Overdiagnosis of mental disorders in children and adolescents (in developed countries)

During the past 50 years, health insurance providers and national registers of mental health regularly report significant increases in the number of mental disorder diagnoses in children and adolescents. However, epidemiological studies show mixed effects of time trends of prevalence of mental disorders. Overdiagnosis in clinical practice rather than an actual increase is assumed to be the cause for this situation. We conducted a systematic literature search on the topic of overdiagnosis of mental disorders in children and adolescents. Most reviewed studies suggest that misdiagnosis does occur; however, only one study was able to examine overdiagnosis in child and adolescent mental disorders from a methodological point-of-view. This study found significant evidence of overdiagnosis of attention-deficit/hyperactivity disorder. In the second part of this paper, we summarize findings concerning diagnostician, informant and child/adolescent characteristics, as well as factors concerning diagnostic criteria and the health care system that can lead to mistakes in the routine diagnostic process resulting in misdiagnoses. These include the use of heuristics instead of data-based decisions by diagnosticians, misleading information by caregivers, ambiguity in symptom description relating to classification systems, as well as constraints in most health systems to assign a diagnosis in order to approve and reimburse treatment. To avoid misdiagnosis, standardized procedures as well as continued education of diagnosticians working with children and adolescents suffering from a mental disorder are needed

Misclassification of self-directed violence

$\it Background:$ Classification of acts of self-directed violence has been shown to be inadequate in past research. Furthermore, level of expertise have been shown to be unrelated to classification correctness. $\it Aim:$ The aim of the present study was to investigate whether participants provided with a definition are more reliable in their judgment than participants without a definition. $\it Method:$ Two hundred sixty-one participants (psychology students, psychotherapists-in-training) were presented with case vignettes describing different acts of self-directed violence and were asked to make a classification. On the basis of randomized allocation, half of the participants received a definition of the different acts of self-directed violence, whereas the others did not. $\it Results:$ Overall, 24.9% of the cases were misclassified. The presentation of a definition was not accompanied by a higher classification accuracy. $\it Limitations:$ There may be issues about the validity of the case vignettes. $\it Conclusions:$ The results highlight the importance of more methodological training of psychologists regarding suicidal issues

An investigation of diagnostic accuracy and confidence associated with diagnostic checklists as well as gender biases in relation to mental disorders

This study examines the utility of checklists in attaining more accurate diagnoses in the context of diagnostic decision-making for mental disorders. The study also aimed to replicate results from a meta-analysis indicating that there is no association between patients’ gender and misdiagnoses. To this end, 475 psychotherapists were asked to judge three case vignettes describing patients with Major Depressive Disorder (MDD), Generalized Anxiety Disorder, and Borderline Personality Disorder. Therapists were randomly assigned to experimental conditions in a 2 (diagnostic method: with using diagnostic checklists vs. without using diagnostic checklists) x 2 (gender: male vs. female case vignettes) between-subjects design. Multinomial logistic and linear regression analyses were used to examine the association between the usage of diagnostic checklists as well as patients’ gender and diagnostic decisions. The results showed that when checklists were used, fewer incorrect co-morbid diagnoses were made, but clinicians were less likely to diagnose MDD even when the criteria were met. Additionally, checklists improved therapists’ confidence with diagnostic decisions, but were not associated with estimations of patients’ characteristics. As expected, there were no significant associations between gender and diagnostic decisions

Skala Suizidales Erleben und Verhalten (SSEV)

