The Elliptical Galaxy formerly known as the Local Group: Merging the Globular Cluster Systems

Prompted by a new catalogue of M31 globular clusters, we have collected together individual metallicity values for globular clusters in the Local Group. Although we briefly describe the globular cluster systems of the individual Local Group galaxies, the main thrust of our paper is to examine the collective properties. In this way we are simulating the dissipationless merger of the Local Group, into presumably an elliptical galaxy. Such a merger is dominated by the Milky Way and M31, which appear to be fairly typical examples of globular cluster systems of spiral galaxies. The Local Group `Elliptical' has about 700 +/- 125 globular clusters, with a luminosity function resembling the `universal' one. The metallicity distribution has peaks at [Fe/H] ~ -1.55 and -0.64 with a metal-poor to metal-rich ratio of 2.5:1. The specific frequency of the Local Group Elliptical is initially about 1 but rises to about 3, when the young stellar populations fade and the galaxy resembles an old elliptical. The metallicity distribution and stellar population corrected specific frequency are similar to that of some known early type galaxies. Based on our results, we briefly speculate on the origin of globular cluster systems in galaxies.Comment: 22 pages, Latex, 4 figures, 5 tables, submitted to A &

National quality and performance system for Divisions of General Practice: early reflections on a system under development

Governments are increasingly introducing performance management systems to improve the quality and outcomes of health care. Two types of approaches have been described: assurance systems that use summative information for external accountability and internally driven systems that use formative information for continuous quality improvement. Australia recently introduced a National Quality and Performance System (NQPS) for Divisions of General Practice that has the dual purposes of increasing accountability and improving performance. In this article, we ask whether the framework can deliver on its objectives for achieving accountability and fostering performance improvement. We examine the system in terms of four factors identified in a recent systematic review of indicator systems known to improve their use. These are: involving stakeholders in development; having clear objectives; approach to data collection and analysis including using 'soft data' to aid interpretation; and feeding back information. RESULTS: We found that early consultative processes influenced system development. The system promotes the collection of performance information against defined program objectives. Data includes a mix of qualitative and quantitative indicators that are fitted to a conceptual framework that facilitates an approach to performance assessment that could underpin continuous quality improvement at the Division level. Feedback of information to support the development of quality improvement activities has not been fully developed. CONCLUSION: The system currently has elements that, with further development, could support a more continuous quality improvement or assurance based approach. Careful consideration needs to be given to the development of methods for analysis and review of performance indicators, performance assessment and engagement with consumers. The partnership arrangement that supported early development could be expected to serve as an important vehicle for further development

Improving Health and Well-Being: Connecting Research and Practice. The 24th Annual Conference of the Health Care Systems Research Network

The 24th annual conference of the Health Care Systems Research Network (HCSRN, formerly the HMO Research Network), held April 11–13, 2018, in Minneapolis, Minnesota, attracted 357 attendees. The HCSRN is a consortium of 18 community-based research organizations embedded in or affiliated with large health care delivery systems. Its annual research conference, held since 1994, is a unique venue that brings diverse stakeholders (eg, research teams, clinicians, patients, funders) together to explore a range of health research topics and scientific findings, with a unifying goal of connecting applied research to real-world care delivery for the betterment of individual and community health. The 2018 conference was hosted by Minneapolis-based HealthPartners Institute and organized around 3 tracks: Research & Results, Practical Application, and Data Science & Informatics. Themes of the 4 plenary, 7 panel, 36 oral abstract, and 111 poster presentations included the learning health system, the opioid epidemic, health disparities, high costs of care, informing population health policy with evidence, and how to use storytelling to present data to inspire change, among others

The Grizzly, March 19, 1982

New Room Selection Procedure Instituted • Thefts and Break-ins Challenge Campus Security • Board Activates New Program • Going to the Dogs? • USGA Notes • News Briefs: Special Olympics Returns: Hugger Needed!; Red Cross Bloodmobile Urges Volunteer Donors; Advertising Association Sponsors Career Conference • Newly Formed Astronomy Club Approved by SAC • Bach Birthday Concert • UC Track and Field: A Team to be Reckoned With • Blades Shred F&M • Lacrosse Looking for Improvement • Potsdam Frustrates UC Again • Women\u27s Basketball Takes Second in Cinderella MACs • Aqua Women Achieve Personal Best at MACs and Nationalshttps://digitalcommons.ursinus.edu/grizzlynews/1075/thumbnail.jp

Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice

Targeted sequencing, manual genome annotation, phylogenetic analysis and mass spectrometry were used to characterise major urinary proteins (MUPs) and the Mup clusters of two strains of inbred mice

Modelling the impact of the AN-ACC in Australia.The Resource Utilisation and Classification Study: Report 4

