A Response to \u3cem\u3eSherk\u3c/em\u3e: Chagrin without Despair and Hope without Presumption

This article examines defense of misuse under Pennsylvania strict product liability law in light of the Pennsylvania Supreme Court\u27s recent decision in Sherk v. Daisy-Heddon. The author criticizes the plurality opinion and suggests that the approach taken by the dissent represents the ideal in strict product liability law

Book Reviews

THE SUPREME COURT AND RELIGION. By Richard E. Morgan. New York: The Free Press, 1972. Pp. 216. $7.95. WHO RUNS CONGRESS? THE PRESIDENT, BIG BUSINESS, OR You? By Mark J. Green, James M. Fallows and David R. Zwick. New York: Bantam Books and Grossman Publishers, 1972. Pp. 307.$1.95. PRIVATE INTEREST AND PUBLIC GAIN: THE DARTMOUTH COLLEGE CASE, 1819. By Francis N. Stites. Amherst: The University of Massachusetts Press, 1972. Pp. 176. $9.50. JUSTICE IS THE CRIME: PRETRIAL DELAY IN FELONY CASES. By Lewis R. Katz, with Lawrence B. Litwin and Richard H. Bamberger. Cleveland: Case Western Reserve University Press, 1972. Pp. 386.$6.95

Wind Profiles in Tropical Cyclone Stratiform Rainbands over Land

Abstract Observations of 14 stratiform periods in outer tropical cyclone rainbands are used to evaluate wind structure using a velocity–azimuth display (VAD) technique applied to KAMX (Miami) Weather Surveillance Radar-1988 Doppler (WSR-88D) data. These 14 cases occurred over land in southern Florida from Tropical Storm Fay and Hurricanes Gustav and Ike during 2008. Profiles show a maximum horizontal wind speed between 1000 and 1500 m in height, with occasional evidence of a secondary horizontal wind maximum near 3500–5000 m. Storm-relative wind components are calculated, and radial wind profiles show a mean transition from radial inflow at low levels to radial outflow around 2500–3000-m altitude. The radial inflow maximum is around 500 m, while maximum outflow is more variable. These profile characteristics are consistent with previous wind observations in rainbands over land and water. Changes in wind structure within one 4-h period are examined, with changes seen linked to the environmental influence on the rainband. All rainbands show a logarithmic wind speed decrease below 200 m. This layer is studied in detail using a log-wind fit method and a ratio method to calculate aerodynamic roughness length. Much lower ratios of surface to higher-level winds were found than in previous studies over open oceans. Another significant finding of this work is the lack of a constant aerodynamic roughness length despite similar storm wind profiles. These results are useful in broadening the understanding of low-level impacts of landfalling rainbands far from the storm center

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

A number of genetic mutations have been identified in human breast cancers, yet the specific combinations of mutations required in concert to form breast carcinoma cells remain unknown. One approach to identifying the genetic and biochemical alterations required for this process involves the transformation of primary human mammary epithelial cells (HMECs) to carcinoma cells through the introduction of specific genes. Here we show that introduction of three genes encoding the SV40 large-T antigen, the telomerase catalytic subunit, and an H-Ras oncoprotein into primary HMECs results in cells that form tumors when transplanted subcutaneously or into the mammary glands of immunocompromised mice. The tumorigenicity of these transformed cells was dependent on the level of ras oncogene expression. Interestingly, transformation of HMECs but not two other human cell types was associated with amplifications of the c-myc oncogene, which occurred during the in vitro growth of the cells. Tumors derived from the transformed HMECs were poorly differentiated carcinomas that infiltrated through adjacent tissue. When these cells were injected subcutaneously, tumors formed in only half of the injections and with an average latency of 7.5 weeks. Mixing the epithelial tumor cells with Matrigel or primary human mammary fibroblasts substantially increased the efficiency of tumor formation and decreased the latency of tumor formation, demonstrating a significant influence of the stromal microenvironment on tumorigenicity. Thus, these observations establish an experimental system for elucidating both the genetic and cell biological requirements for the development of breast cancer