94 research outputs found
Isopropyl(ene)-type Cembrane Diterpene an Important Chemotaxonomical Marker in Bornean Soft Coral Genus Sarcophyton
Two cembrane diterpenoids; (+)-11,12-epoxysarcophytol A (1) and sarcophytol W
(2) were isolated from Sarcophyton sp. collected from Mantanani Island, Sabah.
Secondary metabolites structures were elucidated based on spectroscopic data.
This is the first record of cembranoid diterpenes isolated from the Bornean soft
coral genus Sarcophyton. The isopropyl(ene)-type cembrane derivatives could be
suggested as chemotaxonomical markers for soft coral genus Sarcophyton
The Chemotaxonomic Identification Using Structure Types of Secondary Metabolites and Their Bioactivities of Bornean Litophyton arboretum
The structure types and bioactivities of secondary metabolites derived from Litophyton arboreum, distributed in Sepanggar Bay, Sabah, Malaysia, were investigated as additional tools for establishing their species identification. As a result, a total of two secondary metabolites (alismol (1) and 10ι-methoxy-4βhydroxy guaian-6-ene (2)) were isolated from Bornean soft coral L. arboreum. Their structures were elucidated based on spectroscopic data analysis and the antifungal activities of compounds 1 and 2 were determined. In addition, the compound 2 showed highest antifungal activity against Haliphthoros milfordensis. As a result of comparison with previous literature, significant variations were observed in relation to structure types of secondary metabolites and bioactivities. Information from this study gives additional evidence of chemotaxonomic significance and baseline data for effective selection of suitable lead pharmaceuticals
Nangallenes A and B, halogenated nonterpenoid C15-acetogenins from the Bornean red alga Laurencia nangii
Two new halogenated nonterpenoids C15-acetogenins, nangallenes A-B (1â2), together with two known halogenated compounds itomanallene A (3) and 2,10-dibromo -3-chloro-Îą- chamigrene (4), were isolated and identified from the organic extract of the marine red alga Laurencia nangii Masuda collected from the coastal waters in Semporna, Borneo. Their structures were established by means of spectroscopic analysis including IR, high-resolution electrospray ionization mass spectrometry (HRESI-MS), and 1D and 2D NMR techniques. All these metabolites were submitted for the antifungal assay against four species of selected marine fungi. Compounds 1â4 showed potent activity against Haliphthoros sabahensis and Lagenidium thermophilum
Neoiriepentaol and nangenyne, halogenated diterpenoid and C15-acetogenin from red alga Laurencia nangii Masuda collected in Borneo [2018]
The red algal genus Laurencia is a prolific producer of halogenated secondary metabolites. A new tricyclic dibrominated diterpenoid, neoiriepentaol (1) and chlorinated Cââ
-acetogenin, nangenyne (2), along with two known terpenoids, neoirietetraol (3) and dactyloxene A (4), were isolated from methanol crude extract of red alga Laurencia nangii. The structures were established based on one- and two-dimensional nuclear magnetic resonance (NMR), Fourier-transform infrared (FTIR), and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. These compounds were screened against seven species of marine fungi. Compounds 1â3 exhibited activity against Lagenidium thermophilum and Haliphthoros sabahensis. Potent activity was showed by 1 with L. thermophilum hyphal inhibition at MIC value of 12.5 Οg mLâťÂš and hyphal motility was observed at 50 Οg mLâťÂš within 24 h
Capgermacrene C, a New Sesquiterpenoid from a Bornean Soft Coral, Capnella sp.
A new bicyclogermacrene, capgermacrene C (1), along with a known compound, 1,4-peroxy-5-muurolene (2), were isolated from a population of Bornean soft coral Capnella sp. The structures of these metabolites were determined by extensive spectroscopic analysis, including NMR, and HRESIMS. Both compounds were subjected to antibacterial activity tests against antibiotic resistant clinical bacteria, but produced only negligible inhibition
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