Suizidales Erleben und Verhalten ist in klinischen Kontexten sehr verbreitet. Während international diverse Messinstrumente zur Erfassung von Suizidalität entwickelt und validiert wurden, gibt es nur wenige deutsche Messinstrumente. In der vorliegenden Studie wurde die neu entwickelte Skala Suizidales Erleben und Verhalten (SSEV) in fünf Stichproben mit insgesamt $\it N$ = 1 099 Proband_innen im Hinblick auf ihre psychometrischen Eigenschaften untersucht. Die faktorenanalytische Untersuchung (explorative und konfirmatorische Faktorenanalyse) ergab eine eindimensionale Struktur des Fragebogens. Die interne Konsistenz der SSEV ist hoch und es zeigten sich erwartungsgemäß positive Zusammenhänge zu diversen Maßen aktueller Theoriemodelle suizidalen Erlebens und Verhaltens, sowie zu Depressivität, Angst und Stress. Weitere Analysen zeigten erwartungskonform negative Zusammenhänge mit sozialer Unterstützung und positiver mentaler Gesundheit. Insgesamt verweisen die Ergebnisse darauf, dass es sich beim SSEV um ein reliables und valides Instrument zur Erfassung von akutem suizidalem Erleben und Verhalten handelt, welches in der Forschung und der klinischen Praxis angewendet werden kann.Suicide ideation and suicide behavior occur commonly in clinical contexts. While various instruments for the assessment of suicidality have been developed and validated internationally, only few German instruments are presently available. The present study examines the psychometric properties of the newly developed Scale for Suicidal Experience and Behavior (SSEV) in five samples with $\it N$ = 1 099 subjects. Exploratory and confirmatory factor analysis revealed a one-dimensional structure of the scale. The internal consistency of the scale is high, and strong positive associations were found with various measures of current theoretical models of suicide as well as with depression, anxiety, and distress. Further analyses exhibited negative correlations with social support and positive mental health. Overall, the results indicate that the SSEV is a reliable and valid instrument for measuring acute suicidality and can be applied in research and clinical practice

Long-term effectiveness of cognitive behavioral therapy in routine outpatient care

$\bf {Objective:}$ Long-term follow-ups several years after receiving cognitive behavioral therapy (CBT) are scarce and most of the existing literature describes follow-up data of randomized-controlled trials. Thus, very little is known about the long-term effects of CBT in routine care. $\bf {Methods:}$ We investigated psychological functioning in a sample of 263 former outpatients who had received CBT for a variety of mental disorders such as depression, anxiety-, eating- or somatoform disorders 8.06 (SD 5.08) years after treatment termination. All participants completed a diagnostic interview as well as the Brief-Symptom Inventory (BSI) and the Beck Depression Inventory (BDI). Effect sizes and response rates according to Jacobson and Truax [J Consult Clin Psychol 1991;59:12–9] were calculated from pre- to posttreatment and from pretreatment to follow-up assessment. $\bf {Results:}$ Pre- to posttreatment effect sizes ranged between 0.75 (BDI) and 0.63 (BSI) and pretreatment to follow-up effect sizes were 0.92 (BDI) and 0.75 (BSI). Of all patients, 29% (BDI) and 17% (BSI) experienced clinically significant change at posttreatment and 42% (BDI) and 24% (BSI) at follow-up. $\bf {Conclusion:}$ The results point to the long-term effectiveness of CBT under routine conditions for a wide array of problems, especially when compared to the long-term effects of medical treatment. It is noteworthy that the results at follow-up were even better than at posttreatment, indicating further improvement. However, about a quarter of the patients did not respond sufficiently to therapy, neither concerning short-term nor long-term effects

Psychotherapists' knowledge of guideline recommendations for the treatment of depressed suicidal patients

$\bf Objective:$ Clinical practice guidelines present expert consensus on the treatment of mental disorders. Yet, studies have shown that knowledge of and adherence to recommendations are moderate. The aim of the present study was to investigate, whether and to what extent psychotherapists are aware of and follow the German guideline recommendations for the treatment of suicidal depressed patients. $\bf Methods:$ 174 participants (licensed psychotherapists, psychotherapists-in-training) were presented with five groups of guideline recommendations (referring to inpatient admission, psychotherapy, acute pharmacotherapy, pharmacologic relapse prevention, follow-up appointments) and were asked to identify the guideline recommendation and indicate whether they provided treatment according to the guideline. $\bf Results:$ Knowledge and adherence to the guidelines recommendations on psychotherapy and inpatient admission were well present. However, knowledge about pharmacological treatment recommendations was low; same as the knowledge on the necessity of immediate follow-up appointments after discharge of patients hospitalized due to suicidality. $\bf Discussion:$ The results highlight the importance of greater dissemination of various facts about the management of suicidal patients

Validation of the German capability for suicide questionnaire (GCSQ) in a high-risk sample of suicidal inpatients

