Molar Incisor Hypomineralisation: Possible Aetiological Factors In Children From Urban And Rural Areas

Aim: To analyse factors potentially associated with molar incisor hypomineralisation (MIH) development. METHODS: A population-based study was carried out with 903 children aged from 6-12 years old, born and residing in rural and urban areas of the town of Botelhos, State of Minas Gerais, Brazil. Their mothers completed a structured medical history questionnaire, from pregnancy to the child's 3rd year of life. Two examiners evaluated children for MIH according to criteria suggested by the European Academy of Paediatric Dentistry. Descriptive analyses of the data and odds ratios (OR) with 95% test-based confidence intervals (CI) were estimated. Chisquare test was used to evaluate the differences between groups. RESULTS: The prevalence of MIH in children from rural area (RA) was significantly higher than those from the urban area (UA) (24.9% versus 17.8%, p= 0.01). In urban children, neither significant associations with MIH nor medical problems were found. In rural children, however, MIH was significantly more common among those whose mothers had experienced medical problems during pregnancy (OR=2.11; 1.01-4.37 CI 95%; p=0.04), who had throat infections (OR=2.93; 1.47-5.87 CI 95%; p=0.01), who had high fever (OR=1.91; 1.07-3.39 CI 95%; p=0.02), and who had used amoxicillin associated with other antibiotics (OR=1.92; 1.02-3.62 CI 95%; p=0.04) during the first 3 years of life. CONCLUSION: This study suggests a link between MIH and health problems during pregnancy, as well as environmental factors.134164170Aine, L., Backström, M.C., Mäki, R., Enamel defects in primary and permanent teeth of children born prematurely (2000) J Oral Pathol Med, 29, pp. 403-409Alaluusua, S., Lukinmaa, P., Vartiainen, T., Polychlorinated dibenzo-p-dioxins and di-benzofurans via mother's milk may cause development defects in the child's teeth (1996) Environ Toxicol Pharmacol, 15, pp. 193-197Alaluusua, S., Aetiology of molar-incisor hypomineralisation: a systematic review (2010) Eur Arch Paediatr Dent, 11, pp. 53-58Beentjes, V.E., Weerheijm, K.L., Groen, H.J., Factors involved in the aetiology of molar-incisor hypomineralisation (MIH) (2002) Eur J Paediatr Dent, 3, pp. 9-13Chowdhury, I.G., Bromage, T.G., Effects of fetal exposure to nicotine on dental development of the laboratory rat (2000) Anat Rec, 258, pp. 397-405Costa-Silva, C.M., Jeremias, F., Souza, J.F., Molar incisor Hypomineralisation: prevalence, severity and clinical consequences in Brazilian children (2010) Int J Paediatr Dent, 20, pp. 426-434Crombie, F., Manton, D., Kilpätrick, N., Aetiology of molar-incisor hypomineralisation: a critical (2009) Int J Paediatr Dent, 19, pp. 73-83Fagrell, T.G., Ludvigsson, J., Ullbro, C., Lundin, S.A., Koch, G., Aetiology of severe demarcated enamel opacities-an evaluation based on prospective medical and social data from 17 (2011) 000 children. Swed Dent J, 35, pp. 57-67Hong, L., Levy, S.M., Warren, J.J., Association of amoxicillin use during early childhood with development tooth enamel defects (2005) Arch Pediatr Adolesc Med, 159, pp. 943-948Jälevik, B., Norén, J.G., Enamel Hypomineralisation of permanent first molars: a morphological study and survey of possible aetiological factors (2000) Int J Paediatr Dent, 10, pp. 278-289Jälevik, B., Norén, J.G., Klingberg, G., Barregard, L., Etiologic factors influencing the prevalence of demarcated opacities in permanent first molars in a group of Swedish children (2001) Eur J Oral Sci, 109, pp. 230-234Jan, J., Sovcikova, E., Kocan, A., Wsolva, L., Trnovec, T., Development dental defects in children exposed to PCBs in eastern Slovakia (2007) Chemosphere, 67, pp. 350-354Johnsen, D., Kreji, C., Hack, M., Faranoff, A., Distribution of enamel defects and the association with respiratory distress in very low birthweight infants (1984) J Dent Res, 63, pp. 59-64Koch, G., Hallonsten, A.L., Ludvigsson, N., Epidemiologic study of idiopathic enamel Hypomineralisation in permanent teeth of Swedish children (1987) Community Dent Oral Epidemiol, 15, pp. 279-285Kuscu, O.O., Caglar, E., Sandalli, N., The prevalence and aetiology of Molar-Incisor Hypomineralisation in a group of children in Istanbul (2008) Eur J Paediatr Dent, 9, pp. 139-144Laisi, S., Ess, A., Sahlberg, C., Amoxicillin may cause molar incisor Hypomineralisation (2009) J Dent Res, 88, pp. 132-136Lygidakis, N.A., Dimou, G., Marinou, D., Molar incisor hypomineralisation (MIH) A retrospective clinical study in Greek children. II. Possible medical aetiological factors (2008) Eur Ach Paediatr Dent, 9, pp. 207-217Scarfone, R.J., Pond, K., Thompson, K., Fall, I., Utility of laboratory testing for infants with seizure (2000) Pediatr Emerg Care, 16, pp. 309-312Seow, W.K., Humphrys, C., Tudehope, D.I., Increased prevalence of developmental dental defects in low birth-weight, prematurely born children: a controlled study (1987) Pediatr Dent, 9, pp. 221-225Soviero, V., Haubek, D., Trindade, C., Da Matta, T., Poulsen, S., Prevalence and distribution of demarcated opacities and their sequelae in permanent 1st molars and incisors in 7 to 13-year-old Brazilian children (2009) Acta Odontol Scand, 67, pp. 170-175Suckling, G.W., Defects of enamel in sheep resulting from trauma during tooth development (1980) J Dent Res, 59, pp. 1541-1548Suga, S., Enamel Hypomineralisation viewed from pattern of progressive mineralization of human and monkey developing enamel (1989) Adv Dent Res, 3, pp. 188-198Tunk, K., Fujita, H., Yamashita, Y., Takagi, Y., Effect of turpentine-induced fever during the enamel formation of rat incisor (2006) Arch Oral Biol, 51, pp. 464-470van Amerongen, W.E., Kreulen, C.M., Cheese molars: a pilot study of the aetiology of hypocalcifications in the first permanent molars (1995) ASDC J Dent Child, 62, pp. 266-269Weerheijm, K.L., Jälevik, B., Alaluusua, S., Molar incisor Hypomineralisation (2001) Caries Res, 35, pp. 390-391Weerheijm, K.L., Duggal, M., Mejàre, I., Judgement criteria for Molar Incisor Hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens (2003) Eur J Paediatr Dent, 4, pp. 110-113Whatling, R., Fearne, J.M., Molar incisor Hypomineralisation: a study of aetiological factors in a group of UK children (2008) Int J Paediatr Dent, 18, pp. 155-162(1997) Oral Health Surveys Basic Methods, , World Health organization 4th edn Geneva: WH

