On the Mean Residence Time in Stochastic Lattice-Gas Models

A heuristic law widely used in fluid dynamics for steady flows states that the amount of a fluid in a control volume is the product of the fluid influx and the mean time that the particles of the fluid spend in the volume, or mean residence time. We rigorously prove that if the mean residence time is introduced in terms of sample-path averages, then stochastic lattice-gas models with general injection, diffusion, and extraction dynamics verify this law. Only mild assumptions are needed in order to make the particles distinguishable so that their residence time can be unambiguously defined. We use our general result to obtain explicit expressions of the mean residence time for the Ising model on a ring with Glauber + Kawasaki dynamics and for the totally asymmetric simple exclusion process with open boundaries

Strategies for fast convergence in semiotic dynamics

Semiotic dynamics is a novel field that studies how semiotic conventions spread and stabilize in a population of agents. This is a central issue both for theoretical and technological reasons since large system made up of communicating agents, like web communities or artificial embodied agents teams, are getting widespread. In this paper we discuss a recently introduced simple multi-agent model which is able to account for the emergence of a shared vocabulary in a population of agents. In particular we introduce a new deterministic agents' playing strategy that strongly improves the performance of the game in terms of faster convergence and reduced cognitive effort for the agents.Comment: 6 pages, 6 figure

Three-field mixed formulation for the non-linear analysis of composite beams with deformable shear connection

A three-eld mixed nite element is proposed for the non-linear analysis of composite beam with deformable shear connection. The formulation considers the non-linear behaviour of materials and shear connectors. The established mixed element is compared to the locking-free displacement element from which it derives and to a rened locking-free displacement element previously tested by the authors. In order to evaluate the way to better improve the solution in the non-linear range (three-eld mixed formulation or rened displacement formulation), numerical applications are performed using, as working example, a steel- oncrete cantilever, representing a di3cult test for composite beam elements

Seismic Response Analysis of Continuous Multispan Bridges with Partial Isolation

Partially isolated bridges are a particular class of bridges in which isolation bearings are placed only between the piers top and the deck whereas seismic stoppers restrain the transverse motion of the deck at the abutments. This paper proposes an analytical formulation for the seismic analysis of these bridges, modelled as beams with intermediate viscoelastic restraints whose properties describe the pier-isolator behaviour. Different techniques are developed for solving the seismic problem. The first technique employs the complex mode superposition method and provides an exact benchmark solution to the problem at hand. The two other simplified techniques are based on an approximation of the displacement field and are useful for preliminary assessment and design purposes. A realistic bridge is considered as case study and its seismic response under a set of ground motion records is analyzed. First, the complex mode superposition method is applied to study the characteristic features of the dynamic and seismic response of the system. A parametric analysis is carried out to evaluate the influence of support stiffness and damping on the seismic performance. Then, a comparison is made between the exact solution and the approximate solutions in order to evaluate the accuracy and suitability of the simplified analysis techniques for evaluating the seismic response of partially isolated bridges

Assessment of optimal design methods of viscous dampers

Viscous dampers are often used for seismic protection and performance enhancement of building frames. The optimal design of such devices requires the modelling and propagation of the uncertainties related to the earthquake hazard. Different approaches are available for the seismic input characterisation and for the probabilistic response evaluation. This work analyzes the effect of different characterizations of the seismic input and of the response evaluation on the design of dampers for building frames. The seismic input is represented as a stochastic process and the optimal damper properties are found via a reliability-based design procedure aiming at controlling the frame performance while limiting the damper cost. Two simplified approaches are used to design the viscous damper of a multi-storey steel frame and the design results are compared with those obtained by considering a rigorous design approach resorting to advanced simulations for the response assessment. The first methodology evaluates the response through a prefixed probabilistic demand model, while the second approach considers the average response for a given hazard level only. The comparison allows to evaluate and quantify the effect of the seismic input uncertainty treatment on the system and damper performances

Optimality in self-organized molecular sorting

We introduce a simple physical picture to explain the process of molecular sorting, whereby specific proteins are concentrated and distilled into submicrometric lipid vesicles in eukaryotic cells. To this purpose, we formulate a model based on the coupling of spontaneous molecular aggregation with vesicle nucleation. Its implications are studied by means of a phenomenological theory describing the diffusion of molecules towards multiple sorting centers that grow due to molecule absorption and are extracted when they reach a sufficiently large size. The predictions of the theory are compared with numerical simulations of a lattice-gas realization of the model and with experimental observations. The efficiency of the distillation process is found to be optimal for intermediate aggregation rates, where the density of sorted molecules is minimal and the process obeys simple scaling laws. Quantitative measures of endocytic sorting performed in primary endothelial cells are compatible with the hypothesis that these optimal conditions are realized in living cells

COVID-19 and Gestational Diabetes: The Role of Nutrition and Pharmacological Intervention in Preventing Adverse Outcomes

Pregnant women with GDM affected by COVID-19 seem to be at higher risk of adverse maternal and neonatal outcomes, especially those with overweight or obesity. Good glycemic control seems to be the most effective measure in reducing the risk of GDM and severe COVID-19. For such purposes, the Mediterranean diet, micronutrient supplementation, and physical activity are considered the first line of treatment. Failure to achieve glycemic control leads to the use of insulin, and this clinical scenario has been shown to be associated with an increased risk of adverse maternal and neonatal outcomes. In this review, we explore the current evidence pertaining to the pathogenesis of SARS-CoV-2 leading to the main complications caused by COVID-19 in patients with GDM. We also discuss the incidence of complications caused by COVID-19 in pregnant women with GDM according to their treatment

Analysis and comparison of two different configurations of external dissipative systems

This paper deals with the seismic protection of existing buildings, especially r.c. frame ones, by means of external passive dissipative systems. These type of systems provide larger flexibility in controlling the structural behavior, and some feasibility advantages, but their efficiency in terms of performance still need to be proven. In particular, this study analyzes and compares the performance of two external solutions using linear fluid viscous dampers (FVDs) for the seismic upgrading of an existing benchmark structure, the Van Nuys building. The first arrangement is a recent solution, known as "Dissipative Tower", which exploits the rocking motion of a steel truss hinged at the foundation level for the dampers activation; the second one consists in coupling the building with an external stiff contrasting structure, where the dampers are located horizontally at the storey level. First, a state space formulation of the problem, based on the assumption of linear elastic behavior for both the existing frame and the external dissipative structures, is presented in general terms. The proposed formulation, suitable for both the external arrangements, allows to evaluate the influence of the dissipative solutions on the system modal properties. Successively, the performance of the two proposed external passive structures, is evaluated and compared with that of the bare existing frame, by considering important engineering demand parameters (EDPs) such as interstorey drifts, absolute accelerations and shear actions resisted by the frame and by external systems