Structural and ultrastructural modifications of cryptorchid human testes

Structural and ultrastructural modifications have been studied in cryptorchid testes. Biopsies were obtained from 15 patients between 2 and 39 years old, including 7 who had been treated previously by hormonal therapy without success. The most considerable observations were 1) the precocity of damage in germinal epithelium and in peritubular connective tissue, 2) the presence of frequent bilateral damage in cases of unilateral cryptorchidism and 3) the inefficacy of hormonal treatment (human chorionic gonadotropin) on the delay in maturation of tubular epithelium. These findings offer further information about the optimal time for surgical treatment of cryptorchidism, which in our opinion should be done when the patient is less than 2 years old

Effects of peripheral duct occlusion on exocrine and endocrine pancreas. A histological, immunocytochemical and electron-microscopic study in the pig

The effects of central and peripheral duct occlusion on the pancreas of the pig were investigated. The occlusion was obtained by injecting into the distal part of the pancreatic duct an ether diluted delicron or a fluid silicone solution. The pancreatic duct was then interrupted. At different intervals, gross morphology of the residual pancreas was studied and specimens were obtained for histology, immunocytochemistry and electronmicroscopy. A rapid progression of sclerotic modifications, with gradual destruction of exocrine gland, substantially concluded after 60 days, was demonstrated. However Langerhans' islets appeared preserved. These findings permit to suggest the application of this valid experimental model of chronic pancreatitis to the conservative treatment of human chronic pancreatitis

Effects of peripheral duct occlusion on exocrine and endocrine pancreas. A histological, immunocytochemical and electron-microscopic study in the pig

The effects of central and peripheral duct occlusion on the pancreas of the pig were investigated. The occlusion was obtained by injecting into the distal part of the pancreatic duct an ether diluted delicron or a fluid silicone solution. The pancreatic duct was then interrupted. At different intervals, gross morphology of the residual pancreas was studied and specimens were obtained for histology, immunocytochemistry and electronmicroscopy. A rapid progression of sclerotic modifications, with gradual destruction of exocrine gland, substantially concluded after 60 days, was demonstrated. However Langerhans' islets appeared preserved. These findings permit to suggest the application of this valid experimental model of chronic pancreatitis to the conservative treatment of human chronic pancreatitis