Evidence for Factorization in Three-body B --> D(*) K- K0 Decays

Motivated by recent experimental results, we use a factorization approach to study the three-body B --> D(*) K- K0 decay modes. Two mechanisms are proposed for kaon pair production: current-produced (from vacuum) and transition (from B meson). The Bbar0 --> D(*)+ K- K0 decay is governed solely by the current-produced mechanism. As the kaon pair can be produced only by the vector current, the matrix element can be extracted from e+ e- --> K Kbar processes via isospin relations. The decay rates obtained this way are in good agreement with experiment. Both current-produced and transition processes contribute to B- --> D(*)0 K- K0 decays. By using QCD counting rules and the measured B- --> D(*)0 K- K0 decay rates, the measured decay spectra can be understood.Comment: 17 pages, 6 figure

Charmless Two-body Baryonic B Decays

We study charmless two-body baryonic B decays in a diagramatic approach. Relations on decay amplitudes are obtained. In general there are more than one tree and more than one penguin amplitudes. The number of independent amplitudes can be reduced in the large m_B limit. It leads to more predictive results. Some prominent modes for experimental searches are pointed out.Comment: 15 pages, 2 figures. To appear in Phys. Rev.

Psychometric properties of the five-level EuroQoL-5 dimension and Short Form-6 dimension measures of health-related quality of life in a population of pregnant women with depression

BACKGROUND: Although evidence suggests that the EuroQoL-5 dimension (EQ-5D) and Short Form-6 dimension (SF-6D) have equivalent psychometric properties in people with depression, there is some evidence that the EQ-5D may lack responsiveness in certain populations with depression. AIMS: To examine the psychometric properties of the five-level EQ-5D (EQ-5D-5L) and SF-6D measures of health-related quality of life in a representative sample of pregnant women with depression. METHOD: Data were taken from a cohort of pregnant women identified at or soon after the first antenatal care contact and followed-up at 3 months postpartum. Health-related quality of life was measured using both the EQ-5D-5L and the SF-6D at baseline and follow-up. We examined acceptability and conducted psychometric validation in the aspects of concurrent validity, convergent validity, known-group validity and responsiveness in 421 women with available data. RESULTS: The EQ-5D-5L and SF-6D have similarly high levels of acceptability. However, concurrent validation shows a lack of concordance between the EQ-5D-5L and SF-6D. The EQ-5D-5L tends to be higher than the SF-6D in individuals with better health states. The SF-6D tends to be higher than EQ-5D-5L in individuals with poorer health states. Convergent and known-group validity are comparable between the two utility measures. Longitudinally, women who recovered show larger increase in SF-6D utilities than those who did not recover at follow-up. With the EQ-5D-5L, this is not the case. Additionally, the ceiling effects were more apparent in the EQ-5D-5L. CONCLUSIONS: The effectiveness of perinatal mental health interventions may be better captured by the SF-6D than the EQ-5D-5L but this needs to be cross-validated in more studies. DECLARATION OF INTEREST: L.M.H. chaired the National Institute for Health and Care Excellence CG192 guidelines development group on antenatal and postnatal mental health in 2012-2014. L.M.H. reports grants from NIHR, MRC, Nuffield and the Stefanou Foundation, UK. K.T., M.H. and S.B. report funding by NIHR and the Stefanou Foundation, UK

Structural Characterization of Rapid Thermal Oxidized Si\u3csub\u3e1−x−y\u3c/sub\u3eGe\u3csub\u3ex\u3c/sub\u3eC\u3csub\u3ey\u3c/sub\u3e Alloy Films Grown by Rapid Thermal Chemical Vapor Deposition

The structural properties of as-grown and rapid thermal oxidized Si1−x−yGexCy epitaxial layers have been examined using a combination of infrared, x-ray photoelectron, x-ray diffraction, secondary ion mass spectroscopy, and Raman spectroscopy techniques. Carbon incorporation into the Si1−x−yGexCy system can lead to compressive or tensile strain in the film. The structural properties of the oxidized Si1−x−yGexCy film depend on the type of strain (i.e., carbon concentration) of the as-prepared film. For compressive or fully compensated films, the oxidation process drastically reduces the carbon content so that the oxidized films closely resemble to Si1−xGex films. For tensile films, two broad regions, one with carbon content higher and the other lower than that required for full strain compensation, coexist in the oxidized films

