Means to Achieve Sustained Release of Synergistic Drugs by Conjugation

A codrug composition of at least two drug compounds covalently linked to one another via a labile bond to form a single codrug composition, or ionically linked to one another to form a single workings composition, and methods of use of the codrug for the treatment of various medical conditions. The codrug may be administered by itself or in the form of a bioerodible or nonbioerodible substance

Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Oxaalkanoic Acids

The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof

Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Oxaalkanoic Acids

The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof

Permeable, Non-irritating Prodrugs of Nonsteroidal and Steroidal Agents

Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trihydroxy steroids, and flurbiprofen molecules linked to polyethylene glycol (PEG) groups. Pharmaceutical compositions containing these prodrugs, and a method of using these esters for treating disease states or symptoms are also described

Selective membrane transport of dicarboxylic acids in their neutral form by a synthetic receptor containing amidopyridine groups

A synthetic receptor that can discriminate dicarboxylic acids based on host-guest principles has been prepared. This compound incorporates two amidopyridine units as hydrogen-bonding centers that are capable of binding the carboxylic acid functional group. The receptor was dissolved in a kerosene/dodecanol mixture and used as a carrier in supported liquid membranes. Facilitated transport based on the liquid-liquid distribution of dicarboxylic acids between aqueous feed and stripping solutions and an organic phase containing the carrier was accomplished. This transport was driven by a pH gradient that assures the predominance of the protonated neutral form of the carboxylic acids in the feed solution and the corresponding deprotonated form in the stripping solution. Selective transport of dicarboxylic acids was observed allowing for an efficient separation of different carboxylic acids

Tuning the Structure of Lariat Crown Ethers for Ion‐Selective Electrodes: Significant Shifts in Sodium/Potassium Selectivity

Lariat crown ethers (LCEs) offer the ability to bind selectively alkali metal ions. The presence of a coordinating functionality in the sidearm chain provides a means to further tune the selectivity of LCEs. A series of four LCEs based on a 15‐crown‐5 structural motif were synthesized with variations in the coordinating functionality of the sidearm and the substitution at the carbon pivot atom. Poly(vinyl chloride) liquid‐membrane ion‐selective electrodes were prepared with each of the four ionophores, and their response patterns to various alkali metals were determined. The results of this experimentation revealed that the coordinating ability of the sidearm is more important than the substitution at the geminal group at the pivot atom. It was also demonstrated that the change of a single atom in the sidearm structure, to induce coordinating ability to the sidearm, alters the selectivity between sodium and potassium by roughly five orders of magnitude