Aetiology Of Molar-incisor Hypomineralisation (mih) In Brazilian Children

Aim: To determine the potential aetiological factors related to molar-incisor hypomineralisation (MIH) in Brazilian children. Methods: A total of 1,151 children aged 7-12 years (mean 8.86 ± 1.28), born and living in the urban area of Araraquara, Brazil, were examined by two examiners evaluating the presence of MIH according to criteria suggested by the European Academy of Paediatric Dentistry (2003). Their mothers completed a structured questionnaire about medical history, from pregnancy to the first 3 years of the children's life. Descriptive analyses of data and odds ratios (OR) with 95 % test-based confidence intervals (CI) were estimated. Chi-square test was used to evaluate the differences between groups. Results: The prevalence of MIH in the children was 12.3 %. The interviewing response rate was 90.4 %. The prevalence of miscarriage history (25 vs. 15.4 %; OR = 1.21; 95 % CI 0.30-4.92) and occurrence of anaemia (23 vs. 12.4 %; OR = 2.07; 95 % CI 0.50-8.63) were higher in mothers from MIH group than those from non-MIH group. However, these associations were not statically significant. In the children's medical history, rhinitis, bronchitis (56.5 vs. 52.5 %; OR = 1.17; 95 % CI 0.82-1.68), and high fever (20.4 vs. 18.2 %; OR = 1.14; 0.73-1.76) were more prevalent in MIH group, but there were no significant differences between the groups (p > 0.05). Conclusions: No possible aetiological factor investigated was associated with MIH. Prospective studies are needed to define the aetiological factors involved with MIH. © 2013 European Academy of Paediatric Dentistry.144233238Alaluusua, S., Lukinmaa, P., Vartiainen, T., Polychlorinated dibenzo-p-dioxins and dibenzofurans via mother's milk may cause development defects in the child's teeth (1996) Environ Toxicol Pharmacol, 1 (3), pp. 193-197Alaluusua, S., Aetiology of molar-incisor hypomineralisation: a systematic review (2010) Eur Arch Paediatr Dent, 11 (2), pp. 53-58Beentjes, V.E., Weerheijm, K.L., Groen, H.J., Factors involved in the aetiology of molar-incisor hypomineralisation (MIH) (2002) Eur J Paediatr Dent, 3 (1), pp. 9-13Costa-Silva, C.M., Jeremias, F., Souza, J.F., Molar incisor hypomineralisation: prevalence, severity and clinical consequences in Brazilian children (2010) Int J Paediatr Dent, 20 (6), pp. 426-434Crombie, F., Manton, D., Kilpatrick, N., Aetiology of molar incisor hypomineralisation: a critical review (2009) Int J Paediatr Dent, 19 (2), pp. 73-83Diedrich, G., Sperling, S., Hetzer, G., Molar incisor hypomineralisation in a group of children and adolescents living in Dresden (Germany) (2003) Eur J Paediatr Dent, 4 (3), pp. 133-137Fagrell, T.G., Ludvigsson, J., Ullbro, C., Lundin, S.A., Koch, G., Aetiology of severe demarcated enamel opacities-an evaluation based on prospective medical and social data from 17,000 children (2011) Swed Dent J, 35 (2), pp. 57-67Jälevik, B., Norén, J.G., Enamel hypomineralisation of permanent first molars: a morphological study and survey of possible aetiological factors (2000) Int J Paediatr Dent, 10 (4), pp. 278-289Jälevik, B., Norén, J.G., Klingberg, G., Barregard, L., Etiologic factors influencing the prevalence of demarcated opacities in permanent first molars in a group of Swedish children (2001) Eur J Oral Sci, 109 (4), pp. 230-234Jälevik, B., Klingberg, G., Barregard, L., Norén, J.G., The prevalence of demarcated opacities in permanent first molars in a group of Swedish children (2001) Acta Odontol Scand, 59 (5), pp. 255-260Jan, J., Vrbic, V., Polychlorinated