94 research outputs found

    Isopropyl(ene)-type Cembrane Diterpene an Important Chemotaxonomical Marker in Bornean Soft Coral Genus Sarcophyton

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    Two cembrane diterpenoids; (+)-11,12-epoxysarcophytol A (1) and sarcophytol W (2) were isolated from Sarcophyton sp. collected from Mantanani Island, Sabah. Secondary metabolites structures were elucidated based on spectroscopic data. This is the first record of cembranoid diterpenes isolated from the Bornean soft coral genus Sarcophyton. The isopropyl(ene)-type cembrane derivatives could be suggested as chemotaxonomical markers for soft coral genus Sarcophyton

    The Chemotaxonomic Identification Using Structure Types of Secondary Metabolites and Their Bioactivities of Bornean Litophyton arboretum

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    The structure types and bioactivities of secondary metabolites derived from Litophyton arboreum, distributed in Sepanggar Bay, Sabah, Malaysia, were investigated as additional tools for establishing their species identification. As a result, a total of two secondary metabolites (alismol (1) and 10ι-methoxy-4βhydroxy guaian-6-ene (2)) were isolated from Bornean soft coral L. arboreum. Their structures were elucidated based on spectroscopic data analysis and the antifungal activities of compounds 1 and 2 were determined. In addition, the compound 2 showed highest antifungal activity against Haliphthoros milfordensis. As a result of comparison with previous literature, significant variations were observed in relation to structure types of secondary metabolites and bioactivities. Information from this study gives additional evidence of chemotaxonomic significance and baseline data for effective selection of suitable lead pharmaceuticals

    Nangallenes A and B, halogenated nonterpenoid C15-acetogenins from the Bornean red alga Laurencia nangii

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    Two new halogenated nonterpenoids C15-acetogenins, nangallenes A-B (1–2), together with two known halogenated compounds itomanallene A (3) and 2,10-dibromo -3-chloro-α- chamigrene (4), were isolated and identified from the organic extract of the marine red alga Laurencia nangii Masuda collected from the coastal waters in Semporna, Borneo. Their structures were established by means of spectroscopic analysis including IR, high-resolution electrospray ionization mass spectrometry (HRESI-MS), and 1D and 2D NMR techniques. All these metabolites were submitted for the antifungal assay against four species of selected marine fungi. Compounds 1–4 showed potent activity against Haliphthoros sabahensis and Lagenidium thermophilum

    Neoiriepentaol and nangenyne, halogenated diterpenoid and C15-acetogenin from red alga Laurencia nangii Masuda collected in Borneo [2018]

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    The red algal genus Laurencia is a prolific producer of halogenated secondary metabolites. A new tricyclic dibrominated diterpenoid, neoiriepentaol (1) and chlorinated C₁₅-acetogenin, nangenyne (2), along with two known terpenoids, neoirietetraol (3) and dactyloxene A (4), were isolated from methanol crude extract of red alga Laurencia nangii. The structures were established based on one- and two-dimensional nuclear magnetic resonance (NMR), Fourier-transform infrared (FTIR), and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. These compounds were screened against seven species of marine fungi. Compounds 1–3 exhibited activity against Lagenidium thermophilum and Haliphthoros sabahensis. Potent activity was showed by 1 with L. thermophilum hyphal inhibition at MIC value of 12.5 μg mL⁻¹ and hyphal motility was observed at 50 μg mL⁻¹ within 24 h

    Capgermacrene C, a New Sesquiterpenoid from a Bornean Soft Coral, Capnella sp.

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    A new bicyclogermacrene, capgermacrene C (1), along with a known compound, 1,4-peroxy-5-muurolene (2), were isolated from a population of Bornean soft coral Capnella sp. The structures of these metabolites were determined by extensive spectroscopic analysis, including NMR, and HRESIMS. Both compounds were subjected to antibacterial activity tests against antibiotic resistant clinical bacteria, but produced only negligible inhibition
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