L'allogreffe de moelle dans les hémopathies de l'adulte. L'équipe de l'Unité Stérile.

For severe aplastic anemia and several malignant hemopathies allogeneic bone marrow transplantation is the only treatment with curative potential. This is the case for chronic myelogenous leukemia, the myelodysplastic syndromes and probably multiple myeloma and chronic lymphocytic leukemia. It seems also the best therapeutic option for young adults who suffer from acute leukemia and for whom an adequate family donor is available. We review here the main complications of the procedure. Their better knowledge and the way to prevent and to treat them has decreased the mortality and morbidity of this treatment which is mostly successful when applied on patients in the early phase of their disease. Recently, the availability of HLA typed registered volunteers has extended the applicability of allogeneic bone marrow transplantation for those patients who lack adequate familial donors.SCOPUS: re.jinfo:eu-repo/semantics/publishe

Fièvre chez un patient traité par l'hydréa

info:eu-repo/semantics/publishe

Perspectives in the treatment of hairy cell leukemia

SCOPUS: re.jinfo:eu-repo/semantics/publishe

Chemotherapy of adult acute lymphoblastic leukaemia

SCOPUS: re.jinfo:eu-repo/semantics/publishe

Protected environment and intestinal decontamination in acute leukemia

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Regulation of bone marrow myeloblast proliferation in chronic myeloid leukemia

The in vitro [3 H]thymidine-labeling index of bone marrow myeloblasts and myelocytes was determined for 9 hematologically normal individuals and 20 Ph 1 -positive chronic myeloid leukemia (CML) patients in the chronic phase of their disease. The mean labeling index of myeloblasts from CML patients when the white blood cell (WBC) count was lower than 20,000/cu mm (42.4%) was not significantly different from that of normal myeloblasts (49.9). This index was found to be significantly (p < 0.05) decreased to an average of 20.9% when the WBC count was higher than 40,000/cu mm. The mean labeling index of CML myelocytes was not significantly influenced by the level of WBC. The data presented indicate that such variations in the labeling index of the leukemic myeloblasts represent changes of their proliferative activity related to the level of WBC. It is concluded that the proliferation of CML myeloblasts is sensitive, to a certain degree at least, to the size of the myeloid cell population in the body or a subclass of it. © 1976, American Association for Cancer Research. All rights reserved.SCOPUS: ar.jSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Cyclosporin-associated fatal convulsions

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Empiric therapy for cancer patients: comparative study of ticarcillin tobramycin, ticarcillin cephalothin, and cephalothin tobramycin

Three combinations of antibiotics (cephalothin tobramycin, cephalothin ticarcillin, and ticarcillin tobramycin) were administered empirically to 186 patients with cancer who were suspected of having a life threatening infection. In approximately one half of these patients, gram negative infection was documented bacteriologically and consisted of septicemia in 50% of these patients. The three antimicrobial regimens were similarly effective and resulted in a favorable clinical response in approximately 55% of the patients. The administration of the cephalothin tobramycin combination was associated with a significantly higher frequency of nephrotoxicity than that of the other two regimens.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Clonal origin of a T cell lymphoproliferative malignancy

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

The labelling index of marrow myeloblasts: A predictive test for relapse of acute non-lymphoblastic leukemia

SCOPUS: ar.jinfo:eu-repo/semantics/publishe