The vertical line indicates the actual position of the simulated gene and horizontal lines correspond to the threshold values given by one--score drop from the peak of the curves

<p><b>Copyright information:</b></p><p>Taken from "Linkage analysis of complex diseases using microsatellites and single-nucleotide polymorphisms: application to alcoholism"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S10-S10.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866840.</p><p></p> The -values corresponding to the highest peaks are 0.005 for microsatellites and 2 × 10to 7 × 10for different panels of SNPs

Additional file 2: of Pancreatic cancer as a sentinel for hereditary cancer predisposition

Figure S1. The pancreatic cancer cases with Utah Population Database (UPDB) genealogies with cancer information. (JPG 847 kb

Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies-2

<p><b>Copyright information:</b></p><p>Taken from "Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies"</p><p>http://www.biomedcentral.com/1471-2164/8/299</p><p>BMC Genomics 2007;8():299-299.</p><p>Published online 30 Aug 2007</p><p>PMCID:PMC2072960.</p><p></p> bottom of each panel

Additional file 3: of Pancreatic cancer as a sentinel for hereditary cancer predisposition

Table S4. Is a list of reports/genes used for meta-analysis. Table S5. is the values that were used to create Fig. 3. (DOCX 34 kb

Additional file 1: of Pancreatic cancer as a sentinel for hereditary cancer predisposition

Table S1. contains the list of the genes used in the study, as well as indicators for which pathway they belong to in subsequent analyses. Table S2. is the list of rare variants with corresponding in silico scores. Table S3. contains the total counts that were used to create Fig. 2. (XLSX 73 kb

Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies-3

<p><b>Copyright information:</b></p><p>Taken from "Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies"</p><p>http://www.biomedcentral.com/1471-2164/8/299</p><p>BMC Genomics 2007;8():299-299.</p><p>Published online 30 Aug 2007</p><p>PMCID:PMC2072960.</p><p></p

Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies-0

<p><b>Copyright information:</b></p><p>Taken from "Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies"</p><p>http://www.biomedcentral.com/1471-2164/8/299</p><p>BMC Genomics 2007;8():299-299.</p><p>Published online 30 Aug 2007</p><p>PMCID:PMC2072960.</p><p></p

SNP Filtering Summary.

<p>Variant filtering representation through the number of SNPs remaining after the various filtering steps.</p><p>The Average and Percentage remaining rows represent the average number of variants and percentage of variants remaining per family.</p>a<p>Intronic, intergenic and synonymous variants were discarded. See methods.</p>b<p>Detailed criteria for these filters is reported on the methods section.</p>c<p>Number of variants shared between the two individuals in the family.</p>d<p>Total number of final variants for all the individuals in this study.</p

Final Candidate Variants.

<p>List of final candidate variants passing all filters.</p>a<p>Chromosome in which the variant was mapped.</p>b<p>Position according to the coordinate system (HG18).</p>c<p>Variant consequence: NS = non-synonymous variant UTR3 = 3′ untranslated region variant.</p>d<p>Fisher’s Exact Test P value.</p>e<p>Odds Ratio.</p>f<p>95% confidence interval for the Odds Ratio.</p><p>N/A = not available.</p

INDEL Filtering Summary.

<p>Variant filtering representation through the number of INDELs remaining after the various filtering steps.</p><p>The Average and Percentage remaining rows represent the average number of variants and percentage of variants remaining per family.</p>a<p>Intronic and intergenic variants were discarded. See methods.</p>b<p>Detailed criteria for these filters is reported on the methods section.</p>c<p>Number of variants shared between the two individuals in the family.</p>d<p>Total number of final variants for all the individuals in this study.</p