Performatives and (im)perfective aspect

Michael Meeuwis, Astrid De Wit & Frank Brisard Performatives and (im)perfective aspect (lecture) This paper represents the first (methodological) step in a cross-linguistic study on the relation between performativity and aspect. It starts from the observation that verbs, when used as performatives, are typically inflected with (present) perfective aspect. This can be motivated on the basis of the indexical quality of performatively used verbs: the activity referred to by performatives (such as I promise to come) can be said to coincide exactly with the act of referring to it. Thus, we may say that the denoted situation (the speech act of promising) is in fact constituted by the speech event (Langacker 2001). As a result, the situation at issue is fully conceptualized at the time of speaking by definition, which would typically trigger perfective aspectual marking: perfective expressions designate situations that are treated as known and closed. Imperfective aspect, in contrast, is associated with construing situations as incomplete and open. For instance, using progressive marking (a kind of imperfective aspect) in an utterance like I’m promising to come has the effect of turning it into a mere description of an ongoing event, thereby canceling its performative character. It is possible, however, that this assumption of a correlation between performativity and perfectivity is biased by a privileging of examples from English, in which performative contexts obligatorily feature the simple present (and the simple present is commonly assumed to have a perfective value; cf. Brinton (1988), Smith (1997: 110-112, 185-186), Williams (2002: 128-166) and De Wit et al. (2013)). However, data from Slavic -- the only language family for which the relation between performativity and aspect has been examined thoroughly (cf. Israeli 2001; Dickey forthcoming) -- indicate an opposite tendency: most Slavic languages, especially from the eastern branch (such as Russian), almost exclusively allow imperfective verbs in performative contexts. Jaggar (2006) furthermore indicates that performative expressions in Hausa trigger both perfective and imperfective marking. The correlation therefore needs to be checked cross-linguistically, an endeavor that requires a suitable questionnaire offering contexts that are universally accepted as triggering performative uses. Our purpose is to present such a questionnaire and to discuss its methodological potential and limitations. A crucial element will be to elicit and identify performatives without having to resort to aspectual tests, such as in English (present simple vs progressive). By wayof a pilot study, we will also offer our first findings based on native speaker elicitations in Lingala, Turkish and Sranan

Performativity, progressive avoidance and aspect

Unlike other reports of ongoing actions, English explicit performatives do not normally take progressive form. This suggests that “there is something over and above a mere concurrent report” in utterances like I bet you I’ll win the race that is absent in utterances like I’m betting you I’ll win the race (Levinson 1983: 259). For Krifka (2014), an explicit performative describes not the utterance act being produced, but the adoption of a new commitment, which has already happened at encoding time. If this is so, however, we might expect to find preterit- or present-perfect-form performative clauses and it appears that we do not. Using cross-linguistic data from genetically and geographically unrelated languages, we establish a strong typological tendency: explicit performative utterances use the same verbal construction that is used for reporting states holding at coding time. We attribute this tendency to an epistemic commonality between explicit performatives and state reports. In addition, we offer an explanation for exceptional uses of progressive aspect in apparently performative expressions, noted by, e.g., Searle (1989). Building on Dahl (1985), we have developed a questionnaire that allows us to identify the aspectual distinctions made in individual languages and which of these categories are employed in the various performative contexts (as classified by Searle 1976). Imperfective aspect is used to encode performatives and present-time states in, e.g., Arabic, Turkish and Bosnian/Croatian/Serbian. In Bantu languages like Lingala and Kirundi, performative predications receive perfective encoding, and this same form is used to report states holding at present. Japanese and the Austronesian language Kilivila feature unmarked verb forms in both present state reports and performative expressions. Progressive aspect is systematically excluded in the languages of our sample. Thus, in light of these typological observations, the use of the English simple present in performative contexts is not unexpected. The fact that present-time states and performative events receive the same aspectual construal across languages suggests a semantic commonality that cannot be conceived in terms of boundedness, one of the major parameters used to describe aspectual distinctions. We argue instead that aspectual categories encode epistemic distinctions, and that states and performative events are similar at this epistemic level: the situation type expressed by a performative or state predication is verifiable at the time of speaking. States have the subinterval property, according to which every segment of a state counts as an instance of that state, including that segment that overlaps the speech event. In the case of performatives, the reporting event and the performed event (promising, etc.) are one and the same; therefore, performative events are verifiable as such at speech time. The few scholars who touch on performativity and aspect in English appear to assume that in the rare attestations of progressive perfomatives, the predication does not perform a speech act (like promising) but rather reports on one’s own performance, as in I’m not just saying, I’m promising (Langacker 1987; Verschueren 1995; Krifka 2014). However, this characterization is not evidently applicable to examples like I’m warning you, Mrs. Hinkle: one more obscenity and I’ll charge you with contempt, which does count as a warning. Analysis of COCA data reveals that one type of performative clause, the exercitive type (Austin 1962), involving verbs such as warn and order, accounts for the majority of progressive performative tokens. Following McGowan (2004), we assume that exercitive acts change the boundaries of permissible or appropriate conduct. We postulate that progressive-form exercitive acts do not change these boundaries but rather describe an effort to do so. More generally, progressive performatives are action glosses like I’m trying to repair this; they explain the purpose of ongoing actions, both linguistic and nonlinguistic. This account naturally extends to non-exercitive progressive performatives like I’m withdrawing as a candidate