biphenyls cause developmental enamel defects in children (2000) Caries Res, 34 (6), pp. 469-473Koch, G., Hallonsten, A.L., Ludvigsson, N., Epidemiologic study of idiopathic enamel hypomineralisation in permanent teeth of Swedish children (1987) Community Dent Oral Epidemiol, 15 (5), pp. 279-285Kuscu, O.O., Caglar, E., Sandalli, N., The prevalence and aetiology of molar-incisor hypomineralisation in a group of children in Istanbul (2008) Eur J Paed Dent, 9 (3), pp. 139-144Kuscu, O.O., Çaglar, E., Aslan, S., The prevalence of molar incisor hypomineralisation (MIH) in a group of children in a highly polluted urban region and a wind farm-green energy island (2009) Int J Paediatr Dent, 19 (3), pp. 176-185Laisi, S., Ess, A., Sahlberg, C., Amoxicillin may cause molar incisor hypomineralisation (2009) J Dent Res, 88 (2), pp. 132-136Leppaniemi, A., Lukinmaa, P.L., Alaluusua, S., Non fluoride hypomineralisations in the permanent first molars and their impact on the treatment need (2001) Caries Res, 35 (1), pp. 36-40Lygidakis, N.A., Dimou, G., Marinou, D., Molar incisor hypomineralisation (MIH). A retrospective clinical study in Greek children II. Possible medical aetiological factors (2008) Eur Ach Pediatr Dent, 9 (4), pp. 207-217Martinez, A., Cubillos, P., Jimenez, M., Prevalence of developmental enamel defects in mentally retarded children (2002) J Dent Child, 69 (2), pp. 151-155Paine, M.L., Zhu, D.H., Luo, W., Enamel biomineralization defects result from alterations to amelogenin self-assembly (2000) J Struct Biol, 132 (3), pp. 191-2000Seow, W.K., Enamel hypoplasia in the primary dentition: a review (1991) ASDC J Dent Child, 58 (6), pp. 441-452Seow, W.K., A study of the development of the permanent dentition in very low birth weight children (1996) Pediatr Dent, 18 (5), pp. 379-384Seow, W.K., Clinical diagnosis of enamel defects: pitfalls and practical guidelines (1997) Int Dent J, 47 (3), pp. 173-182Simmer, J.P., Hu, J.C., Expression, structure, and function of enamel proteinases (2002) Connect Tissue Res, 43 (2-3), pp. 441-449Suckling, G.W., Defects of enamel in sheep resulting from trauma during tooth development (1980) J Dent Res, 59 (9), pp. 1541-1548Tapias-Ledesma, M.A., Jimenez, R., Lamas, F., Factors associated with first molar dental enamel defects: a multivariate epidemiological approach (2003) J Dent Child, 70 (3), pp. 215-220van Amerongen, W.E., Kreulen, C.M., Cheese molars: a pilot study of the aetiology of hypocalcifications in the first permanent molars (1995) ASDC J Dent Child, 62 (4), pp. 266-269Weerheijm, K.L., Jälevik, B., Alaluusua, S., Molar incisor hypomineralisation (2001) Caries Res, 35 (5), pp. 390-391Weerheijm, K.L., Duggal, M., Mejàre, I., Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens (2003) Eur J Pediatr Dent, 4 (3), pp. 110-113Weerheijm, K.L., Molar incisor hypomineralisation (MIH): clinical presentation, aetiology and management (2004) Dent Update, 31 (1), pp. 9-12Whatling, R., Fearne, J.M., Molar incisor hypomineralisation: a study of aetiological factors in a group of UK children (2008) Int J Pediatr Dent, 18 (3), pp. 155-162(1997) Oral Health Surveys Basic Methods, , World Health Organisation4th edn., Geneva: WH

Family-based genetic association for molar-incisor hypomineralization

Despite some evidence of genetic and environmental factors on molar-incisor hypomineralization (MIH), its aetiology remains unclear. This family-based genetic association study aimed more comprehensively to investigate the genetic carriage potentially inv503310318FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO2011/13636-