THE IN VITRO AND EX VIVO EFFECT OF PHYLLANTHUS NIRURI METHANOL EXTRACT ON HEPATIC UDP-GLUCURONYLTRANSFERASE ENZYME ACTIVITY IN STZ-INDUCED DIABETIC SPRAGUE DAWLEY RATS

Objective: The aim of the study was to investigate the in vitro and ex vivo (acute and sub-chronic doses) effect of Phyllanthus niruri methanol extract (PNME) on the microsomal UDP-glucuronyltransferase (UGT) enzyme activity in streptozotocin (STZ)-induced diabetic young female Sprague Dawley (SD) rats. Methods: Young female SD rats were induced type I diabetes mellitus using STZ (60 mg/kg i. v.). The in vitro study was performed on a microsomal fraction of diabetic rat livers using PNME in doses of (0.01 µg, 1 µg and 10 µg)/ml. While ex vivo studies were performed on the microsomal fraction of diabetic rats using PNME in doses of 500, 1000, 2000 and 5000 mg/kg p. o. for acute ex vivo study (one-day treatment) and 100, 500 and 2000 mg/kg/day p. o. for sub-chronic one (daily dose for two weeks). p-nitrophenol (p-NP), was used as a marker substrate for UGT enzyme activity and analyzed using the spectrophotometer to determine UGT enzyme activity. Results: The in vitro result showed that, there is no significant effect of the three concentrations of PNME versus control on UGT activity in the microsomal fraction of diabetic young female SD rat livers, while for ex vivo study, the result showed that UGT activity in the microsomal fraction of diabetic young female SD rats significantly and dose-independently increased at doses 1000, 2000 and 5000 mg/kg p. o in acute study (all p<0.05 vs control). However, no significant effect of PNME has been seen in the three doses used in the sub-chronic study. Conclusion: The three different concentrations of PNME have no significant effect as compared to control on UGT activity in the in vitro study. However, ex vivo study showed significant and dose-independent increased in UGT activity at doses 1000, 2000, and 5000 mg/kg p. o in acute study (all P<0.01 vs control), but no significant effect on sub-chronic study

Limb bone scaling in hopping diprotodonts and quadrupedal artiodactyls

Bone adaptation is modulated by the timing, direction, rate, and magnitude of mechanical loads. To investigate whether frequent slow, or infrequent fast, gaits could dominate bone adaptation to load, we compared scaling of the limb bones from two mammalian herbivore clades that use radically different high-speed gaits, bipedal hopping and quadrupedal galloping. Forelimb and hindlimb bones were collected from 20 artiodactyl and 15 diprotodont species (body mass M 1.05 - 1536 kg) and scanned in clinical computed tomography or X-ray microtomography. Second moment of area (Imax) and bone length (l) were measured. Scaling relations (y = axb) were calculated for l vs M for each bone and for Imax vs M and Imax vs l for every 5% of length. Imax vs M scaling relationships were broadly similar between clades despite the diprotodont forelimb being nearly unloaded, and the hindlimb highly loaded, during bipedal hopping. Imax vs l and l vs M scaling were related to locomotor and behavioural specialisations. Low-intensity loads may be sufficient to maintain bone mass across a wide range of species. Occasional high-intensity gaits might not break through the load sensitivity saturation engendered by frequent low-intensity gaits

A new neurosurgical tool incorporating differential geometry and cellular automata techniques

Using optical coherence imaging, it is possible to visualize seizure progression intraoperatively. However, it is difficult to pinpoint an exact epileptic focus. This is crucial in attempts to minimize the amount of resection necessary during surgical therapeutic interventions for epilepsy and is typically done approximately from visual inspection of optical coherence imaging stills. In this paper, we create an algorithm with the potential to pinpoint the source of a seizure from an optical coherence imaging still. To accomplish this, a grid is overlaid on optical coherence imaging stills. This then serves as a grid for a two-dimensional cellular automation. Each cell is associated with a Riemannian curvature tensor representing the curvature of the brain's surface in all directions for a cell. Cells which overlay portions of the image which show neurons that are firing are considered "depolarized"

Further investigation on chaos of real digital filters

This Letter displays, via the numerical simulation of a real digital filter, that a finite-state machine may behave in a near-chaotic way even when its corresponding infinite-state machine does not exhibit chaotic behavior