The poetry of Tristan Corbiere with particular reference to influences, prosody and style

In Chapter I of this thesis, I have indicated the principal influences on Corbiere's poetry. Firstly, I have shown that the non-literary influences are of primary importance and inspired the majority of Corbiere's poems. Of these, Brittany is of outstanding significance, being the first and most permanent of all the influences: it has inspired two complete sections of his work. Next, in Chapter II, I have dealt with the literary influences showing that, in spite of Corbiere's claims of independance, both Romantic poetry and Parnassian poetry are clearly reflected in Les Amours Jaunes. Indeed, references are made to all the major poets of his century. In Chapter III, on prosody, I have analysed the various forms used by Corbiere, indicating where he was following tradition, where he was simply breaking the rules in a search for greater freedom, and where he was experimenting with new forms. In Chapter IV, I have shown that certain aspects of Corbiere's style are original, such as his use of imagery, his vocabulary, the oral quality of his poetry, and his use of punctuation. He experimented in his use of language in order to attain novel effects. Irony has permeated all aspects of Corbiere's work. Finally, in Chapter V, I have outlined the influence of Corbiere on later poets. Much of his work seems akin to that of the Symbolists and Decadents. Either this is merely coincidence, due to the fact that Corbiere and these writers followed current literary trends, or it may be that Vorbiere has actually influenced the later work of the Symbolists and Decadents. Corbiere's influence can be seen most clearly in the work of the "Fantaisistes": Francis Carco, P.-J. Toulet, Tristan Dereme and Andre Salmon. More interesting, perhaps, is Corbiere's influence abroad: both Ezra Pound and T.S. Eliot drew inspiration from Les Amours jaunes.<p

Impact of teacher’s method, attitude and motivation in teaching and learning of literature in English

This is a survey carried out to ascertain the extent to which teaching method, teachers’ and student’s attitude as well as their motivation affect teaching and learning of Literature in English and hence students’ academic performance in the subject. Data for the research was obtained by means of structured questionnaire administered on one hundred and twenty respondents randomly drawn from ten secondary schools in Ogba/Egbema/Ndoni local government area of Rivers State ONELGA. Data obtained was computed into frequency and analyzed by statistical mean. Results of data analysis showed that mean values for all items raised in the questionnaire were above 2.5 and hence accepted as being significant for the factor under consideration. It was therefore concluded that lack of adequate qualified teachers, negative and unfriendly attitude of teachers to the teaching profession and students as well as poor teaching methods and motivation were identified as problems of teaching Literature in- English in secondary schools to a large extent in ONELGA. From the foregoing, it was recommended that among others, Government should motivate teachers to enroll for further training; instructional materials should be provided for the teachers and students. Also, teachers should develop good cordial relationship with their students to enhance teaching and learning well as adopt the best teaching method that will meet the students’ needs

Distributional Limits of Bats in Alaska

Bats in temperate regions are relatively well studied, yet little research has focused on the northern limit of their distribution. We document the northwestern extent of bats in North America using museum holdings, literature records, and field research in Alaska. Six bat species are confirmed from Alaska: Myotis lucifugus, M. keenii, M. californicus, M. volans, Lasionycteris noctivagans, and Eptesicus fuscus. M. lucifugus occurs throughout much of Alaska south of the Arctic Circle, whereas four other species occur only in Southeast Alaska. Climate, roost availability, extent of forested habitat, geographic barriers, length of night, and prey abundance appear to influence the distribution of bats in Alaska, although the relative contribution of these factors is unknown.Si, dans les régions tempérées, les chauves-souris ont fait l'objet d'études relativement approfondies, on a par contre mené peu de recherches sur la limite septentrionale de leur répartition. Cet article décrit l'extension nord-ouest de l'aire des chauves-souris en Amérique du Nord en faisant appel à des pièces muséologiques, des documents comportant des relevés, et des recherches sur le terrain en Alaska. On confirme que six espèces de chauves-souris se retrouvent en Alaska: Myotis lucifugus, M. keenii, M. californicus, M. volans, Lasionycteris noctivagans et Eptesicus fuscus. M. lucifugus est répandue presque partout en Alaska au sud du cercle polaire, tandis que quatre autres espèces ne se retrouvent que dans le sud-est de l'Alaska. Il semble que le climat, la disponibilité des sites de reproduction, l'étendue de l'habitat forestier, les barrières géographiques, la longueur de la nuit et l'abondance des proies influencent la distribution des chauves-souris en Alaska, bien qu'on ne connaisse pas la contribution relative de ces facteurs

Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the Endoplasmic Reticulum Stress Response

We report the first observation that endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) can decrease when a central nervous system drug acts as an intracellular pharmacological chaperone for its classic receptor. Transient expression of α4β2 nicotinic receptors (nAChRs) in Neuro-2a cells induced the nuclear translocation of activating transcription factor 6 (ATF6), which is part of the UPR. Cells were exposed for 48 h to the full agonist nicotine, the partial agonist cytisine, or the competitive antagonist dihydro-β-erythroidine; we also tested mutant nAChRs that readily exit the ER. Each of these four manipulations increased Sec24D-enhanced green fluorescent protein fluorescence of condensed ER exit sites and attenuated translocation of ATF6-enhanced green fluorescent protein to the nucleus. However, we found no correlation among the manipulations regarding other tested parameters [i.e., changes in nAChR stoichiometry (α4_2β2_3 versus α4_3β2_2), changes in ER and trans-Golgi structures, or the degree of nAChR up-regulation at the plasma membrane]. The four manipulations activated 0 to 0.4% of nAChRs, which shows that activation of the nAChR channel did not underlie the reduced ER stress. Nicotine also attenuated endogenously expressed ATF6 translocation and phosphorylation of eukaryotic initiation factor 2α in mouse cortical neurons transfected with α4β2 nAChRs. We conclude that, when nicotine accelerates ER export of α4β2 nAChRs, this suppresses ER stress and the UPR. Suppression of a sustained UPR may explain the apparent neuroprotective effect that causes the inverse correlation between a person's history of tobacco use and susceptibility to developing Parkinson's disease. This suggests a novel mechanism for neuroprotection by nicotine

Pathway Analysis of Differentially Expressed Genes in Patients with Acute Aortic Dissection

Background: Acute aortic dissection (AAD) is a life-threatening condition with high mortality and a relatively unclarified pathophysiological mechanism. Although differentially expressed genes in AAD have been recognized, interactions between these genes remain poorly defined. This study was conducted to gain a better understanding of the molecular mechanisms underlying AAD and to support the future development of a clinical test for monitoring patients at high risk. Materials and Methods: Aortic tissue was collected from 19 patients with AAD (mean age 61.7 ± 13.1 years), and from eight other patients (mean age 32.9 ± 12.2 years) who carried the mutated gene for Marfan syndrome (MS). Six patients (mean age 56.7 ± 12.3 years) served as the control group. The PIQOR TM Immunology microarray with 1076 probes in quadruplicates was utilized; the differentially expressed genes were analysed in a MedScan search using PathwayAssist software. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and protein analysis were performed. Results: Interactions of MS fibrillin-1 (FBN1) in the MedScan pathway analysis showed four genes, fi bulin-1 (FBLN1), fi bulin-2 (FBLN2), decorin (DCN) and microfi brillar associated protein 5 (MFAP5), which were differentially expressed in all tissue from AAD. The validation of these genes by qRT-PCR revealed a minimum of three-fold downregulation of FBLN1 (0.5 ± 0.4 vs. 6.1 ± 2.3 fold, p = 0.003) and of DCN (2.5 ± 1.0 vs. 8.5 ± 4.7 fold, p = 0.04) in AAD compared to MS and control samples. Conclusions: Downregulation of fibrillin-1 (FBN1) may weaken extracellular components in the aorta and/or interfer with the transmission of cellular signals and eventually cause AAD. Additional research on these four identified genes can be a starting point to develop a diagnostic tool

High-Resolution Microendoscopy for the Detection of Cervical Neoplasia in Low-Resource Settings

