Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases

A recent study described increased l‐lactate concentrations in ponies with gastrointestinal disease compared to horses, but blood glucose (BG) concentrations were not considered. The study tested the hypothesis that BG and l‐lactate concentrations are correlated in horses and ponies with gastrointestinal disease and that BG concentrations, not equid type (pony vs horse), are an independent predictor of L‐lactate concentrations. It was further hypothesized that equid type was an independent predictor of BG concentrations

Relativistic diffusion of elementary particles with spin

We obtain a generalization of the relativistic diffusion of Schay and Dudley for particles with spin. The diffusion equation is a classical version of an equation for the Wigner function of an elementary particle. The elementary particle is described by a unitary irreducible representation of the Poincare group realized in the Hilbert space of wave functions in the momentum space. The arbitrariness of the Wigner rotation appears as a gauge freedom of the diffusion equation. The spin is described as a connection of a fiber bundle over the momentum hyperbolic space (the mass-shell). Motion in an electromagnetic field, transport equations and equilibrium states are discussed.Comment: 21 pages,minor changes,the version published in Journ.Phys.

Association between hyponatremia and neurological dysfunction in hospitalized foals

Hyponatremia and rapid correction of hyponatremia can lead to neurological abnormalities. The objective of the study was to determine whether plasma sodium concentrations (Na+) and speed of correction of hyponatremia are significantly associated with neurological abnormalities in foals

Brownian motion in AdS/CFT

We study Brownian motion and the associated Langevin equation in AdS/CFT. The Brownian particle is realized in the bulk spacetime as a probe fundamental string in an asymptotically AdS black hole background, stretching between the AdS boundary and the horizon. The modes on the string are excited by the thermal black hole environment and consequently the string endpoint at the boundary undergoes an erratic motion, which is identified with an external quark in the boundary CFT exhibiting Brownian motion. Semiclassically, the modes on the string are thermally excited due to Hawking radiation, which translates into the random force appearing in the boundary Langevin equation, while the friction in the Langevin equation corresponds to the excitation on the string being absorbed by the black hole. We give a bulk proof of the fluctuation-dissipation theorem relating the random force and friction. This work can be regarded as a step toward understanding the quantum microphysics underlying the fluid-gravity correspondence. We also initiate a study of the properties of the effective membrane or stretched horizon picture of black holes using our bulk description of Brownian motion.Comment: 54 pages (38 pages + 5 appendices), 5 figures. v2: references added, clarifications in 6.2. v3: clarifications, version submitted to JHE

BRIM-P: A phase I, open-label, multicenter, dose-escalation study of vemurafenib in pediatric patients with surgically incurable, BRAF mutation-positive melanoma.

BACKGROUND: Vemurafenib, a selective inhibitor of BRAF kinase, is approved for the treatment of adult stage IIIc/IV BRAF V600 mutation-positive melanoma. We conducted a phase I, open-label, dose-escalation study in pediatric patients aged 12-17 years with this tumor type (NCT01519323). PROCEDURE: Patients received vemurafenib orally until disease progression. Dose escalation was conducted using a 3 + 3 design. Patients were monitored for dose-limiting toxicities (DLTs) during the first 28 days of treatment to determine the maximum tolerated dose (MTD). Safety/tolerability, tumor response, and pharmacokinetics were evaluated. RESULTS: Six patients were enrolled (720 mg twice daily [BID], n = 3; 960 mg BID [n = 3]). The study was terminated prematurely due to low enrollment. No DLTs were observed; thus, the MTD could not be determined. All patients experienced at least one adverse event (AE); the most common were diarrhea, headache, photosensitivity, rash, nausea, and fatigue. Three patients experienced serious AEs, one patient developed secondary cutaneous malignancies, and five patients died following disease progression. Mean steady-state plasma concentrations of vemurafenib following 720 mg and 960 mg BID dosing were similar or higher, respectively, than in adults. There were no objective responses. Median progression-free survival and overall survival were 4.4 months (95% confidence interval [CI] = 2.7-5.2) and 8.1 months (95% CI = 5.1-12.0), respectively. CONCLUSIONS: A recommended and effective dose of vemurafenib for patients aged 12-17 years with metastatic or unresectable melanoma was not identified. Extremely low enrollment in this trial highlights the importance of considering the inclusion of adolescents with adult cancers in adult trials

Deformed Algebras from Inverse Schwinger Method

We consider a problem which may be viewed as an inverse one to the Schwinger realization of Lie algebra, and suggest a procedure of deforming the so-obtained algebra. We illustrate the method through a few simple examples extending Schwinger's $su(1,1)$ construction. As results, various q-deformed algebras are (re-)produced as well as their undeformed counterparts. Some extensions of the method are pointed out briefly.Comment: 14 pages, Jeonju University Report, Late