия, ультразвукове дослідження та дерматоскопія. Навчальний посібник містить ілюстровані зображення наведених методів обстеження; В данном издании освещены достижения современной медицины, а именно методов диагостикы заболеваний челюстно-лицевой области. В учебном пособии представлены такие методы диагностики, как цитологическое и гистологическое исследования, рентгенологическое исследование, компьютерная и магнитно -резонансная томаграфия, артроскопия, ультразвуковое исследование и дерматоскопия. Учебное пособие содержит иллюстрированные изображения приведенных методов обследования; This publication highlights the achievements of modern medicine, namely, the methods of diagostic diseases of the maxillofacial area. The training manual presents such diagnostic methods as cytological and histological research, X-ray examination, computer and magnetoresonance tomography, arthroscopy, ultrasound and dermatoscopy. The tutorial contains illustrated images of the following survey methods