18 research outputs found
Features of psychoemotional disorders in patients with multiple sclerosis in different clinical and demographic groups
Purpose: to conduct an analysis of psychoemotional disorders in patients with multiple sclerosis, who are not receiving any treatment for these disorders. Material and Methods. A cohort of patients with a reliable diagnosis of multiple sclerosis, according to the criteria of Π‘ Poseur, consisting of 163 people, was selected for the research. A four-dimensional symptomatic questionnaire was used to assess distress, depression, anxiety and somatization (4DSQ) and a self-questionnaire for evaluating the symptoms of fibromyalgia with quantitative measures (WPI, SS, FS). Re-sults. Differences in the average values of the level of distress, depression, anxiety and somatization in patients with multiple sclerosis of different sex, age, with different type of course and duration of the disease are shown. Conclusion. The neuropsychological status of patients depends on the type of course of the disease, the level of distress β from age and sex, the level of somatization βfrom the age of this category of patients. In the complex treatment of this category of patients it is necessary to use symptomatic treatment in addition to pathogenetic therapy, which has not only neurotrophic and vasoactive effects, but also affects the psychoemotional background of patients.</p
Bolshaya Elista 1 temporary camp - theory and practice of studying the settlement of ancient herders in the desert-steppe area
Soil biochemical inticators of initial presence of fat in different archaeological contexts
The article proposes a new biochemical approach for the reconstruction of the initial presence of fatcontaining products in different archaeological contexts (ceramic vessels from burials, soil samples in different parts of the skeleton and cultural layers of archaeological sites) based on the study of qualitative and quantitative changes in the parameters of the soil microbial community, namely, specific groups of microorganisms (lipolytics), a number of lipolytic enzymes, as well as the utilization spectrum of readily available low molecular weight substrates. Ground samples of the studied objects were collected in the following regions: ceramic vessels β the Republic of North Ossetia-Alania and the Chechen Republic; burials β Krasnodar Krai; the cultural layer of the settlement β Lipetsk region. The number of lipolytic microorganisms and the level of enzymatic activity in the soil directly depend on the amount of the incoming substrate, in the decomposition of which they participate. After the decomposition of organic residues in the soil, a microbial and enzyme pools are formed, which can persist for a long period. The obtained preliminary data on the study of the decomposition dynamics of fatty substrates give us possibility for the reconstruction of the initial presence of fat in different archaeological contexts using the methods of soil microbiology and biochemistry. But, for a more accurate extrapolation of the results of a model experiment to archaeological objects, more points of observation in time are needed, since the introduction of substrates with different properties and composition can provoke microbial community succession in different ways. Hence, the equilibrium state of the microbial community in each variant of the experiment will be reached at different times. However, the results of the study of soils and cultural layers of archaeological sites of Bronze Age and early medieval time have convincingly shown the possibility of applying our approach. As we assumed, the maximum lipase activity was found in the soil samples under the skull, chest and pelvis, i.e. in areas of human body with the highest content of fat tissues. This showed the possibility for reconstruction the original contents of the vessels from burials using the methods of soil microbiology and biochemistry. A high number of lipolytic microorganisms and lipase activity were detected only in 15β20 % of the vessels. We suggest that fat food may not have been as widely used in the funeral rite as ritual food. The study of lipase activity made it possible to clarify the features of the economic usage of the territory of archaeological site, to identify possible places for cooking
Features of catecholamines distribution in dogβs hearts with experimentally created different kinds of myocardium hyperfunction and their role in the development of congestive heart failure and arrhythmias
ΠΠ΅Π±ΡΡ Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ·Π° ΠΈΠ· ΠΊΠ»Π΅ΡΠΎΠΊ ΠΠ°Π½Π³Π΅ΡΠ³Π°Π½ΡΠ° Π²ΠΎ Π²Π·ΡΠΎΡΠ»ΠΎΠΌ Π²ΠΎΠ·ΡΠ°ΡΡΠ΅. ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅
Langerhans cell histiocytosis is mainly diagnosed in children, and its manifestation in adult age is quite uncommon. Skin rashes may be non-specific and mimic a number of dermatoses. Therefore, the clinical diagnosis is challenging and as a rule, such patients are misinterpreted and managed for other disorders by a dermatologist for some years.
We present a clinical case of Langerhans cell histiocytosis with skin involvement in a 35-year female patient, who had been treated by a dermatologist for 2 years for pyoderma, seborrheic dermatitis, and skin fold candidiasis. Taking into account the clinical signs and symptoms and age of manifestation, we initially suspected familial benign pemphigus (Hailey-Hailey disease) or follicular dyskeratosis (Darier's disease). However, the histological assessment showed Langerhans cell histiocytosis confirmed by immunohistochemistry with anti-langerin, anti-CD1a, and anti-protein S-100 antibodies. The patient was referred to a hematologist for further work-upand specific treatment.
