Accretion-powered Millisecond Pulsar Outbursts

The population of accretion-powered millisecond pulsars has grown rapidly over the last four years, with the discovery of six new examples to bring the total sample to seven. While the first six discovered are transients active for a few weeks every two or more years, the most recently-discovered source HETE J1900.1-2455, has been active for more than 8 months. We summarise the transient behaviour of the population to estimate long-term time-averaged fluxes, and equate these fluxes to the expected mass transfer rate driven by gravitational radiation in order to constrain the distances. We also estimate an upper limit of 6 kpc to the distance of IGR J00291+5934 based on the non-detection of bursts from this source.Comment: 5 pages, 2 figures, to be published in: "The Transient Milky Way: a perspective for MIRAX", eds. F. D'Amico, J. Braga & R. Rothschild, AIP Conf. Pro

Likelihood-based inference of B-cell clonal families

The human immune system depends on a highly diverse collection of antibody-making B cells. B cell receptor sequence diversity is generated by a random recombination process called "rearrangement" forming progenitor B cells, then a Darwinian process of lineage diversification and selection called "affinity maturation." The resulting receptors can be sequenced in high throughput for research and diagnostics. Such a collection of sequences contains a mixture of various lineages, each of which may be quite numerous, or may consist of only a single member. As a step to understanding the process and result of this diversification, one may wish to reconstruct lineage membership, i.e. to cluster sampled sequences according to which came from the same rearrangement events. We call this clustering problem "clonal family inference." In this paper we describe and validate a likelihood-based framework for clonal family inference based on a multi-hidden Markov Model (multi-HMM) framework for B cell receptor sequences. We describe an agglomerative algorithm to find a maximum likelihood clustering, two approximate algorithms with various trade-offs of speed versus accuracy, and a third, fast algorithm for finding specific lineages. We show that under simulation these algorithms greatly improve upon existing clonal family inference methods, and that they also give significantly different clusters than previous methods when applied to two real data sets

Dynamics of Output and Employment in the U.S. Economy

This paper investigates the changing relationship between employment and real output in the U.S. economy from 1948 to 2010 both at the aggregate level and at some major industry-grouping levels of disaggregation. Real output is conventionally measured as value added corrected for price inflation, but there are some industries in which no independent measure of value added is possible and existing statistics depend on imputing value added to equal income. Indexes of output that exclude these imputations are closely correlated with employment over the whole period, and remain more closely correlated during the current business cycle. This analysis offers insights into deeper structural changes that have taken place in the U.S. economy over the past few decades in a context marked by the following three factors: (i) the service (especially the financial) sector has grown in importance, (ii) the economy has become more globalized, and (iii) the policy orientation has increasingly become neoliberal. We demonstrate an economically significant reduction in the coefficient relating employment growth to output growth over the business cycles since 1985. Some of this change is due to sectoral shifts toward services, but an important part of it reflects a reduction in the coefficient for the goods and material value-adding sectors.Okun's Law; Kaldor-Verdoorn Eect; Global restructuring; measurement of real output

Hubble Space Telescope: Goddard high resolution spectrograph instrument handbook. Version 2.1

The Goddard High Resolution Spectrograph (GHRS) is an ultraviolet spectrometer which has been designed to exploit the imaging and pointing capabilities of the Hubble Space Telescope. It will obtain observations of astronomical sources with greater spectral, spatial and temporal resolution than has been possible with previous space-based instruments. Data from the GHRS will be applicable to many types of scientific investigations, including studies of the interstellar medium, stellar winds, chromospheres and coronae, the byproducts and endproducts of stellar evolution, planetary atmospheres, comets, and many kinds of extragalactic sources. This handbook is intended to introduce the GHRS to potential users. The main purpose is to provide enough information to explore the feasibility of possible research projects and to plan, propose and execute a set of observations. An overview of the instrument performance, which should allow one to evaluate the suitability of the GHRS to specific projects, and a somewhat more detailed description of the GHRS hardware are given. How observing programs will be carried out, the various operating modes of the instrument, and the specific information about the performance of the instrument needed to plan an observation are discussed