Accelerating Scientific Discovery by Formulating Grand Scientific Challenges

One important question for science and society is how to best promote scientific progress. Inspired by the great success of Hilbert's famous set of problems, the FuturICT project tries to stimulate and focus the efforts of many scientists by formulating Grand Challenges, i.e. a set of fundamental, relevant and hardly solvable scientific questions.Comment: To appear in EPJ Special Topics. For related work see http://www.futurict.eu and http://www.soms.ethz.c

Structural basis of complement membrane attack complex formation

In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a ‘multi-hit’ mechanism; however, sublytic MAC pores on host cells activate signalling pathways. Previous studies have described the structures of individual MAC components and subcomplexes; however, the molecular details of its assembly and mechanism of action remain unresolved. Here we report the electron cryo-microscopy structure of human MAC at subnanometre resolution. Structural analyses define the stoichiometry of the complete pore and identify a network of interaction interfaces that determine its assembly mechanism. MAC adopts a ‘split-washer’ configuration, in contrast to the predicted closed ring observed for perforin and cholesterol-dependent cytolysins. Assembly precursors partially penetrate the lipid bilayer, resulting in an irregular β-barrel pore. Our results demonstrate how differences in symmetric and asymmetric components of the MAC underpin a molecular basis for pore formation and suggest a mechanism of action that extends beyond membrane penetration

Accretion column eclipses in the X-ray pulsars GX 1+4 and RX J0812.4-3114

Sharp dips observed in the pulse profiles of three X-ray pulsars (GX 1+4, RX J0812.4-3114 and A 0535+26) have previously been suggested to arise from partial eclipses of the emission region by the accretion column occurring once each rotation period. We present pulse-phase spectroscopy from Rossi X-ray Timing Explorer satellite observations of GX 1+4 and RX J0812.4-3114 which for the first time confirms this interpretation. The dip phase corresponds to the closest approach of the column axis to the line of sight, and the additional optical depth for photons escaping from the column in this direction gives rise to both the decrease in flux and increase in the fitted optical depth measured at this phase. Analysis of the arrival time of individual dips in GX~1+4 provides the first measurement of azimuthal wandering of a neutron star accretion column. The column longitude varies stochastically with standard deviation 2-6 degrees depending on the source luminosity. Measurements of the phase width of the dip both from mean pulse profiles and individual eclipses demonstrates that the dip width is proportional to the flux. The variation is consistent with that expected if the azimuthal extent of the accretion column depends only upon the Keplerian velocity at the inner disc radius, which varies as a consequence of the accretion rate Mdot.Comment: 7 pages, 5 figures, accepted by MNRAS. Included reference

INCREASES IN COSTS AND RETURNS DUE TO INTENSIFYING RANGE FORAGE PRODUCTION SURVEYS: AN INFORMATION ECONOMIC ANALYSIS

The U.S. Congress and courts have directed federal natural resource agencies to use better information for management decisions than they have used in the past. It is also important for these agencies to improve the efficiency of resource use where possible. This information economics study estimates increased costs and revenues which can be directly imputed to improving the accuracy of range forage production surveys. It suggests that a high level of survey accuracy may often be justifiable.Crop Production/Industries, Research Methods/ Statistical Methods,

A high stability optical shadow sensor with applications for precision accelerometers

Displacement sensors are found in a variety of applications including gravitational wave detectors, precision metrology, tissue imaging, gravimeters, microscopy, and environmental monitoring. Most of these applications benefit from the use of displacement sensors that offer both high precision and stability. This is particularly the case for gravimetry where measurements are often taken over multi-day timescales. In this paper we describe a custom-built microcontroller-based displacement sensor that has been utilized in a micro-electromechanicalsystem gravimeter. The system runs off battery power and is low-cost, portable, and lightweight. Using an optical shadow sensor technique, and by designing a digital lock-in amplier based around a dsPIC33 microcontroller, we demonstrate a displacement sensitivity of 10 nm/Hz down to 300 s, and an rms sensitivity of 1 nm over timescales of one day. The system also provides real time monitoring/control of temperature, using an AD7195 ratiometric bridge to provide mK control of three separate PT100 sensors. Furthermore, a tilt sensor conditioning circuit is incorporated to drive a pair of electrolytic tilt sensors, resulting in the ability to monitor 2 axis tilt at the level of 1 microradian over approximately 1 day. The sensor system described is thus multifunctional and capable of being incorporated into precision accelerometers/gravimeters, or indeed other applications where long term displacement/temperature monitoring is necessary

Ground-based photometry of the 21-day Neptune HD106315c

Space-based transit surveys such as K2 and TESS allow the detection of small transiting planets with orbital periods beyond 10 days. Few of these warm Neptunes are currently known around stars bright enough to allow for detailed follow-up observations dedicated to their atmospheric characterization. The 21-day period and 3.95 $R_\oplus$ planet HD106315c has been discovered based on the observation of two of its transits by K2. We have observed HD106315 using the 1.2m Euler telescope equipped with the EulerCam camera on two instances to confirm the transit using broad band photometry and refine the planetary period. Based on two observed transits of HD106315c, we detect its $\sim$1 mmag transit and obtain a precise measurement of the planetary ephemerids, which are critical for planning further follow-up observations. We have used the attained precision together with the predicted yield from the TESS mission to evaluate the potential for ground-based confirmation of Neptune-sized planets found by TESS. We find that 1-meter-class telescopes on the ground equipped with precise photometers could substantially contribute to the follow-up of 162 TESS candidates orbiting stars with magnitudes of $V \leq 14$. Out of these, 74 planets orbit stars with $V \leq 12$ and 12 planets orbit $V \leq 10$, which makes these candidates high-priority objects for atmospheric characterization with high-end instrumentation.Comment: Published in A&A letters, 4 pages, 3 figure