EU Marine Beach Litter Baselines

Measures against marine litter require quantitative data for the assessment of litter abundance, trends and distribution. While beach litter monitoring has been ongoing in some European areas since years, so far it was yet not possible to obtain an overview and to analyse litter abundance, litter category distribution and trends at the different spatial scales from local to EU. Therefore, the EU Marine Directors and the Marine Strategy Coordination Group mandated, in the context of the MSFD implementation, to the MSFD Technical Group on Marine Litter and the JRC, the compilation and analysis of an EU beach litter dataset. Aim was to derive EU Marine Beach Litter Baselines at different spatial levels. After collection of European beach litter data from EU Member States via the EMODNET chemistry module database, harmonisation of data formats, clean-up a 2012-2016 dataset was derived. Following the spatio-temporal aggregation of data and the identification of possible litter category analysis, different scenarios for baseline setting have been tested and evaluated. The application of agreed scenario parameters has enabled the calculation of marine beach litter baselines for the years 2015 and 2016 at spatial scales ranging from country and country –region level to sub-regional, regional and EU level. Litter categories have been aggregated and allow analysis of group categories up to EU level, whereas the analysis of single categories could not include all received data due to non-comparable litter type category descriptions. The resulting set of baselines enables the future monitoring of progress in reduction, as well as compliance checking developed using the dataset. Furthermore, it provides valuable information for future improving harmonised monitoring through updated guidance, common data treatment and agreed data reporting formats. Beach litter abundance has been found to be very high in large areas of Europe, requiring joint and strong action in Europe and with the neighbours in shared marine basins.JRC.D.2-Water and Marine Resource

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

EMODnet marine litter data management at pan-European scale

Marine litter is a growing problem for environmental and human health and policies have included monitoring as an important tool to evaluate both trends and the efficiency of reduction measures. The Marine Strategy Framework Directive is the main driver in Europe for the monitoring of the marine environment; it has included the evaluation of marine litter in order to support policies and achieve good environmental status. This assessment depends on the availability of robust, homogeneous data-sets at the European scale. A data management plan for marine litter has been developed at European level within the existing EMODnet network to collect, homogenise and provide access to standardised data-sets and data products that may be used as a basis for marine litter assessment at pan-European scale. As a long term perspective, it also provides a scientific and technical basis for further global monitoring

Physical and biogeochemical parameters of the Mediterranean Sea during a cruise with RV Maria S. Merian in March 2018

The last few decades have seen dramatic changes in the hydrography and biogeochemistry of the Mediterranean Sea. The complex bathymetry and highly variable spatial and temporal scales of atmospheric forcing, convective and ventilation processes contribute to generate complex and unsteady circulation patterns and significant variability in biogeochemical systems. Part of the variability of this system can be influenced by anthropogenic contributions. Consequently, it is necessary to document details and to understand trends in place to better relate the observed processes and to possibly predict the consequences of these changes. In this context we report data from an oceanographic cruise in the Mediterranean Sea on the German research vessel Maria S. Merian (MSM72) in March 2018. The main objective of the cruise was to contribute to the understanding of long-term changes and trends in physical and biogeochemical parameters, such as the anthropogenic carbon uptake and to further assess the hydrographical situation after the major climatological shifts in the eastern and western part of the basin, known as the Eastern and Western Mediterranean Transients. During the cruise, multidisciplinary measurements were conducted on a predominantly zonal section throughout the Mediterranean Sea, contributing to the Med-SHIP and GO-SHIP long-term repeat cruise section that is conducted at regular intervals in the Mediterranean Sea to observe changes and impacts on physical and biogeochemical variables

The European Marine Observation and Data Network (EMODnet): Visions and Roles of the Gateway to Marine Data in Europe

Marine data are needed for many purposes: for acquiring a better scientific understanding of the marine environment, but also, increasingly, as marine knowledge for decision making as well as developing products and services supporting economic growth. Data must be of sufficient quality to meet the specific users' needs. It must also be accessible in a timely manner. And yet, despite being critical, this timely access to known-quality data proves challenging. Europe's marine data have traditionally been collected by a myriad of entities with the result that much of our data are scattered throughout unconnected databases and repositories. Even when data are available, they are often not compatible, making the sharing of the information and data aggregation particularly challenging. In this paper, we present how the European Marine Observation and Data network (EMODnet) has developed over the last decade to tackle these issues. Today, EMODnet is comprised of more than 150 organizations which gather marine data, metadata, and data products and make them more easily accessible for a wider range of users. EMODnet currently consists of seven sub-portals: bathymetry, geology, physics, chemistry, biology, seabed habitats, and human activities. In addition, Sea-basin Checkpoints have been established to assess the observation capacity in the North Sea, Mediterranean, Atlantic, Baltic, Artic, and Black Sea. The Checkpoints identify whether the observation infrastructure in Europe meets the needs of users by undertaking a number of challenges. To complement this, a Data Ingestion Service has been set up to tackle the problem of the wealth of marine data that remain unavailable, by reaching out to data holders, explaining the benefits of sharing their data and offering a support service to assist them in releasing their data and making them available through EMODnet. The EMODnet Central Portal (www.emodnet.eu) provides a single point of access to these services, which are free to access and use. The strategic vision of EMODnet in the next decade is also presented, together with key focal areas toward a more user-oriented service, including EMODnet for business, internationalization for global users, and stakeholder engagement to connect the diverse communities across the marine knowledge value chain

Risk factors for unfavourable postoperative outcome in patients with Crohn's disease undergoing right hemicolectomy or ileocaecal resection. An international audit by ESCP and S-ECCO

Aim: Patient- and disease-related factors, as well as operation technique, all have the potential to impact on postoperative outcome in Crohn's disease. The available evidence is based on small series and often displays conflicting results. The aim was to investigate the effect of preoperative and intra-operative risk factors on 30-day postoperative outcome in patients undergoing surgery for Crohn's disease. Method: This was an international prospective snapshot audit including consecutive patients undergoing right hemicolectomy or ileocaecal resection. The study analysed a subset of patients who underwent surgery for Crohn's disease. The primary outcome measure was the overall Clavien\u2013Dindo postoperative complication rate. The key secondary outcomes were anastomotic leak, reoperation, surgical site infection and length of stay in hospital. Multivariable binary logistic regression analyses were used to produce odds ratios and 95% confidence intervals. Results: In all, 375 resections in 375 patients were included. The median age was 37 and 57.1% were women. In multivariate analyses, postoperative complications were associated with preoperative parenteral nutrition (OR 2.36, 95% CI 1.10\u20134.97), urgent/expedited surgical intervention (OR 2.00, 95% CI 1.13\u20133.55) and unplanned intra-operative adverse events (OR 2.30, 95% CI 1.20\u20134.45). The postoperative length of stay in hospital was prolonged in patients who received preoperative parenteral nutrition (OR 31, 95% CI 1.08\u20131.61) and those who had urgent/expedited operations (OR 1.21, 95% CI 1.07\u20131.37). Conclusion: Preoperative parenteral nutritional support, urgent/expedited operation and unplanned intra-operative adverse events were associated with unfavourable postoperative outcome. Enhanced preoperative optimization and improved planning of operation pathways and timings may improve outcomes for patients