Letter from Albertus C. Van Raalte to His Wife

Rev. Albertus C. Van Raalte reports to his wife about his trials in obtaining more land for the Holland Colony. When he got to Marshall he discovered that land speculators had already taken the land he thought was available for the Colony. He and a lawyer left Marshall and traveled to Grand Rapids to see the owner who relinquished the property. The man who owned the property purchased the land because he was the contractor for a canal. With the help of prominent men in Grand Rapids, the land went back to the state. These are anxious days for Van Raalte but he urges his dear wife not to worry. Van Raalte says much also about the horse he had and its need for rest.https://digitalcommons.hope.edu/vrp_1840s/1156/thumbnail.jp

Letter Fragment from Hendrik P. Scholte to G. Groen Prinsterer

A fragment of a letter of Hendrik P. Scholte to G. Groen van Prinsterer, stating that he has come to the conclusion to emigrate to America where many of the Afscheidenen have gone.https://digitalcommons.hope.edu/vrp_1840s/1092/thumbnail.jp

Letter from E. Van Unen to Waarde Broeder

A letter of E. van Unen to Waar de Broeder. A translated quote of the letter states: Dominee Van Raalte visited us on Thursday and it was especially uplifting. The worthy continues to visit us and displays his loyalty as a servant of the Evangelie and is not ashamed to show his bond/ties with us. The rest of the letter is about how they are often fined and then jailed but they continue to struggle forward.https://digitalcommons.hope.edu/vrp_1830s/1099/thumbnail.jp

Letter from Antonie Brummelkamp to G. Groen van Prinsterer

A letter of Antoine Brununelkamp to G. Groen van Prinsterer about emigration to North America. To give direction to the stream after the dike has been broken will be fruitless work.https://digitalcommons.hope.edu/vrp_1840s/1072/thumbnail.jp

Hemodynamic forces in endothelial dysfunction and vascular aging

Aging is a key risk factor associated with the associated onset of cardiovascular disease. Notably, vascular aging and cardiovascular disease are both with endothelial dysfunction, or a marked decrease in production and bioavailability the vasodilator of nitric oxide (NO). As a result of decreased nitric oxide availability, aging vessels often exhibit endothelial cell senescence and increased oxidative stress. One of the most potent activators of NO production is fluid shear stress produced by blood flow. Interestingly, age-related decrease in NO production partially results from endothelial insensitivity to shear stress. While the endothelial cell response to fluid shear stress has been well characterized in recent years, the exact mechanisms of how the mechanical force of fluid shear stress is converted into intracellular biochemical signals are relatively unknown. Therefore, gaining a better knowledge of mechanosignaling events in endothelial cells may prove to be beneficial for developing potential therapies for cardiovascular diseases

A summary of the 2023 Society of Obstetric Medicine of Australia and New Zealand (SOMANZ) hypertension in pregnancy guideline

Introduction: Hypertensive disorders of pregnancy (HDP) affect up to 10% of all pregnancies annually and are associated with an increased risk of maternal and fetal morbidity and mortality. This guideline represents an update of the Society of Obstetric Medicine of Australia and New Zealand (SOMANZ) guidelines for the management of hypertensive disorders of pregnancy 2014 and has been approved by the National Health and Medical Research Council (NHMRC) under section 14A of the National Health and Medical Research Council Act 1992. In approving the guideline recommendations, NHMRC considers that the guideline meets NHMRC\u27s standard for clinical practice guidelines. Main recommendations: A total of 39 recommendations on screening, preventing, diagnosing and managing HDP, especially preeclampsia, are presented in this guideline. Recommendations are presented as either evidence-based recommendations or practice points. Evidence-based recommendations are presented with the strength of recommendation and quality of evidence. Practice points were generated where there was inadequate evidence to develop specific recommendations and are based on the expertise of the working group. Changes in management resulting from the guideline: This version of the SOMANZ guideline was developed in an academically robust and rigorous manner and includes recommendations on the use of combined first trimester screening to identify women at risk of developing preeclampsia, 14 pharmacological and two non-pharmacological preventive interventions, clinical use of angiogenic biomarkers and the long term care of women who experience HDP. The guideline also includes six multilingual patient infographics which can be accessed through the main website of the guideline. All measures were taken to ensure that this guideline is applicable and relevant to clinicians and multicultural women in regional and metropolitan settings in Australia and New Zealand