Problematisation and regulation: bodies, risk, and recovery within the context of Neonatal Abstinence Syndrome

Background Neonatal Abstinence Syndrome (NAS) is an anticipated effect of maternal drug use during pregnancy. Yet it remains a contested area of policy and practice. In this paper, we contribute to ongoing debates about the way NAS is understood and responded to, through different treatment regimes, or logics of care. Our analysis examines the role of risk and recovery discourses, and the way in which the bodies of women and babies are conceptualised within these. Methods Qualitative interviews with 16 parents (9 mothers, 7 fathers) and four focus groups with 27 health and social care professionals based in Scotland. All the mothers were prescribed opioid replacement therapy and parents were interviewed after their baby was born. Data collection explored understandings about the causes and consequences of NAS and experiences of preparing for, and caring for, a baby with NAS. Data were analysed using a narrative and discursive approach. Results Parent and professional accounts simultaneously upheld and subverted logics of care which govern maternal drug use and the assessment and care of mother and baby. Despite acknowledging the unpredictability of NAS symptoms and the inability of the women who are opioid-dependent to prevent NAS, logics of care centred on ‘proving’ risk and recovery. Strategies appealed to the need for caution, intervening and control, and obscured alternative logics of care that focus on improving support for mother-infant dyads and the family as a whole. Conclusion Differing notions of risk and recovery that govern maternal drug use, child welfare and family life both compel and trouble all logics of care. The contentious nature of NAS reflects wider socio-political and moral agendas that ultimately have little to do with meeting the needs of mothers and babies. Fundamental changes in the principles, quality and delivery of care could improve outcomes for families affected by NAS

Can We Teach a Programming Language as a Second Language?

This paper describes a design and implementation of a NSF sponsored project in 2015. This study will test the hypothesis that the use of cognitive frameworks in second language acquisition for the development of a blended learning of programming languages can improve engagement and the learning experience of engineering students. Using this approach will place greater emphasis on problem solving techniques that can be utilized in all courses. The online module consists of a series of short videos (10-20 minutes), online quizzes with tiered questions, and topic specified discussion board led by student researchers. Students’ demographic data, course-related behaviors such as usage of the instructional videos and discussion board, student performance such as quizzes and exams, and attitude toward the class will be compared across students in the experimental groups, and control groups to determine if student performance, behavior and attitudes vary across classrooms employing different teaching strategies

A Second Language Acquisition Approach to Learning Programming Languages

The instructional design for modules in the study was based on the evidence that learning a programming language is analogous to students acquiring a second language, and utilized tools from Second Language Acquisition (SLA) theory. A programming language has vocabulary, syntax, grammar and communicative outcomes that must be sufficiently developed for the learner to function successfully in the environment that utilizes the language. This proposed study utilized an SLA approach to programming language in a blended learning environment. Modifications to the course pedagogy included breaking the course topics into video lessons focusing on basic programming vocabulary, grammar, and syntax. These videos had opportunities for the students to practice new commands and dynamically apply the grammatical programming rules introduced in the lesson. Student performance in sections using the SLA approach will be compared with that of students in unaltered programming sections using student survey responses, class participation and course grades

Implementation and Evaluation of a Second Language Acquisition-Based Programming Course

This paper describes initial findings of an NSF funded project under the Research Initiation Grant in Engineering Education (RIGEE) program. The RIGEE program is a multidisciplinary program focused on developing innovative, implementing and assessing innovative programs that enhance engineering education. The project applied theory and methods of second language acquisition (SLA) to teach an introductory programming course in engineering. The project is a two year long project implemented in multiple sections of an introductory programming class at a technological university, and assessed throughout implementation. It included a component whereby student assistants participated in project development and implementation, and were mentored by project leads. The current presentation presents the results of the fall 2015 assessment of learning effectiveness in the course, and compares SLA course sections to non- SLA sections. Objective and subjective measures of effectiveness were collected and analyzed

The value of source data verification in a cancer clinical trial

Background Source data verification (SDV) is a resource intensive method of quality assurance frequently used in clinical trials. There is no empirical evidence to suggest that SDV would impact on comparative treatment effect results from a clinical trial. Methods Data discrepancies and comparative treatment effects obtained following 100% SDV were compared to those based on data without SDV. Overall survival (OS) and Progression-free survival (PFS) were compared using Kaplan-Meier curves, log-rank tests and Cox models. Tumour response classifications and comparative treatment Odds Ratios (ORs) for the outcome objective response rate, and number of Serious Adverse Events (SAEs) were compared. OS estimates based on SDV data were compared against estimates obtained from centrally monitored data. Findings Data discrepancies were identified between different monitoring procedures for the majority of variables examined, with some variation in discrepancy rates. There were no systematic patterns to discrepancies and their impact was negligible on OS, the primary outcome of the trial (HR (95% CI): 1.18(0.99 to 1.41), p = 0.064 with 100% SDV; 1.18(0.99 to 1.42), p = 0.068 without SDV; 1.18(0.99 to 1.40), p = 0.073 with central monitoring). Results were similar for PFS. More extreme discrepancies were found for the subjective outcome overall objective response (OR (95% CI): 1.67(1.04 to 2.68), p = 0.03 with 100% SDV; 2.45(1.49 to 4.04), p = 0.0003 without any SDV) which was mostly due to differing CT scans. Interpretation Quality assurance methods used in clinical trials should be informed by empirical evidence. In this empirical comparison, SDV was expensive and identified random errors that made little impact on results and clinical conclusions of the trial. Central monitoring using an external data source was a more efficient approach for the primary outcome of OS. For the subjective outcome objective response, an independent blinded review committee and tracking system to monitor missing scan data could be more efficient than SDV

