Influencing effect of minerals composition in natural granite rocks on surface roughness

The machining of natural rocks is gaining ground in art and architecture. However, the parameters influencing the design of surfaces with low surface roughness values are still the subject of research. In this study, we analysed the composition of granite specimens to examine their effect on surface roughness. 5 different granite samples were milled and then examined with XRD equipment. Minerals on the surface were analysed by light microscopy and scanning electron microscopy. Then the surface area of the minerals was measured with a 3D imaging system for surface roughness. Based on the obtained results, we examined the amount of constituents of each mineral and the value of the surface roughness of the minerals. The results showed that changes in certain mineral constituents affect the value of surface roughness during machining. By this, the expected surface roughness value of the rocks can be predicted based on the composition

From genomes to diaries: a 3-year prospective, real-life study of ragweed-specific sublingual immunotherapy

During the last decades, the prevalence of allergy has dramatically increased. Allergen-specific immunotherapy is the only currently available medical intervention that has the potential to affect the natural course of the disease, but there are still many questions and unmet needs hindering its widespread use to fulfill its treatment potential and maximize its benefits for the society. To provide a comprehensive phenome-wide overview in sublingual immunotherapy, using ragweed allergy as a target, we planned and carried out a longitudinal, prospective, observational, open-label study (DesensIT). In this paper we present challenges of using deep and comprehensive phenotypes embracing biological, clinical and patient-reported outcomes in allergen-specific immunotherapy and show how we designed the DesensIT project to optimize data collection, processing and evaluation