$\bf Background$ The German Capability for Suicide Questionnaire (GCSQ) was developed to measure fearlessness of death and pain tolerance – two constructs central to the Interpersonal Theory of Suicide. Initial scale development, definition of the factor structure and confirmation of the two-dimensional factor structure was performed in samples suffering from relatively low levels of suicide ideation/behavior. The present study aimed to validate the German Capability for Suicide Questionnaire (GCSQ) in a high-risk sample of suicidal inpatients. $\bf Methods$ Factor structure, reliability and validity were investigated in a sample of inpatients ($\it {N}$ = 296; 53.0% female; age in years: (\it {M}\) = 36.81, (\it {SD}\) = 14.27) admitted to a hospital due to a recent suicide attempt or an acute suicidal crisis (in immediate need of inpatient treatment). To establish convergent validity, interview-based assessments of lifetime suicide attempts and non-suicidal self-injury as well as questionnaire-based assessments of painful and provocative events were used. Finally, stability of GCSQ-scores over a follow-up period of 12 months was assessed. $\bf Results$ Results indicated good psychometric properties, and provided additional evidence for construct validity and stability of the subscales over a one-year period, and demonstrated adequate fit of the data with respect to the original factor structure. $\bf Conclusions$ Results suggest that the GCSQ is a brief, reliable, and valid measure of capability for suicide that can be used in clinic assessment and research

Using cognitive bias modification-appraisal training to manipulate appraisals about the self and the world in analog trauma

$\bf Background$ Dysfunctional appraisals are a key mechanism in posttraumatic stress disorder (PTSD). Experimental manipulations of appraisals via Cognitive Bias Modification-Appraisal (CBM-App) training targeting cognitions related to the ‘self’ has shown to affect analog trauma symptoms. The present study aimed to conceptually replicate and extend previous findings by comparing a newly developed 'world' to the original 'self' training, and investigate the moderating role of locus of control (LOC) on intrusions. $\bf Methods$ Healthy participants ($\it N$ = 173) were exposed to distressing films as an analog trauma induction. Next, participants received positive or negative CBM-App, targeting either self- or world-relevant appraisals. Dysfunctional appraisals and LOC were assessed pre- and post-training. During the week after the laboratory session, participants recorded their intrusions and associated distress in a diary. One week later, trauma-relevant symptomatology was assessed. $\bf Results$ Positive compared to negative CBM-App induced training-congruent appraisals, independent of the trained cognition (self vs. world). However, there was no effect on analog trauma symptoms and LOC did not moderate the training’s effect. $\bf Conclusions$ Our results underline the validity of CBM-App as a method to experimentally manipulate appraisals. However, since we did not fully replicate previous findings further research on mechanisms associated with transfer effects is warranted

Does napping enhance the effects of Cognitive Bias Modification-Appraisal training?

Posttraumatic Stress Disorder (PTSD) is characterised by dysfunctional appraisals of the trauma and its consequences including one’s own symptoms. Experimental studies have shown that Cognitive Bias Modification-Appraisal (CBM-App) training can reduce dysfunctional interpretations and analog trauma symptoms. One important question is how to enhance the effects of CBM-App. Following work suggesting that sleep has beneficial effects on consolidation processes and can thus improve learning, the present study investigated whether a brief period of sleep (i.e., a nap) enhances the effects of CBM-App. All participants watched a stressful movie as an analogue trauma induction. After that, participants received either positive or negative CBM-App training. Within each training, half of the participants then had a 90-minute nap or watched a neutral movie. Results showed that the CBM training induced training-congruent appraisals. Sleep did not enhance this effect. Participants who slept, however, experienced fewer intrusive memories of the analogue trauma, but this effect was independent of the CBM condition. These results provide valuable information about the effects of sleep during a 90-minute nap period on encoding of analogue trauma and emotional learning in the context of appraisal, and highlight the importance of sleep as a focus for continued research

Brief reasons for living inventory

$\textbf {Background:}$ The present study aimed at validating the German version of the Brief Reasons for Living inventory (BRFL). $\textbf {Methods:}$ Validity and reliability were established in a community ($\it n$ = 339) and a clinical sample ($\it n$ = 272). Convergent and discriminant validity were investigated, and confirmatory factor analyses were conducted for the complete BRFL as well as for a 10-item version excluding conditional items on child-related concerns. Furthermore, it was assessed how BRFL scores moderate the association between depression and suicide ideation. $\textbf {Results:}$ Results indicated an adequate fit of the data to the original factor structure. The total scale and the subscales of the German version of the BRFL had sufficient internal consistency, as well as good convergent and divergent validity. The BRFL demonstrated clinical utility by differentiating between participants with vs. without suicide ideation. Reasons for living proved to moderate the association between depression and suicide ideation. $\textbf {Conclusions:}$ Results provide preliminary evidence that the BRFL may be a reliable and valid measure of adaptive reasons for living that can be used in clinic and research settings