Effects of Digested Onion Extracts on Intestinal Gene Expression: An Interspecies Comparison Using Different Intestine Models.

Human intestinal tissue samples are barely accessible to study potential health benefits of nutritional compounds. Numbers of animals used in animal trials, however, need to be minimalized. Therefore, we explored the applicability of in vitro (human Caco-2 cells) and ex vivo intestine models (rat precision cut intestine slices and the pig in-situ small intestinal segment perfusion (SISP) technique) to study the effect of food compounds. In vitro digested yellow (YOd) and white onion extracts (WOd) were used as model food compounds and transcriptomics was applied to obtain more insight into which extent mode of actions depend on the model. The three intestine models shared 9,140 genes which were used to compare the responses to digested onions between the models. Unsupervised clustering analysis showed that genes up- or down-regulated by WOd in human Caco-2 cells and rat intestine slices were similarly regulated by YOd, indicating comparable modes of action for the two onion species. Highly variable responses to onion were found in the pig SISP model. By focussing only on genes with significant differential expression, in combination with a fold change > 1.5, 15 genes showed similar onion-induced expression in human Caco-2 cells and rat intestine slices and 2 overlapping genes were found between the human Caco-2 and pig SISP model. Pathway analyses revealed that mainly processes related to oxidative stress, and especially the Keap1-Nrf2 pathway, were affected by onions in all three models. Our data fit with previous in vivo studies showing that the beneficial effects of onions are mostly linked to their antioxidant properties. Taken together, our data indicate that each of the in vitro and ex vivo intestine models used in this study, taking into account their limitations, can be used to determine modes of action of nutritional compounds and can thereby reduce the number of animals used in conventional nutritional intervention studies

A chemical survey of exoplanets with ARIEL

Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planet’s birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25–7.8 μm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10–100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed – using conservative estimates of mission performance and a full model of all significant noise sources in the measurement – using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL – in line with the stated mission objectives – will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.Peer reviewedFinal Published versio

The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism

Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin’s SMC3 subunit is a dynamic process that involves the acetyltransferase ESCO1 and deacetylase HDAC8. Here we show that this cohesin acetylation cycle controls the three-dimensional genome in human cells. ESCO1 restricts the length of chromatin loops, and of architectural stripes emanating from CTCF sites. HDAC8 conversely promotes the extension of such loops and stripes. This role in controlling loop length turns out to be distinct from the canonical role of cohesin acetylation that protects against WAPL-mediated DNA release. We reveal that acetylation controls the interaction of cohesin with PDS5A to restrict chromatin loop length. Our data support a model in which this PDS5A-bound state acts as a brake that enables the pausing and restart of loop enlargement. The cohesin acetylation cycle hereby provides punctuation in the process of genome folding

Perioperative strategy in colonic surgery; LAparoscopy and/or FAst track multimodal management versus standard care (LAFA trial)

