15 research outputs found
Evaluation of ASAP-IM/MS(/MS) technique for the characterization of PEEK
International audienc
Fragmentation pathways of metopimazine and its metabolite using ESI-MS(n), HR-MS and H/D exchange.
International audienceMetopimazine (MPZ) is a phenothiazine derivative used to prevent emesis during chemotherapy where few structural analysis of the aforementioned compound have been described in the literature. Thus, this work reports, for the first time, the detailed study of fragmentation pathways of MPZ and its metabolite (AMPZ) using electrospray ionization (EI) with multistage mass spectrometry (ESI-MS(n)) in positive-ion mode. The structures of 21 product ions were identified and their accurate masses were determined using high resolution mass spectrometry (HRMS) experiments. Characteristic product ions of these two phenothiazine derivatives are more particularly displayed along with differences between their relative abundances and their structures checked by H/D exchange experiments
Evaluation of atmospheric solid analysis probe ionization coupled to ion mobility mass spectrometry for characterization of poly(ether ether ketone) polymers
International audienceRecently, the interest of the coupling between atmospheric solid analysis probe (ASAP) and ion mobilityâ mass spectrometry has been revealed in the field of polymers. This method associates a direct ionization technique with a bi-dimensional separation method. Poly(ether ether ketones) (PEEK) belong to the family of the poly(aryl ether ketones) (PAEK) which are high performance aromatic polymers usually used in aerospace, electronics and nuclear industries. PEEK are important commercial thermoplastics with excellent chemical resistance and good mechanical properties. Because of their low solubility, few structural characterization studies of PEEK have been reported. In mass spectrometry, only MALDI-TOF analyses for polymer synthesis monitoring have been described with the use of strong acids such as sulfuric acid. This work demonstrates that ASAP is particularly efficient for analysis of PEEK in a solvent free approach with the production of intact small oligomers (n 2). Five types of PEEK oligomers with different end-groups were evidenced. With MALDI-TOF, the same end-groups with almost the same relative abundance were obtained which support the hypothesis that the oligomers detected in ASAP are intact small oligomers and not fragments or pyrolysis products. This is particularly interesting as generally the ASAP analysis of polymers yields pyrolysis products with the loss of end-group information. The end-groups assignments have been confirmed by tandem mass spectrometry (MS/MS) experiments on the M+ molecular ions, which allowed highlighting some specific neutral or radical losses as well as two diagnostic product ions. Thus, ASAP-IM/MS/MS proves to be a fast and efficient alternative way to characterize low solubility polymers such as PEEK
Implementation of NMR and Mass Spectrometry experiments to analyse PEKK
International audienc
Characterization of poly(ether ketone ketone)s (PEKK)s using solution-state NMR and mass spectrometry
International audienc
Use of selective or quantitative NMR experiments for the characterization of poly(ether ketone ketone)s
International audienc
Characterization of poly(ether ketone ketone)s (PEKK)s using solution-state NMR and mass spectrometry
International audienc
Biomagnification of contaminants in a marine food web (NW Mediterranean Sea): speciation of arsenic and mercury toxic forms
International audienc