Il lavoro femminile in Friuli Venezia Giulia. Rapporto 2017

Il volume, curato dalla Prof. Roberta Nunin nella sua veste di Consigliera di parit\ue0 della Regione autonoma Friuli Venezia Giulia, raccoglie una serie di saggi sul lavoro femminile nella Regione FVG, muovendo dall'analisi dei rapporti biennali presentati alla Consigliera dalle aziende con pi\uf9 di cento dipendenti ai sensi della normativa in materia di pari opportunit\ue0 di genere nei luoghi di lavoro

Il lavoro femminile in Friuli Venezia Giulia. Rapporto 2019

Il volume, partendo dai dati ricavabili dei rapporti presentati dalle imprese con pi\uf9 di cento dipendenti alla Consigliera regionale di Parit\ue0, analizza lo stato dell'occupazione femminile in Friuli Venezia Giulia

Knowledge management to compete in digital era: skills evolution of enterprise systems

National Industry 4.0 Plan is contributing to introduce new digital industrial technologies within the enterprise sector. This has brought the researchers and the experts of the sector to study as the business equilibriums are evolving and what new emergent professionalisms can be. On this basis, the paper aims to identify these skills and analyze professional’s dynamics, in order to achieve a higher level of competitiveness on the national manufacturing sector 4.0 stage. National Industry 4.0 Plan provides significant incentives aimed at strengthening R&D investments and incentivizing new technologies investments, as well as developing new skills among the professionals who will play a primary role in the "new 4.0 companies". Therefore, Industry 4.0 does not only intend to promote investments in new machinery and technologies, but, in parallel, to modify both, the productive and organizational paradigms, to effectively manage the indispensable and delicate process of cultural and organizational transformation. In other words, the goal is to transform all the processes into a continuous sequence of interconnected inter-digitally phases, which will be managed by an inter-functional group that has complete responsibility for it. This target is to be considered as a result of a training process across all company levels, which, according to a bottom up approach, stimulates a process of new skills creation and increases the sense of belonging to the company. This process also accompanying the profound changes of non-technological nature, which, however, are a presupposition and consequence of technology. In this perspective, the paper intends to set up a desk analysis - where the main focus are the national SMEs - aimed at better identifying the necessary skills to achieve a higher competitiveness level in the landscape 4.0 and, consequently, analysing the evolution of the professionalism that are characterizing the evolution of the enterprise systems

Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial

BackgroundTocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.MethodsA multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study the effect of tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints, a priori expected rates being 20 and 35%, respectively). A further prospective cohort of patients, consecutively enrolled after the first cohort was accomplished, was used as a secondary validation dataset. The two cohorts were evaluated jointly in an exploratory multivariable logistic regression model to assess prognostic variables on survival.ResultsIn the primary intention-to-treat (ITT) phase 2 population, 180/301 (59.8%) subjects received tocilizumab, and 67 deaths were observed overall. Lethality rates were equal to 18.4% (97.5% CI: 13.6-24.0, P=0.52) and 22.4% (97.5% CI: 17.2-28.3, P<0.001) at 14 and 30 days, respectively. Lethality rates were lower in the validation dataset, that included 920 patients. No signal of specific drug toxicity was reported. In the exploratory multivariable logistic regression analysis, older age and lower PaO2/FiO2 ratio negatively affected survival, while the concurrent use of steroids was associated with greater survival. A statistically significant interaction was found between tocilizumab and respiratory support, suggesting that tocilizumab might be more effective in patients not requiring mechanical respiratory support at baseline.ConclusionsTocilizumab reduced lethality rate at 30 days compared with null hypothesis, without significant toxicity. Possibly, this effect could be limited to patients not requiring mechanical respiratory support at baseline.Registration EudraCT (2020-001110-38); clinicaltrials.gov (NCT04317092)