41 research outputs found
Cantons de Puiseaux, Malesherbes et Pithiviers
Cette nouvelle campagne de prospections aĂ©riennes dans le nord Loiret est dirigĂ©e par Christophe Devilliers avec la collaboration de photographes aĂ©riens : Annick Tardif, Francis Tardif, Sylvain HervĂ©, Charles Kister, Ăric Fortier (SociĂ©tĂ© archĂ©ologique de la rĂ©gion de Puiseaux). Les vols se font Ă lâaide dâULM (bases des DrĂŽles dâOiseaux Ă Marsainvilliers et de la Cailletterie Ă Mondreville). LâannĂ©e 2018 marque le vingtiĂšme anniversaire des prospections aĂ©riennes au sein de lâassociation. C..
Atlas des fermes et villae gallo-romaines de Beauce
2018, Ă©tait la troisiĂšme et derniĂšre annĂ©e de notre PCR. Le travail sâest poursuivi sur son rythme de croisiĂšre. Au cours de cette annĂ©e 2018, 106 notices ont Ă©tĂ© ajoutĂ©es au corpus, essentiellement issues de lâarchĂ©ologie aĂ©rienne, pour les dĂ©partements de lâEure-et-Loir, du Loiret et de lâEssonne. RĂ©mi Ossant et Olivier Marlet ont poursuivi la mise en place du site internet, travail qui a abouti Ă sa mise en ligne sur la plateforme Huma-Num AERBA. Fig. 1 â Carte des sites en fonction de leu..
Neutralising Antibodies against Ricin Toxin
The Centers for Disease Control and Prevention have listed the potential bioweapon ricin as a Category B Agent. Ricin is a so-called A/B toxin produced by plants and is one of the deadliest molecules known. It is easy to prepare and no curative treatment is available. An immunotherapeutic approach could be of interest to attenuate or neutralise the effects of the toxin. We sought to characterise neutralising monoclonal antibodies against ricin and to develop an effective therapy. For this purpose, mouse monoclonal antibodies (mAbs) were produced against the two chains of ricin toxin (RTA and RTB). Seven mAbs were selected for their capacity to neutralise the cytotoxic effects of ricin in vitro. Three of these, two anti-RTB (RB34 and RB37) and one anti-RTA (RA36), when used in combination improved neutralising capacity in vitro with an IC50 of 31 ng/ml. Passive administration of association of these three mixed mAbs (4.7 ”g) protected mice from intranasal challenges with ricin (5 LD50). Among those three antibodies, anti-RTB antibodies protected mice more efficiently than the anti-RTA antibody. The combination of the three antibodies protected mice up to 7.5 hours after ricin challenge. The strong in vivo neutralising capacity of this three mAbs combination makes it potentially useful for immunotherapeutic purposes in the case of ricin poisoning or possibly for prevention
Evaluation nationale des pratiques de prise en charge préhospitaliÚre des traumatisés vertébro-médullaires
DIJON-BU MĂ©decine Pharmacie (212312103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
AMOC Recent and Future Trends: A Crucial Role for Oceanic Resolution and Greenland Melting?
International audienceThe Atlantic Meridional Overturning Circulation (AMOC) is a crucial element of the Earth climate. It is a complex circulation system difficult to monitor and to model. There is considerable debate regarding its evolution over the last century as well as large uncertainty about its fate at the end of this century. We depict here the progress since the IPCC SROCC report, offering an update of its chapter 6.7. We also show new results from a high-resolution ocean model and a CMIP6 model to investigate the impact of Greenland Ice Sheet (GrIS) melting, a key uncertainty for past and future AMOC changes. The ocean-only simulation at 1/24° resolution in the Arctic-North Atlantic Ocean performed over the period 2004â2016 indicates that the spread of the Greenland freshwater runoff toward the center of the Labrador Sea, where oceanic convection occurs, seems larger in this model than in a CMIP6 model. Potential explanations are related to the model spatial resolution and the representation of mesoscale processes, which more realistically transport the freshwater released around the shelves and, through eddies, provides strong lateral exchanges between the fine-scale boundary current and the convective basin in the Labrador Sea. The larger freshening of the Labrador Sea in the high-resolution model then strongly affects deep convection activity. In the simulation including GrIS melting, the AMOC weakens by about 2 Sv after only 13 years, far more strongly than what is found in the CMIP6 model. This difference raises serious concerns on the ability of CMIP6 models to correctly assess the potential impact of GrIS melting on the AMOC changes over the last few decades as well as on its future fate. To gain confidence in the GrIS freshwater impacts on climate simulations and therefore in AMOC projections, urgent progress should be made on the parameterization of mesoscale processes in ocean models
ContrĂŽle santĂ© par fibres optiques de rĂ©servoirs composites pour le stockage dâhydrogĂšne sous haute pression â Projet Horizon HydrogĂšne Ănergie (Projet H2E)
International audienceThis document presents the results of mechanical tests performed on carbon fibre epoxy composite samples of high pressure storage hydrogen vessels, equipped with embedded Optical Fibre Sensors devoted to their Structural Health Monitoring (SHM).Early measurements on flat samples have proved the Fibre Bragg Gratings (FBG) transducers ability to measure strains into such anisotropic materials, and pointed out the optical fibre location importance relative to the structural layers orientations for strain measurements of the structure.Comparative tests on flat samples and NOL rings, with and without embedded optical fibres, did not permit to conclude about any significant intrusive effect of optical fibres on their ultimate tensile strength.Moreover, interpretation in energy of fatigue tests performed on NOL rings, known to be more representative of pressure vessels, have first demonstrated the weakness of the sole interpretation of force measurements which can lead to wrong interpretations, and second the need to accurately control the energy during the first fatigue cycles, since it has a significant effect on the sample fatigue strength.Mechanical tests on vessels first performed to acquire some knowledge about their behaviour, and also to early detect the occurrence of âcriticalâ structural defects, have demonstrated the essential contribution in this application of the Optical Frequency Domain Reflectometry (OFDR) based on Rayleigh backscattering compared to other âtraditionalâ optical techniques, e.g. Brillouin reflectometry.Based on the fact that pressure vessels are subjected to an homogeneous hydrostatic stress (their internal pressure), we demonstrate, according to OFDR measurements on first composite vessels, the ability to detect some structural defects without the need to inflate them at pressures greater than their working pressure, thus reducing the risk of creation or evolution of new or existing internal defects.Besides the fact that these optical measurements provide information of a mechanical nature (i.e. the distributed strain profile all along the optical fibre), they are performed by the same sensor âthe optical fibreâ embedded into the composite structure throughout its lifetime, eliminating by design any measurement dispersion between different sensors.Thus, the optical fibre used in combination with OFDR turns to be a high-end and non-destructive in situ measurement technique for long-term SHM of high pressure vessels
Mirror actively deformed and regulated for applications in space: design and performance
International audienceThe need for both high quality images and lightweight structures is one of the main drivers in space telescope design. An efficient wave-front control system will become mandatory in future large observatories, retaining performance while relaxing specifications in the global system's stability. We present the mirror actively deformed and regulated for applications in space project, which aims to demonstrate the applicability of active optics for future space instrumentation. It has led to the development of a 24-actuator, 90-mm-diameter active mirror, able to compensate for large lightweight primary mirror deformations in the telescope's exit pupil. The correcting system has been designed for expected wavefront errors from 3-m-class lightweight primary mirrors, while also taking into account constraints for space use. Finite element analysis allowed an optimization of the system in order to achieve a precision of correction better than 10 nm rms. A dedicated testbed has been designed to fully characterize the integrated system performance in representative operating conditions. It is composed of: a telescope simulator, an active correction loop, a point spread function imager, and a Fizeau interferometer. All conducted tests demonstrated the correcting mirror performance and has improved this technology maturity to a TRL4. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI
Electrodeposition of NaHAp coatings on CoNiCrMo alloys (NaHAp/CoNiCrMo) and their electrochemical behavior in simulated body fluids solution
International audienceSodium-hydroxyapatite coatings (NaHAp) were electrodeposited on the surface of CoNiCrMo alloys (NaHAp/CoNiCrMo) from an electrolyte solution containing Ca(NO3)2, NH4H2PO4 and NaNO3. The phase structure, composition and morphology of the coatings were studied by X-ray diffraction (XRD), Energy dispersive X-ray spectroscopy (EDX) and Scanning electron microscopy (SEM). The results showed that the obtained coatings were single phase crystals of HAp, with plate shape and that the sodium acts as a doping element in their composition (0.73%). The deposition temperature affected the thickness as well as the phase structure of the coatings. When the deposition temperature increased, the thickness of the coating increased. The XRD results showed that the coating obtained at 50°C was composed of single phase crystals of HAp with the thickness 6.34m. The in vitro test with CoNiCrMo and NaHAp/CoNiCrMo materials in SBF solution was realized with different immersion times. The results showed that the pH of SBF decreased and the mass of materials increased. SEM images prove the formation of apatite on the surface of NaHAp/CoNiCrMo leading to the decrease of the corrosion current density during immersion process in SBF solution