161 research outputs found
The Origins of Concentric Demyelination: Self-Organization in the Human Brain
Baló's concentric sclerosis is a rare atypical form of multiple sclerosis characterized by striking concentric demyelination patterns. We propose a robust mathematical model for Baló's sclerosis, sharing common molecular and cellular mechanisms with multiple sclerosis. A reconsideration of the analogies between Baló's sclerosis and the Liesegang periodic precipitation phenomenon led us to propose a chemotactic cellular model for this disease. Rings of demyelination appear as a result of self-organization processes, and closely mimic Baló lesions. According to our results, homogeneous and concentric demyelinations may be two different macroscopic outcomes of a single fundamental immune disorder. Furthermore, in chemotactic models, cellular aggressivity appears to play a central role in pattern formation
Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis
Development of neurosurgery in Southern California and the Los Angeles County/University of Southern California Medical Center
A Case of Traumatic Brain Injury Developing Frontal Lobe Syndrome after a Long Incubation Period
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