A national study to develop a new methodology for determining appropriate funding for places in residential aged care homes, the ‘Resource Utilisation and Classification Study’ (RUCS), was commissioned by the Commonwealth Department of Health (the Department) in August 2017 and undertaken by the Australian Health Services Research Institute (AHSRI) at the University of Wollongong. This report is the fourth in a series, written to present the results of this important national study. Each report deals with a different aspect of the project, as described in Appendix 1. In this report, Report 4, the findings from Study Three of the RUCS are presented. The purpose of the casemix profiling study covered in this report was to develop a national casemix profile of residents in residential aged care facilities in Australia, to identify any differences in resident casemix by facility type (i.e. by location, ownership type and size), and to model and test the likely financial impact of implementing the blended payment model nationally. To do so, a nationally representative sample was used to model patterns of resident need and to investigate the funding implications of a new payment model based on resident casemix

Recent advances in antibiotic resistance diagnosis using SERS : focus on the "big 5" challenges

Antibiotic resistant bacteria constitute a global health threat. It is essential for healthcare professionals to prescribe the correct dose of an effective antibiotic to mitigate the bacterial infection in a timely manner to improve the therapeutic outcomes to the patient and prevent the dissemination of antibiotic resistance. To achieve this, there is a need to implement a rapid and ultra-sensitive clinical diagnosis to identify resistant bacterial strains and monitor the effect of antibiotics. In this review, we highlight the use of surface enhanced Raman scattering (SERS) as a powerful diagnostic technique for bacterial detection and evaluation. Initially, this is viewed through a lens covering why SERS can surpass other traditional techniques for bacterial diagnosis. This is followed by different SERS substrates design, detection strategies that have been used for various bacterial biomarkers, how SERS can be combined with other diagnostic platforms to improve its performance towards the bacterial detection and the application of SERS for antibiotic resistance diagnosis. Finally, the recent progress in SERS detection methods in the last decade for the "Big 5" antibiotic resistant challenges as demonstrators of public health major threats is reviewed, namely: Methicillin-resistant Staphylococcus aureus (MRSA), Carbapenem-resistant Enterobacteriaceae (CRE) / Extended-spectrum beta-lactamases (ESBLs), Mycobacterium tuberculosis (TB), Vancomycin-resistant Enterococcus (VRE) and Neisseria Gonorrhoea (NG). This review provides a comprehensive view of the current state of the art with regard to using SERS for assessing antibiotic resistance with a future outlook on where the field go head in the coming years

Thermoresponsive polymer micropatterns fabricated by dip-pen nanolithography for a highly controllable substrate with potential cellular applications

We report a novel approach for patterning thermoresponsive hydrogels based on N,N-diethylacrylamide (DEAAm) and bifunctional Jeffamine ED-600 by dip-pen nanolithography (DPN). The direct writing of micron-sized thermoresponsive polymer spots was achieved with efficient control over feature size. A Jeffamine-based ink prepared through the combination of organic polymers, such as DEAAm, in an inorganic silica network was used to print thermosensitive arrays on a thiol-silanised silicon oxide substrate. The use of a Jeffamine hydrogel, acting as a carrier matrix, allowed a reduction in the evaporation of ink molecules with high volatility, such as DEAAm, and facilitated the transfer of ink from tip to substrate. The thermoresponsive behaviour of polymer arrays which swell/de-swell in aqueous solution in response to a change in temperature was successfully characterised by atomic force microscopy (AFM) and Raman spectroscopy: a thermally-induced change in height and hydration state was observed, respectively. Finally, we demonstrate that cells can adhere to and interact with these dynamic features and exhibit a change in behaviour when cultured on the substrates above and below the transition temperature of the Jeffamine/DEAAm thermoresponsive hydrogels. This demonstrates the potential of these micropatterned hydrogels to act as a controllable surface for cell growth

The Grizzly, April 2, 1982

PA Special Olympics This Weekend • Room Selection Continues • Student Publications Staffs Chosen • Parents Day Plans Offer Variety of Talents • USGA Notes • Letters to the Editor • Dean of College Accepting Nominations for Lindback Award • Class Elections Next Week • News Briefs: Hooters Concert Tickets Now Available; Friends of Library Book Sale; Senior Women Invited to Parents Day Reception; Photography in Space Topic of Final Forum; Scholarship Offered for Students of Hellenic Descent • Food Day: A Chance to Share the Wealth • New Library Survey Conducted • Alumna Presents DuPont Grant • Students Direct Comedy Series • Duet Takes First in Talent Show • F&M Tops Track Team • W\u27s Tennis Drops Warm-up • Division 1 West Chester a Little Too Strong • MAC Champs Back • Harvard Slips by Lady Bears • Batsmen Split Twin Bill • Softball Team Takes Two Out of Threehttps://digitalcommons.ursinus.edu/grizzlynews/1077/thumbnail.jp