Functional Planning and Design of a Fan Shaped Technical Museum

ABSTRACT The proposed building aims at the development of the built environment. The principal objective of this paper is the functional planning, analysis and design of a fan shaped technical museum. Technical museum is a museum that tells the stories of architecture, engineering and design. The functional planning was done according to the clauses given by Museum Building Design and Exhibition Layout: Patterns of Interactions, ICOM Code of Ethics for Museum, and Key Concepts of Museology. Plan, elevation and section were drawn in AutoCAD 2010. The design involves load calculations and analyzing the whole structure by STAAD.ProV8i. The design methods used in STAAD.ProV8i analysis are limit state design conforming to Indian Standard Code of practice. Also the building was analyzed for all possible load combinations

Syndromics: A Bioinformatics Approach for Neurotrauma Research

Substantial scientific progress has been made in the past 50 years in delineating many of the biological mechanisms involved in the primary and secondary injuries following trauma to the spinal cord and brain. These advances have highlighted numerous potential therapeutic approaches that may help restore function after injury. Despite these advances, bench-to-bedside translation has remained elusive. Translational testing of novel therapies requires standardized measures of function for comparison across different laboratories, paradigms, and species. Although numerous functional assessments have been developed in animal models, it remains unclear how to best integrate this information to describe the complete translational “syndrome” produced by neurotrauma. The present paper describes a multivariate statistical framework for integrating diverse neurotrauma data and reviews the few papers to date that have taken an information-intensive approach for basic neurotrauma research. We argue that these papers can be described as the seminal works of a new field that we call “syndromics”, which aim to apply informatics tools to disease models to characterize the full set of mechanistic inter-relationships from multi-scale data. In the future, centralized databases of raw neurotrauma data will enable better syndromic approaches and aid future translational research, leading to more efficient testing regimens and more clinically relevant findings

Assessing the Microbial Community and Functional Genes in a Vertical Soil Profile with Long-Term Arsenic Contamination

Conceived and designed the experiments: GW. Performed the experiments: JX GL. Analyzed the data: JX JZ GW. Contributed reagents/materials/analysis tools: ST JZ GW. Wrote the paper: JX ZH JDVN JZ GW.Arsenic (As) contamination in soil and groundwater has become a serious problem to public health. To examine how microbial communities and functional genes respond to long-term arsenic contamination in vertical soil profile, soil samples were collected from the surface to the depth of 4 m (with an interval of 1 m) after 16-year arsenic downward infiltration. Integrating BioLog and functional gene microarray (GeoChip 3.0) technologies, we showed that microbial metabolic potential and diversity substantially decreased, and community structure was markedly distinct along the depth. Variations in microbial community functional genes, including genes responsible for As resistance, carbon and nitrogen cycling, phosphorus utilization and cytochrome c oxidases were detected. In particular, changes in community structures and activities were correlated with the biogeochemical features along the vertical soil profile when using the rbcL and nifH genes as biomarkers, evident for a gradual transition from aerobic to anaerobic lifestyles. The C/N showed marginally significant correlations with arsenic resistance (p = 0.069) and carbon cycling genes (p = 0.073), and significant correlation with nitrogen fixation genes (p = 0.024). The combination of C/N, NO3− and P showed the highest correlation (r = 0.779, p = 0.062) with the microbial community structure. Contradict to our hypotheses, a long-term arsenic downward infiltration was not the primary factor, while the spatial isolation and nutrient availability were the key forces in shaping the community structure. This study provides new insights about the heterogeneity of microbial community metabolic potential and future biodiversity preservation for arsenic bioremediation management.Yeshttp://www.plosone.org/static/editorial#pee

Role of high-frequency USG in rotator cuff injury and its comparison with MRI

Introduction: Rotator cuff injury is one of the common causes of long-term shoulder pain and disability encountered in the orthopedic clinic. The spectrum of rotator cuff injury includes tendonitis, partial tears, and complete tears. They also may influence the development of the degenerative disease of glenohumeral joint and rotator cuff arthropathy. Material and Methods: The present, prospective study entitled “Role of high-frequency USG in rotator cuff injury and its comparison with MRI” was conducted in the Department of Radiodiagnosis on a total of 100 patients who presented with signs and symptoms of shoulder joint injury in Department of Orthopedic who were then referred for USG and MRI examination to the Department of Radiodiagnosis. Result: Mean age of the patients was 38.26±14.51 years and the majority of patients belonged to the 3rd decade (34%). About 7% of patients belonged to the 2nd decade, 18% of patients each belonged to the 4th and 5th decades of age group. Only 8% and 7% of patients in the present study belonged to extremes of age i.e. >60 years and <20 years respectively. Conclusion: Based on the findings of the present study, it is concluded that rotator cuff injuries are commonly encountered conditions in routine practice, and males are commonly affected as compared to females