3 research outputs found
Activating and inhibitory functions of WNT/β-catenin in the induction of cytochromes P450 by nuclear receptors in HepaRG cells
Get PDFA Natural Variant of the Heme-Binding Signature (R441C) Resulting in Complete Loss of Function of CYP2D6 DMD#15149 2 running title: A Novel Heme-Signature Mutation in CYP2D6
No full textA natural CYP2B6 TATA box polymorphism (-82T→C) leading to enhanced transcription and relocation of the transcriptional start site,”
No full textNumber of references: 40 Number of words in the Abstract .7 pmol/mg*min, p=0.042, respectively). This promoter polymorphism thus contributes to CYP2B6 functional variability and represents a novel mechanism by which mutations can enhance transcription. Furthermore, a detailed inter-species comparison of CYP2B promoters and transcription start sites provided novel insights into evolutionary relationships
