Periodontal Implications of Hepatitis C Infection

Periodontal tissues exhibit important vascular, lymphatic, and nervous connections with the rest of the body. Thus, periodontal inflammation caused by the interaction between the subgingival bacterial biofilm and the host immune response has an impact reaching further than the oral cavity. The concept of “periodontal medicine” reunites the bidirectional relationships that exist between periodontal disease and systemic conditions such as diabetes mellitus or cardiovascular disease. The chronic inflammation of hepatic tissues during hepatitis C virus (HCV) infection causes changes in the general homeostasis that can reverberate at periodontal level and influence periodontal inflammation. Various mechanisms such as insulin resistance or pro-inflammatory cytokines production could be the link between the two conditions. In addition, periodontal inflammation could impact HCV transmission, as HCV RNA molecules and antibodies have been found in infected patients’ saliva and gingival fluid. During periodontal inflammation, gingival bleeding is frequent, and the viral molecules could enter oral fluids while being carried by peripheral blood cells. Clinical particularities that suggest the onset of periodontal disease have also been frequently observed in HCV-infected patients. The connections between periodontal disease and hepatitis C need to take into consideration by practitioners of both specialties due to their important implications on clinical manifestations and treatment strategies

Periodontal status and inflammatory markers in gingival crevicular fluid of patients with periodontitis and colorectal cancer

Objectives. The present pilot study was carried out to evaluate the periodontal status, the levels of interleukin-6 and tumor necrosis factor alpha in gingival crevicular fluid on hospitalized patients with colorectal cancer. Materials and Methods. The sample of our study was represented by 74 patients with colorectal cancer. They were assigned to one of the two study groups, based on cancer’s stages, as follows: (i) stage III-IV: 51 patients (A-group); (ii) stage I-II: 23 patients (B-group). For each participant periodontal parameters were recorded and gingival crevicular fluid samples were collected and immunologically assessed. Results. Statistically significant differences were found between the two groups, regarding probing pocket depth, clinical attachment loss, bleeding on probing, interleukin-6 and tumor necrosis factor alpha. In A-group, statistically significant correlations were found between the inflammatory markers and probing pocket depth and between their levels and bleeding on probing. In B-group, statistically significant correlation was found between the levels of interleukin-6 and bleeding on probing. Conclusions. Our results suggest an association between the severity of periodontitis, the studied immunologic inflammatory markers and colorectal cancer’s severity

Immunological Insights on Pathogenic Connections between Hepato-Digestive Disorders and Periodontal Conditions

The oral cavity is an integral part of the digestive tract and thus significant diseases, including periodontitis, can have an important impact on the normal nutritional functions of the body. Certain diseases of the hepato-digestive system have an inflammatory component, such as chronic hepatitis, fatty liver disease, or gastric cancer. This inflammatory reaction is mainly driven by pro-inflammatory chemokines. This is also the case for periodontitis, a condition characterized by the inflammation of the supporting tissues of teeth. Thus, significant pathogenic connections mediated by pro-inflammatory chemokines could exist between periodontitis and diseases of the hepato-digestive system

Cytokines’ Involvement in Periodontal Changes

The bacterial challenge on the periodontal tissues triggers an inflammatory reaction, driven by pro-inflammatory cytokines, that eventually leads to the periodontal structures’ damage. The pathogenic mechanisms of this inflammatory reaction are complex and are influenced by the type of host-immune response and certain local and systemic factors. These factors can influence periodontal inflammation, through the action of the various pro-inflammatory cytokines. Periodontal disease and certain systemic conditions can have a mutual association, as the pathogenic mechanisms of these diseases can involve similar molecular and cellular elements. The concept of ‘periodontal medicine’ comprises these pathogenic connections, focusing on the key role that periodontal health has on the general homeostasis and well-being

Şantierul arheologic Tîrgşor (r. şi reg. Ploeşti) / Le chantier archéologique de Tîrgşor

Popescu Dorin, Constantinescu Nicolae, Diaconu Gheorghe, Morintz Sebastian. Şantierul arheologic Tîrgşor (r. şi reg. Ploeşti) / Le chantier archéologique de Tîrgşor. In: Materiale şi cercetări arheologice, N°6 1959. pp. 727-745