In cases of any treatment resistant disorders, which do not respond to long-term conventional treatment, it is necessary to reconsider the diagnosis by means of histological investigation. It would allow for identification of a disease, which is uncommon in dermatology practice.ΠΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ· ΠΈΠ· ΠΊΠ»Π΅ΡΠΎΠΊ ΠΠ°Π½Π³Π΅ΡΠ³Π°Π½ΡΠ° Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΡΠ΅ΡΡΡ Ρ Π΄Π΅ΡΠ΅ΠΉ, Π΅Π³ΠΎ ΠΌΠ°Π½ΠΈΡΠ΅ΡΡΠ°ΡΠΈΡ Π²ΠΎ Π²Π·ΡΠΎΡΠ»ΠΎΠΌ Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ Π²ΡΡΡΠ΅ΡΠ°Π΅ΡΡΡ Π΄ΠΎΠ²ΠΎΠ»ΡΠ½ΠΎ ΡΠ΅Π΄ΠΊΠΎ. ΠΡΡΡΠΏΠ°Π½ΠΈΡ Π½Π° ΠΊΠΎΠΆΠ΅ ΠΌΠΎΠ³ΡΡ Π½ΠΎΡΠΈΡΡ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΈ ΠΈΠΌΠΈΡΠΈΡΠΎΠ²Π°ΡΡ ΡΡΠ΄ Π΄Π΅ΡΠΌΠ°ΡΠΎΠ·ΠΎΠ². ΠΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΡΡΠΎΠ³ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠ°Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ° Π·Π°ΡΡΡΠ΄Π½ΠΈΡΠ΅Π»ΡΠ½Π°, ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ, ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΡ
Π»Π΅Ρ ΠΎΡΠΈΠ±ΠΎΡΠ½ΠΎ Π½Π°Π±Π»ΡΠ΄Π°ΡΡΡΡ Ρ Π΄Π΅ΡΠΌΠ°ΡΠΎΠ»ΠΎΠ³Π° Ρ ΡΠ°Π·Π½ΡΠΌΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π°ΠΌΠΈ.
Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡΡΡ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ·Π° ΠΈΠ· ΠΊΠ»Π΅ΡΠΎΠΊ ΠΠ°Π½Π³Π΅ΡΠ³Π°Π½ΡΠ° Ρ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠΆΠΈ Ρ ΠΆΠ΅Π½ΡΠΈΠ½Ρ 35 Π»Π΅Ρ, ΠΊΠΎΡΠΎΡΠ°Ρ 2 Π³ΠΎΠ΄Π° Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ Ρ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π°ΠΌΠΈ ΠΏΠΈΠΎΠ΄Π΅ΡΠΌΠΈΠΈ, ΡΠ΅Π±ΠΎΡΠ΅ΠΉΠ½ΠΎΠ³ΠΎ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠ°, ΠΊΠ°Π½Π΄ΠΈΠ΄ΠΎΠ·Π° ΡΠΊΠ»Π°Π΄ΠΎΠΊ. Π£ΡΠΈΡΡΠ²Π°Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΠΊΠ°ΡΡΠΈΠ½Ρ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈ Π²ΠΎΠ·ΡΠ°ΡΡ Π½Π°ΡΠ°Π»Π° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π°Π²ΡΠΎΡΡ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΠ»ΠΈ Π½Π°Π»ΠΈΡΠΈΠ΅ ΡΠ΅ΠΌΠ΅ΠΉΠ½ΠΎΠΉ Π΄ΠΎΠ±ΡΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΏΡΠ·ΡΡΡΠ°ΡΠΊΠΈ Π₯Π΅ΠΉΠ»ΠΈ Π₯Π΅ΠΉΠ»ΠΈ Π»ΠΈΠ±ΠΎ ΡΠΎΠ»Π»ΠΈΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΡΠΊΠ΅ΡΠ°ΡΠΎΠ·Π° ΠΠ°ΡΡΠ΅. ΠΠ΄Π½Π°ΠΊΠΎ ΠΏΡΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ·Π° ΠΈΠ· ΠΊΠ»Π΅ΡΠΎΠΊ ΠΠ°Π½Π³Π΅ΡΠ³Π°Π½ΡΠ°, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΈΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Ρ Π°Π½ΡΠΈΡΠ΅Π»Π°ΠΌΠΈ ΠΊ Π»Π°Π½Π³Π΅ΡΠΈΠ½Ρ, CD1a, ΠΏΡΠΎΡΠ΅ΠΈΠ½Ρ S-100. ΠΠ»Ρ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π±ΠΎΠ»ΡΠ½Π°Ρ Π±ΡΠ»Π° Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π° ΠΊ Π³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³Ρ.
ΠΡΠΈ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
, Π½Π΅ ΠΎΡΠ²Π΅ΡΠ°ΡΡΠΈΡ
Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ Π½Π° ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ, Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ Π΄Π»Ρ ΡΡΠΎΡΠ½Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠ΅Π΅ Π²ΡΡΠ²Π»ΡΡΡ ΡΠ΅Π΄ΠΊΠΎ Π²ΡΡΡΠ΅ΡΠ°ΡΡΠΈΠ΅ΡΡ Π² ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ Π΄Π΅ΡΠΌΠ°ΡΠΎΠ»ΠΎΠ³Π° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ
Detailed Study of the Angular Correlations in the Prompt Neutron Emission in Spontaneous Fission of 252Cf
An experiment has been performed at IPHC Strasbourg, aimed at the detailed investigation of angular correlations in the neutron emission from spontaneous fission of 252Cf. Fission fragments were measured by the angle-sensitive double ionization chamber CODIS while neutrons were detected by a set of 60 DEMON scintillator counters. The main aim of the experiment is the observation of the correlation between the fragment spins and neutron emission anisotropy. Preliminary results, based on the Monte-Carlo simulations, as well as the preliminary analysis of the experimental data are shown.SCOPUS: cp.pinfo:eu-repo/semantics/publishe
Neutron emission anisotropy in fission
Experimental neutron angular distributions are investigated in the spontaneous fission process of 252Cf. The CORA experiment, presented in this paper, has the aim to study neutron angular correlations in order to elucidate the neutron emission mechanisms in the fission process. The experimental setup is composed by the CODIS fission chamber and the DEMON neutron multidetector. The development of a simulation toolkit based on GEANT4 and ROOT adopted as strategy to investigate the emission of the neutrons is described. Preliminary results on the sources of the anisotropy, scission neutron emission and/or dynamical anisotropy, are shown.SCOPUS: cp.jinfo:eu-repo/semantics/publishe