8 research outputs found

    Models and Methods for Merge-In-Transit Operations

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    We develop integer programming formulations and solution methods for addressing operational issues in merge-in-transit distribution systems. The models account for various complex problem features including the integration of inventory and transportation decisions, the dynamic and multimodal components of the application, and the non-convex piecewise linear structure of the cost functions. To accurately model the cost functions, we introduce disaggregation techniques that allow us to derive a hierarchy of linear programming relaxations. To solve these relaxations, we propose a cutting-plane procedure that combines constraint and variable generation with rounding and branch-and-bound heuristics. We demonstrate the effectiveness of this approach on a large set of test problems with instances with up to almost 500,000 integer variables derived from actual data from the computer industry. Key words : Merge-in-transit distribution systems, logistics, transportation, integer programming, disaggregation, cutting-plane method

    A Comparison of Mixed-Integer Programming Models for Non-Convex Piecewise Linear Cost Minimization Problems

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    We study a generic minimization problem with separable non-convex piecewise linear costs, showing that the linear programming (LP) relaxation of three textbook mixed integer programming formulations each approximates the cost function by its lower convex envelope. We also show a relationship between this result and classical Lagrangian duality theory

    Modeling and solving network flow problems with piecewise linear costs, with applications in supply chain management

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    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science; and, Massachusetts Institute of Technology, Sloan School of Management, 1999.Includes bibliographical references (p. 130-132).by Keely L. Croxton.Ph.D

    The Order Fulfillment Process

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    Variable Disaggregation in Network Flow Problems with Piecewise Linear Costs

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    A Comparison of Mixed-Integer Programming Models for Nonconvex Piecewise Linear Cost Minimization Problems

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    We study a generic minimization problem with separable nonconvex piecewise linear costs, showing that the linear programming (LP) relaxation of three textbook mixed-integer programming formulations each approximates the cost function by its lower convex envelope. We also show a relationship between this result and classical Lagrangian duality theory.Piecewise Linear, Integer Programming, Linear Relaxation, Lagrangian Relaxation

    Cellular Signaling Mechanisms for Muscarinic Acetylcholine Receptors

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