205 research outputs found

    Brain responses to biological motion predict treatment outcome in young children with autism

    Get PDF
    Autism spectrum disorders (ASDs) are common yet complex neurodevelopmental disorders, characterized by social, communication and behavioral deficits. Behavioral interventions have shown favorable results—however, the promise of precision medicine in ASD is hampered by a lack of sensitive, objective neurobiological markers (neurobiomarkers) to identify subgroups of young children likely to respond to specific treatments. Such neurobiomarkers are essential because early childhood provides a sensitive window of opportunity for intervention, while unsuccessful intervention is costly to children, families and society. In young children with ASD, we show that functional magnetic resonance imaging-based stratification neurobiomarkers accurately predict responses to an evidence-based behavioral treatment—pivotal response treatment. Neural predictors were identified in the pretreatment levels of activity in response to biological vs scrambled motion in the neural circuits that support social information processing (superior temporal sulcus, fusiform gyrus, amygdala, inferior parietal cortex and superior parietal lobule) and social motivation/reward (orbitofrontal cortex, insula, putamen, pallidum and ventral striatum). The predictive value of our findings for individual children with ASD was supported by a multivariate pattern analysis with cross validation. Predicting who will respond to a particular treatment for ASD, we believe the current findings mark the very first evidence of prediction/stratification biomarkers in young children with ASD. The implications of the findings are far reaching and should greatly accelerate progress toward more precise and effective treatments for core deficits in ASD

    Hand lay-up of complex geometries-prediction, capture and feedback

    Get PDF

    On Lagrangian Coherent Structures in Laparoscopy

    Full text link
    Laparoscopy is an electrosurgical medical operation often involving an application of high-frequency alternating current to remove undesired biological tissue from the insufflated abdomen accessible through inlet and outlets trocars. One of the main byproducts in this process are the gaseous particles, called surgical smoke, which is found hazardous for both the patient and the operating room staff. The elimination of this hazardous material is an area of active research in the medical community. Thus, understanding dynamics influenced by the underlying flow inside the abdomen is crucial. In this article, we propose a computational fluid dynamics model and analyse the velocity field in an insufflated abdomen shaped domain by identifying the Lagrangian Coherent Structures (LCS) that are responsible for the transportation, mixing and accumulation of the material particles in the flow. By calculating the mixing strength we show that the regions revealed by these material curves are dependent on the angle, positions and number of the outlets and inlets. Hence, a novel utility of LCS in medical surgery is presented that can detail the dynamics of surgical smoke informing better design of effective smoke removal technologies

    Results from the Atacama B-mode Search (ABS) Experiment

    Full text link
    The Atacama B-mode Search (ABS) is an experiment designed to measure cosmic microwave background (CMB) polarization at large angular scales (ℓ>40\ell>40). It operated from the ACT site at 5190~m elevation in northern Chile at 145 GHz with a net sensitivity (NEQ) of 41 μ\muKs\sqrt{\rm s}. It employed an ambient-temperature sapphire half-wave plate rotating at 2.55 Hz to modulate the incident polarization signal and reduce systematic effects. We report here on the analysis of data from a 2400 deg2^2 patch of sky centered at declination −42∘-42^\circ and right ascension 25∘25^\circ. We perform a blind analysis. After unblinding, we find agreement with the Planck TE and EE measurements on the same region of sky. We marginally detect polarized dust emission and give an upper limit on the tensor-to-scalar ratio of r<2.3r<2.3 (95% cl) with the equivalent of 100 on-sky days of observation. We also present a new measurement of the polarization of Tau A and introduce new methods associated with HWP-based observations.Comment: 38 pages, 11 figure
    • …
    corecore