Aborto infeccioso equino por herpesvirus: análisis de un brote

Las pérdidas gestacionales ocasionadas por infecciones virales, bacterianas y fúngicas, tienen una alta prevalencia en la especie equina, traduciéndose en ocasiones en elevadas pérdidas económicas para los propietarios. Una de las principales causas de aborto equino es la rinoneumonía equina causada principalmente por herpesvirus equino 1 y ocasionalmente por herpesvirus equino 4. Este patógeno accede por vía hematógena al útero produciendo un aborto agudo sin signos clínicos previos y diseminándose rápidamente entre los animales. Es por ello que en este trabajo se va a analizar la gran importancia de esta enfermedad en la especie equina, complementado con la descripción de un brote clínico ocurrido en el Reino Unido donde se observaron 5 abortos en un grupo de 14 yeguas, que habían sido previamente vacunadas. Eran hembras receptoras de embriones y yeguas de cría de diferentes razas y aptitud deportiva que en el momento del brote tuvieron contacto con otros animales. La vacunación disminuyó la diseminación del virus y la probabilidad de aparición de otros focos, aunque no los eliminó, por lo que siempre debería ir acompañada de otras medidas preventivas y de control que refuercen la lucha contra esta enfermedad.<br /

Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells

Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion. Conditioned medium from Clone #3 (CM#3) strongly promoted invasion, while CM from Clone #8 (CM#8) inhibited invasion in vitro. 2D DIGE followed by MALDI-TOF MS analysis of CM#3 and CM#8 identified 41 proteins which were differentially regulated; 27 proteins were down-regulated and 14 proteins up-regulated in the invasion-promoting CM#3 when compared to CM#8. Western blotting analysis confirmed the down-regulated expression of gelsolin and the up-regulation of aldehyde dehydrogenase 1A1 in CM#3. Down-regulation of aldehyde dehydrogenase 1A1 in Clone #3 CM and gelsolin levels in Clone #8 CM by siRNA transfection revealed an important involvement of these proteins in promoting and inhibiting invasion in these pancreatic cancer cell lines

GaiaGaia white dwarfs within 40 pc II: the volume-limited northern hemisphere sample

We present an overview of the sample of northern hemisphere white dwarfs within 40 pc of the Sun detected from $Gaia$ Data Release 2 (DR2). We find that 521 sources are spectroscopically confirmed degenerate stars, 111 of which were first identified as white dwarf candidates from $Gaia$ DR2 and followed-up recently with the William Herschel Telescope and Gran Telescopio Canarias. Three additional white dwarf candidates remain spectroscopically unobserved and six unresolved binaries are known to include a white dwarf but were not in our initial selection of white dwarfs in the $Gaia$ DR2 Hertzsprung-Russell diagram (HRD). Atmospheric parameters are calculated from $Gaia$ and Pan-STARRS photometry for all objects in the sample, confirming most of the trends previously observed in the much smaller 20 pc sample. Local white dwarfs are overwhelmingly consistent with Galactic disc kinematics, with only four halo candidates. We find that DAZ white dwarfs are significantly less massive than the overall DA population ($\overline{M}_\mathrm{DAZ} = 0.59\,\mathrm{M}_\odot$, $\overline{M}_\mathrm{DA} = 0.66\,\mathrm{M}_\odot$). It may suggest that planet formation is less efficient at higher mass stars, producing more massive white dwarfs. We detect a sequence of crystallised white dwarfs in the mass range from $0.6\ \lesssim M/\mathrm{M}_\odot \lesssim\ 1.0\,$ and find that the vast majority of objects on the sequence have standard kinematic properties that correspond to the average of the sample, suggesting that their nature can be explained by crystallisation alone. We also detect 56 wide binaries including a white dwarf and 26 double degenerates.Comment: 20 pages, 14 figures. Accepted for publication in MNRAS. Online tables available at http://deneb.astro.warwick.ac.uk/phrgwr/40pcTables/index.htm

Cataclysmic Variables in the First Year of the Zwicky Transient Facility

Using selection criteria based on amplitude, time, and color, we have identified 329 objects as known or candidate cataclysmic variables (CVs) during the first year of testing and operation of the Zwicky Transient Facility. Of these, 90 are previously confirmed CVs, 218 are strong candidates based on the shape and color of their light curves obtained during 3–562 days of observation, and the remaining 21 are possible CVs but with too few data points to be listed as good candidates. Almost half of the strong candidates are within 10 deg of the galactic plane, in contrast to most other large surveys that have avoided crowded fields. The available Gaia parallaxes are consistent with sampling the low mass transfer CVs, as predicted by population models. Our follow-up spectra have confirmed Balmer/helium emission lines in 27 objects, with four showing high-excitation He ii emission, including candidates for an AM CVn, a polar, and an intermediate polar. Our results demonstrate that a complete survey of the Galactic plane is needed to accomplish an accurate determination of the number of CVs existing in the Milky Way