STUDIES ON THE EVOLUTION OF APPLE FRUITS QUALITY DURING THE PRESERVATION PERIOD IN COLD STORAGE FACILITIES

The apple fruits harvest maturity is very brief and does not coincide with the consumption maturity. The process of ripening continues after fruit harvesting, and the consumption maturity is achieved earlier or later in the storage period. Present paper highlights the evolution of some apples characteristics (penetration resistance, chlorophyll fluorescence), in the storage period,the characteristics that define the quality fruits consumption. The study was carried out at the Research Institute for Fruit Growing Pitesti-Maracineni where the fruits of two apples varieties ('Dalinred', and 'Goldrush') that have been harvested in October and stored in cold storage. After four months of storage (January) and after five months of storage (February), determinations of penetration resistance and chlorophyll fluorescence were carried out. The results obtained have shown that penetration resistance of the 'Goldrush' fruits variety in January had higher values than penetration resistance of the 'Dalinred' fruits variety and the values of resistance decrease with increasing storage period. Regarding chlorophyll fluorescence, the values have the same tendency as well as those of penetration resistance, a small decreasing of values, with the increasing storage period. Both, the penetration resistance values as well as the chlorophyll fluorescence values, proved a good duration for maintaining fruit quality, and the decreasing values in the two periods of determination (January and February), was insignificant

Perception of the importance of oral hygiene in a group of adults from South-West Romania

Oral hygiene is a dental procedure with the role of removing bacterial plaque and action to prevent oral diseases, including periodontal disease. Oral prophylaxis includes both daily dental hygiene (daily brushing, flossing and mouthwash) and the visits to the dentist for professional hygiene and prophylaxis. The correct brushing of the teeth is important not only for maintaining oral health but also for the health of the whole body, because there are correlations between diseases of the oral cavity and problems of the digestive tract or even heart disease

Study of health and safety in the manufacturing industry using Pareto analysis

The present paper carries out a study on health and safety in the manufacturing industry. The health and safety is analyzed for industrial workers in Brasov county for the years 2017 and 2018. The analysis is based on data for work related accidents and the processing was made using the Pareto Analysis. By complying with the 80/20 rule, it can be focused on the analysis of the 20% of the causes of work accidents that account for 80% of the total work accidents analyzed. Finally, it is presented which actions that can be taken to reduce accidents based on the analysis of the specific stages. After applying the Pareto Analysis in the year 2018 are obtained satisfactory results compared to the year 2017, thus optimizing the performance of the industrial activity in terms of health and safety and improve Quality Assurance in Industrial Manufacturing

Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives

Periodontitis is characterized by low-grade inflammation of the periodontal tissues, the structures that support and connect the teeth to the maxilla and mandible. This inflammation is caused by the accumulation of subgingival bacterial biofilm and gradually leads to the extensive damage of these tissues and the consequent loss of teeth. Hepatitis B is a major global health concern; infection with the hepatitis B virus causes significant inflammation of the liver and the possibility of its gradual evolution to cirrhosis. Hepatitis D, caused by infection with the delta hepatitis virus, is manifest only in patients already infected with the type B virus in a simultaneous (co-infected) or superimposed (superinfected) manner. The dental and periodontal status of patients with hepatitis B/D could exhibit significant changes, increasing the risk of periodontitis onset. Moreover, the progression of liver changes in these patients could be linked to periodontitis; therefore, motivating good oral and periodontal health could result in the prevention and limitation of pathological effects. Given that both types of diseases have a significant inflammatory component, common pro-inflammatory mediators could drive and augment the local inflammation at both a periodontal and hepatic level. This suggests that integrated management of these patients should be proposed, as therapeutical means could deliver an improvement to both periodontal and hepatic statuses. The aim of this review is to gather existing information on the proposed subject and to organize significant data in order to improve scientific accuracy and comprehension on this topic while generating future perspectives for research

Periodontitis, Metabolic and Gastrointestinal Tract Diseases: Current Perspectives on Possible Pathogenic Connections

Comprehensive research conducted over the past decades has shown that there is a definite connection between periodontal and systemic conditions, leading to the development and consolidation of the “periodontal medicine” concept. The 2018 classification of periodontal conditions uses this concept as a key element of the precise diagnosis of and individualized therapeutical protocols for periodontitis patients. The topic of this review is the pathogenic connections that exist between periodontal disease and metabolic/digestive tract conditions. It is important to remember that the oral cavity is a key element of the digestive tract and that any conditions affecting its integrity and function (such as periodontitis or oral cancer) can have a significant impact on the metabolic and gastrointestinal status of a patient. Thus, significant diseases with links to metabolic or digestive disruptions were chosen for inclusion in the review, such as diabetes mellitus, hepatic conditions and gastric cancers. Periodontal pathogenic mechanisms share several significant elements with these conditions, including mutual pro-inflammatory mediators, bacterial elements and genetic predisposition. Consequently, periodontal screening should be recommended for affected patients, and conversely, periodontitis patients should be considered for careful monitoring of their metabolic and digestive status