Sistema embebido para el control de carga de baterías en un vehículo eléctrico híbrido ligero (EPISOL)

El presente trabajo es resultado de un proyecto para desarrollar un vehículo híbrido con varias fuentes de carga de baterías. Su objetivo es contribuir a reducir las emisiones debidas al tráfico urbano de vehículos, tendencia muy buscada en los últimos años, donde se han acometido importantes proyectos de investigación orientados al desarrollo de sistemas de propulsión y combustibles alternativos a los actualmente mayoritarios. A continuación se describe el sistema embebido de control realizado, en el que un microcontrolador se encarga del ajuste de la carga de las baterías, a partir de las contribuciones de una pila de combustible, unos paneles solares y un generador conectado a un motor de combustión interna, para conseguir el mayor rendimiento energético y lograr unos niveles de emisiones casi nulos

Diseño de mejoras electrónicas para vehículo de Fórmula SAE

Con el fin de mejorar la seguridad y los resultados del vehículo de Fórmula SAE del INSIA, se están implementando circuitos electrónicos que mejoren algunas prestaciones. Para ello se están realizando en la actualidad en la Escuela de Ingeniería Técnica de Telecomunicación diversos proyectos fin de carrera. Estos proyectos, que se ven reflejados en el presente artículo, cubren con un coste abordable las necesidades que van apareciendo en la evolución del vehículo de fórmula SAE

Definición de la gestión energética de un vehículo híbrido basada en la simulación del funcionamiento de los componentes del sistema propulsor en las condiciones de operación de diseño

La tendencia actual hacia el incremento de la movilidad en las sociedades más avanzadas va en contradicción con criterios de control de la contaminación local y la explotación de los recursos de combustible. Entre las soluciones planteadas, se encuentran los vehículos híbridos. En este artículo se presenta la definición y simulación de la gestión energética de uno de estos vehículos, a partir de las condiciones de operación. El vehículo híbrido diseñado en su totalidad combina propulsión con un motor eléctrico alimentado por baterías y un motor térmico, incluyéndose, además, paneles solares, así como carga externa por red eléctrica. Se han desarrollado modelos de simulación de los componentes y su integración. Analizando el campo de aplicación del vehículo, se ha planteado un ciclo de conducción a partir de ciclos estándar. Con el modelo, se ha analizado la idoneidad de diferentes estrategias de control de la energía, considerando diversas condiciones operativas

The rise and fall and rise again? Of associative processes in human contingency learning

Dickinson, Shanks, & Evenden claimed 30 years ago that associative processes may be underlying intuitive judgments in human contingency learning. However, this hypothesis has been seriously questioned by a more cognitive account based on inferential reasoning (see Shanks, 2010 for a review). A prediction derived from the associative hypothesis, probably not sufficiently tested, is that knowledge retrieval must be fast and derived from a spreading activation mechanism. Thus, associative processes may not only be underlying intuitive judgments but also individuals’ performance in tasks where a rapid response must be executed, after allowing little time to stimulus processing. Using a cued-response task as well as an associative repetition priming task, the experiments reported showed the implication of fast memory retrieval processes in interference and blocking phenomena. Additionally, the implications of these results for the associative-cognitive debate are discussed.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Pseudonimización y trazabilidad impersonal mediante códigos QR para la gestión de eventos UCM y gestión digital de certificados y diplomas

Desarrollo de una herramienta portátil, económica y viable, que de servicio más allá de tiempos de covid-19, para disponer de una trazabilidad rápida de las personas con un control respetuoso con los datos personales y escalar la solución a múltiples variantes (asignación de silla numerada, acceso de personas con movilidad reducida, etc.

Intermediate Molecular Phenotypes to Identify Genetic Markers of Anthracycline-Induced Cardiotoxicity Risk.

Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex trait with a polygenic component that is mainly unidentified. We propose that levels of intermediate molecular phenotypes (IMPs) in the myocardium associated with histopathological damage could explain CDA susceptibility, so variants of genes encoding these IMPs could identify patients susceptible to this complication. Thus, a genetically heterogeneous cohort of mice (n = 165) generated by backcrossing were treated with doxorubicin and docetaxel. We quantified heart fibrosis using an Ariol slide scanner and intramyocardial levels of IMPs using multiplex bead arrays and QPCR. We identified quantitative trait loci linked to IMPs (ipQTLs) and cdaQTLs via linkage analysis. In three cancer patient cohorts, CDA was quantified using echocardiography or Cardiac Magnetic Resonance. CDA behaves as a complex trait in the mouse cohort. IMP levels in the myocardium were associated with CDA. ipQTLs integrated into genetic models with cdaQTLs account for more CDA phenotypic variation than that explained by cda-QTLs alone. Allelic forms of genes encoding IMPs associated with CDA in mice, including AKT1, MAPK14, MAPK8, STAT3, CAS3, and TP53, are genetic determinants of CDA in patients. Two genetic risk scores for pediatric patients (n = 71) and women with breast cancer (n = 420) were generated using machine-learning Least Absolute Shrinkage and Selection Operator (LASSO) regression. Thus, IMPs associated with heart damage identify genetic markers of CDA risk, thereby allowing more personalized patient management.J.P.L.’s lab is sponsored by Grant PID2020-118527RB-I00 funded by MCIN/AEI/10.13039/ 501100011039; Grant PDC2021-121735-I00 funded by MCIN/AEI/10.13039/501100011039 and by the “European Union Next Generation EU/PRTR”, the Regional Government of Castile and León (CSI144P20). J.P.L. and P.L.S. are supported by the Carlos III Health Institute (PIE14/00066). AGN laboratory and human patients’ studies are supported by an ISCIII project grant (PI18/01242). The Human Genotyping unit is a member of CeGen, PRB3, and is supported by grant PT17/0019 of the PE I + D + i 2013–2016, funded by ISCIII and ERDF. SCLl is supported by MINECO/FEDER research grants (RTI2018-094130-B-100). CH was supported by the Department of Defense (DoD) BCRP, No. BC190820; and the National Cancer Institute (NCI) at the National Institutes of Health (NIH), No. R01CA184476. Lawrence Berkeley National Laboratory (LBNL) is a multi-program national laboratory operated by the University of California for the DOE under contract DE AC02-05CH11231. The Proteomics Unit belongs to ProteoRed, PRB3-ISCIII, supported by grant PT17/0019/0023 of the PE I + D +i, 2017–2020, funded by ISCIII and FEDER. RCC is funded by fellowships from the Spanish Regional Government of Castile and León. NGS is a recipient of an FPU fellowship (MINECO/FEDER). hiPSC-CM studies were funded in part by the “la Caixa” Banking Foundation under the project code HR18-00304 and a Severo Ochoa CNIC Intramural Project (Exp. 12-2016 IGP) to J.J.S

Cuentos del Olivar

En este apasionante viaje tenemos las puertas abiertas para todo aquel que se quiera sumar, ya sea trabajando en pos de la difusión de la cultura ligada al olivo o disfrutando de lecturas como las que se recogen en este libro, que seguro les depara un sabroso disfrute y les descubre una cultura del olivar que tiene a sus espaldas varios milenios de historia. Les deseo que paladeen cada uno de estos relatos, que conforman un excelente aperitivo literario.Área de Historia del Art

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Characterizing carbapenemase-producing Escherichia coli isolates from Spain: high genetic heterogeneity and wide geographical spread

IntroductionCarbapenemase-Producing Escherichia coli (CP-Eco) isolates, though less prevalent than other CP-Enterobacterales, have the capacity to rapidly disseminate antibiotic resistance genes (ARGs) and cause serious difficult-to-treat infections. The aim of this study is phenotypically and genotypically characterizing CP-Eco isolates collected from Spain to better understand their resistance mechanisms and population structure.MethodsNinety representative isolates received from 2015 to 2020 from 25 provinces and 59 hospitals Spanish hospitals were included. Antibiotic susceptibility was determined according to EUCAST guidelines and whole-genome sequencing was performed. Antibiotic resistance and virulence-associated genes, phylogeny and population structure, and carbapenemase genes-carrying plasmids were analyzed.Results and discussionThe 90 CP-Eco isolates were highly polyclonal, where the most prevalent was ST131, detected in 14 (15.6%) of the isolates. The carbapenemase genes detected were blaOXA-48 (45.6%), blaVIM-1 (23.3%), blaNDM-1 (7.8%), blaKPC-3 (6.7%), and blaNDM-5 (6.7%). Forty (44.4%) were resistant to 6 or more antibiotic groups and the most active antibiotics were colistin (98.9%), plazomicin (92.2%) and cefiderocol (92.2%). Four of the seven cefiderocol-resistant isolates belonged to ST167 and six harbored blaNDM. Five of the plazomicin-resistant isolates harbored rmt. IncL plasmids were the most frequent (45.7%) and eight of these harbored blaVIM-1. blaOXA-48 was found in IncF plasmids in eight isolates. Metallo-β-lactamases were more frequent in isolates with resistance to six or more antibiotic groups, with their genes often present on the same plasmid/integron. ST131 isolates were associated with sat and pap virulence genes. This study highlights the genetic versatility of CP-Eco and its potential to disseminate ARGs and cause community and nosocomial infections