BACKGROUND: Recent developments in large bowel surgery are the introduction of laparoscopic surgery and the implementation of multimodal fast track recovery programs. Both focus on a faster recovery and shorter hospital stay. The randomized controlled multicenter LAFA-trial (LAparoscopy and/or FAst track multimodal management versus standard care) was conceived to determine whether laparoscopic surgery, fast track perioperative care or a combination of both is to be preferred over open surgery with standard care in patients having segmental colectomy for malignant disease. METHODS/DESIGN: The LAFA-trial is a double blinded, multicenter trial with a 2 × 2 balanced factorial design. Patients eligible for segmental colectomy for malignant colorectal disease i.e. right and left colectomy and anterior resection will be randomized to either open or laparoscopic colectomy, and to either standard care or the fast track program. This factorial design produces four treatment groups; open colectomy with standard care (a), open colectomy with fast track program (b), laparoscopic colectomy with standard care (c), and laparoscopic surgery with fast track program (d). Primary outcome parameter is postoperative hospital length of stay including readmission within 30 days. Secondary outcome parameters are quality of life two and four weeks after surgery, overall hospital costs, morbidity, patient satisfaction and readmission rate. Based on a mean postoperative hospital stay of 9 +/- 2.5 days a group size of 400 patients (100 each arm) can reliably detect a minimum difference of 1 day between the four arms (alfa = 0.95, beta = 0.8). With 100 patients in each arm a difference of 10% in subscales of the Short Form 36 (SF-36) questionnaire and social functioning can be detected. DISCUSSION: The LAFA-trial is a randomized controlled multicenter trial that will provide evidence on the merits of fast track perioperative care and laparoscopic colorectal surgery in patients having segmental colectomy for malignant disease

Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids

A hexanucleotide repeat expansion (HRE) in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Human brain imaging and experimental studies indicate early changes in brain structure and connectivity in C9-ALS/FTD, even before symptom onset. Because these early disease phenotypes remain incompletely understood, we generated iPSC-derived cerebral organoid models from C9-ALS/FTD patients, presymptomatic C9ORF72-HRE (C9-HRE) carriers, and controls. Our work revealed the presence of all three C9-HRE-related molecular pathologies and developmental stage-dependent size phenotypes in cerebral organoids from C9-ALS/FTD patients. In addition, single-cell RNA sequencing identified changes in cell type abundance and distribution in C9-ALS/FTD organoids, including a reduction in the number of deep layer cortical neurons and the distribution of neural progenitors. Further, molecular and cellular analyses and patch-clamp electrophysiology detected various changes in synapse structure and function. Intriguingly, organoids from all presymptomatic C9-HRE carriers displayed C9-HRE molecular pathology, whereas the extent to which more downstream cellular defects, as found in C9-ALS/FTD models, were detected varied for the different presymptomatic C9-HRE cases. Together, these results unveil early changes in 3D human brain tissue organization and synaptic connectivity in C9-ALS/FTD that likely constitute initial pathologies crucial for understanding disease onset and the design of therapeutic strategies

Treatment of vestibular disorders with weak asymmetric base-in prisms: An hypothesis with a focus on Ménière’s disease

BACKGROUND: Regular treatments of Ménière's disease (MD) vary largely, and no single satisfactory treatment exists. A complementary treatment popular among Dutch and Belgian patients involves eyeglasses with weak asymmetric base-in prisms, with a perceived high success rate. An explanatory mechanism is, however, lacking. OBJECTIVE: To speculate on a working mechanism explaining an effectiveness of weak asymmetric base-in prims in MD, based on available knowledge. METHODS: After describing the way these prisms are prescribed using a walking test and its effect reported on, we give an explanation of its underlying mechanism, based on the literature. RESULTS: The presumed effect can be explained by considering the typical star-like walking pattern in MD, induced by a drifting after-image comparable to the oculogyral illusion. Weak asymmetric base-in prisms can furthermore eliminate the conflict between a net vestibular angular velocity bias in the efferent signal controlling the VOR, and a net re-afferent ocular signal. CONCLUSIONS: The positive findings with these glasses reported on, the fact that the treatment itself is simple, low-cost, and socially acceptable, and the fact that an explanation is at hand, speak in favour of elaborating further on this treatment

Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants

© The Author(s) 2018. Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups