Hemodynamic and clinical response to three-day infusion of sulmazol (AR-L 115 BS) in severe congestive heart failure

Sulmazol (AR-L 115 BS) is a new positively inotropic drug with arterial and venous vasodilating properties. We studied the effects of sulmazol (three-day infusion) on clinical tolerance, hemodynamics, and blood gas levels in ten patients with severe chronic heart failure. The hemodynamic monitoring included a Swan-Ganz catheter in the pulmonary artery and a radial catheter. Blood gas levels were determined on samples of arterial and mixed venous blood. After 24 hours of infusion, there was a significant increase in cardiac index (2 to 2.5 L/min/sq m; p<0.005) and a signification decrease in pulmonary-wedge pressure (28 to 19 mm Hg; p<0.001) and in right atrial pressure (7 to 4 mm Hg; p<0.001) without significant changes in heart rate and systolic blood pressure. These benefical effects lasted during the three days of infusion. Oxygen delivery was significantly increased (350 to 443 ml/min/sq m; p<0.005) without significant change in arterial oxygen tension. The side effects included nausea, vomiting, anorexia, and mild thrombocytopenia. We conclude that sulmazol is a potent drug which may improve severely deteriorated left and right ventricular function in patients with chronic refractory heart failure without affecting the heart rate and the systolic blood pressure.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Three-dimensional pseudo-unsteady viscous-inviscid interaction for wings in transonic flow

editorial reviewedAircraft aerodynamic and aeroelastic optimization is applied increasingly often at the preliminary design stage. Performing such optimizations involves many design variables and higher-fidelity solutions of the Reynolds-Averaged Navier-Stokes equations have significant computational cost that is incompatible with repeated application. The tools used to assess the aerodynamic quality of a design within an optimization framework must be computationally efficient. The present work introduces a viscous-inviscid interaction methodology in three dimensions whereby inviscid solutions of the full-potential equation are coupled with a viscous solver based on the integral boundary layer equations. A novel pseudo-unsteady approach is used to ensure numerical stability when considering mildly separated flows and shock waves in the transonic regime. The solvers are coupled through a strip-based methodology in which chordwise boundary layer sections are defined independently of the inviscid unstructured mesh on the surface of the wing. The present methodology is demonstrated for transonic flow over the ONERA M6 and LANN wings. Results show good agreement with reference data on the inboard sections while some discrepancies between the present methodology and higher fidelity data exist in the outboard region of the wings. The methodology is shown to be computationally efficient and suitable for use in an optimization framework

Postnatal ulegyria due to prolonged postoperative status epilepticus

peer reviewe

Caustic intoxication

SCOPUS: cp.jinfo:eu-repo/semantics/publishe