100 research outputs found

    Clientelism as civil society? Unpacking the relationship between clientelism and democracy at the local level in South Africa

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    This article, building on analyses from the global south, attempts to reframe democratic expectations by considering where previously maligned practices such as clientelism may hold moments of democracy. It does so by comparing the theory of civil society with that of clientelism, and its African counterpart neo-patrimonialism. It argues that clientelism as civil society may fulfil democratic tasks such as holding the (local) state accountable, strengthening civil and political liberties and providing channels of access for previously marginalised groups. Clientelism is not necessarily a reflection of imposed power relations but, at times, can demonstrate a conscious political strategy, to generate development, on the part of its protagonists.IS

    The vampire squid: Value, crisis and the power of finance

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    Over the last five decades the power and global reach of financial institutions and finance capital to organize economic, social and political life has grown seemingly unchecked. This is manifested in the ability of international markets to limit the economic sovereignty of states; the power of activist shareholders to dictate policy to company management, often at the expense of long‐term strategy and employment creation; and the advantages offered by returns to investments in financial assets over those in manufacturing and services. All of these developments have contributed to the apparently inescapable triumph of neoliberalism and the deepening of global inequality. They have also led to the economic havoc of the 2008 financial crisis, which plunged the global economy into a period of austerity from which it has not yet emerged (Thompson, 2017). It is no wonder, then, that money markets and financial institutions have fallen from being the vaunted legislators of the world to become, for some, its new pariahs. A new consensus is emerging that many of our economic ills stem from the fact that banks and financiers, instead of merely facilitating the production of ‘real’ wealth in the form of services and goods, have slipped their bonds to become independent players in their own right. They are now seen at best as the tail wagging the dog and at worst as outright parasites: ‘a great vampire squid’, as one journalist described Goldman Sachs, ‘wrapped around the face of humanity, relentlessly jamming its blood funnel into anything that smells like money’ (Taibbi, 2010)

    Role of nucleus accumbens core but not shell in incubation of methamphetamine craving after voluntary abstinence

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    We recently introduced an animal model to study incubation of drug craving after prolonged voluntary abstinence, mimicking the human condition of relapse after successful contingency management treatment. Here we studied the role of the nucleus accumbens (NAc) in this model. We trained rats to self-administer a palatable solution (sucrose+maltodextrin 1%, 6 h/day, 6 days) and methamphetamine (6 h/day, 12 days). We then evaluated relapse to methamphetamine seeking after 1 and 15 days of voluntary abstinence, achieved via a discrete choice procedure between the palatable solution and methamphetamine (14 days). We used RNAscope in-situ hybridization to quantify the co-labeling of the neuronal activity marker Fos, and dopamine Drd1- and Drd2-expressing medium spiny neurons (MSNs) in NAc core and shell during the incubation tests. Next, we determined the effect of pharmacological inactivation of NAc core and shell by either GABAA and GABAB agonists (muscimol+baclofen, 50+50 ng/side), Drd1-Drd2 antagonist (flupenthixol, 10 ”g/side) or the selective Drd1 or Drd2 antagonists (SCH39166 1.0 ”g/side or raclopride 1.0 ”g/side) during the relapse tests. Incubated methamphetamine seeking after voluntary abstinence was associated with a selective increase of Fos expression in the NAc core, but not shell, and Fos was co-labeled with both Drd1- and Drd2-MSNs. NAc core, but not shell, injections of muscimol+baclofen, flupenthixol, SCH39166, and raclopride reduced methamphetamine seeking after 15 days of abstinence. Together, our results suggest that dopamine transmission through Drd1 and Drd2 in NAc core is critical to the incubation of methamphetamine craving after voluntary abstinence
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