Cervical cancer is the second leading cause of cancer death among women in developing countries. Developing countries often lack infrastructure, cytotechnologists, and pathologists necessary to implement current screening tools. Due to their low cost and ease of interpretation at the point-of-care, optical imaging technologies may serve as an appropriate solution for cervical cancer screening in low resource settings. We have developed a high-resolution optical imaging system, the High Resolution Microendoscope (HRME), which can be used to interrogate clinically suspicious areas with subcellular spatial resolution, revealing changes in nuclear to cytoplasmic area ratio. In this pilot study carried out at the women's clinic of Princess Marina Hospital in Botswana, 52 unique sites were imaged in 26 patients, and the results were compared to histopathology as a reference standard. Quantitative high resolution imaging achieved a sensitivity and specificity of 86% and 87%, respectively, in differentiating neoplastic (≥CIN 2) tissue from non-neoplastic tissue. These results suggest the potential promise of HRME to assist in the detection of cervical neoplasia in low-resource settings

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK). However, the molecular details of how metformin controls T cell immune responses have not been studied nor is there any direct evidence that metformin acts on T cells via AMPK. Here, we report that metformin regulates cell growth and proliferation of antigen-activated T cells by modulating the metabolic reprogramming that is required for effector T cell differentiation. Metformin thus inhibits the mammalian target of rapamycin complex I signalling pathway and prevents the expression of the transcription factors c-Myc and hypoxia-inducible factor 1 alpha. However, the inhibitory effects of metformin on T cells did not depend on the expression of AMPK in T cells. Accordingly, experiments with metformin inform about the importance of metabolic reprogramming for T cell immune responses but do not inform about the importance of AMPK

National Non-Communicable Diseases Conferences- A Platform to Inform Policies and Practices in Tanzania

Background: Non-communicable diseases (NCDs) arise from diverse risk factors with differences in the contexts and variabilities in regions and countries. Addressing such a complex challenge requires local evidence. Tanzania has been convening stakeholders every year to disseminate and discuss scientific evidence, policies, and implementation gaps, to inform policy makers in NCDs responses. This paper documents these dissemination efforts and how they have influenced NCDs response and landscape in Tanzania and the region. Methods: Desk review was conducted through available MOH and conference organizers’ documents. It had both quantitative and qualitative data. The review included reports of the four NCDs conferences, conference organization, and conduct processes. In addition, themes of the conferences, submitted abstracts, and presentations were reviewed. Narrative synthesis was conducted to address the objectives. Recommendations emanated from the conference and policy uptake were reviewed and discussed to determine the impact of the dissemination. Findings: Since 2019, four theme-specific conferences were organized. This report includes evidence from four conferences. The conferences convened researchers and scientists from research and training institutions, implementers, government agencies, and legislators in Tanzania and other countries within and outside Africa. Four hundred and thirty-five abstracts were presented covering 14 sub-themes on health system improvements, financing, governance, prevention intervention, and the role of innovation and technology. The conferences have had a positive effect on governments’ response to NCDs, including health care financing, NCDs research agenda, and universal health coverage. Conclusion: The National NCDs conferences have provided suitable platforms where stakeholders can share, discuss, and recommend vital strategies for addressing the burden of NCDs through informing policies and practices. Ensuring the engagement of the right stakeholders, as well as the uptake and utilization of the recommendations from these platforms, remains crucial for addressing the observed epidemiological transition in Tanzania and other countries with similar contexts

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms leading to this metabolic phenotype are unclear. Here we show that the transcription factor cMyc is essential for IL-2/IL-12-induced metabolic and functional responses in mice. cMyc protein levels are acutely regulated by amino acids; cMyc protein is lost rapidly when glutamine is withdrawn or when system L-amino acid transport is blocked. We identify SLC7A5 as the predominant system L-amino acid transporter in activated NK cells. Unlike other lymphocyte subsets, glutaminolysis and the tricarboxylic acid cycle do not sustain OXPHOS in activated NK cells. Glutamine withdrawal, but not the inhibition of glutaminolysis, results in the loss of cMyc protein, reduced cell growth and impaired NK cell responses. These data identify an essential role for amino acid-controlled cMyc for NK cell metabolism and function