3 research outputs found
Serum Adiponectin, Visfatin, and Omentin Compared between Non-pregnant and Pregnant Women in Overall, Non-obese, and Obese subjects
Objective: This study aimed to compare serum adiponectin, visfatin, and omentin between non-pregnant and
pregnant women in overall, non-obese, and obese subjects.
Methods: There were 40 pregnant and 33 non-pregnant women classified by body mass index (BMI) into non-obese
or obese subjects. Fasting blood samples were collected in the morning for the non-pregnant group and before
delivery for the pregnant group.
Results: Plasma glucose levels were significantly lower, but plasma insulin levels were significantly higher in pregnant
when compared to non-pregnant women in overall, non-obese, and obese women (p<0.05 all). The homeostasis
model assessment of insulin resistance (HOMA-IR) was significantly higher, but the quantitative insulin sensitivity
check index (QUICKI) was significantly lower only in obese pregnant when compared to obese non-pregnant women
(p<0.01 all). However, in non-obese women, HOMA-IR and QUICKI were comparable between pregnant and
non-pregnant women. Serum adiponectin, visfatin, and omentin were significantly lower in pregnant compared to
non-pregnant women in overall, non-obese, and obese groups (p<0.05 all). In pregnant women, serum adiponectin
and omentin levels were significantly lower in obese compared to non-obese pregnant women while serum visfatin
levels were comparable in both groups. Serum adiponectin levels were highest followed by omentin and visfatin,
respectively in both non-obese and obese pregnant groups. These results indicated that lower serum adiponectin,
visfatin, and omentin in pregnant women might contribute to higher insulin resistance in pregnancy. Furthermore,
serum adiponectin and omentin were reduced in increasing adiposity similarly to non-pregnant women.
Conclusion: Lower serum adiponectin, visfatin, and omentin in pregnant women might lead to decreased insulin
sensitivity in these women
Serum Neuropeptide Y and Leptin Levels compared between Non-pregnant and Pregnant Women in Overall, Non-obese, and Obese Subjects
Objective: The primary objective of this study was to compare serum NPY and leptin levels between non-pregnant
and pregnant women in overall, non-obese, and obese subjects. The secondary objective was to compare these
peptides between non-obese and obese pregnant women.
Methods: Fasting venous blood was collected from non-pregnant women before open abdominal surgery and from
pregnant women when admitted to the delivery room during the latent phase of labor.
Results: There were 12 non-obese and 14 obese subjects in the non-pregnant group and 9 non-obese and 30 obese
subjects in the pregnant group. Systolic blood pressure (SBP) was comparable, but heart rate (HR) was higher in pregnant
compared to non-pregnant women. Mean±S.E.M serum NPY levels were lower in the pregnant than in the non-pregnant
group in overall (0.54±0.02 and 1.34±0.08, respectively), non-obese (0.53±0.05 and 1.23±0.14, respectively), and obese
(0.54±0.03 and 1.43±0.09, respectively) subjects (p<0.01 for all), but these were comparable between obese and non-
obese pregnant subjects. Serum NPY was positively correlated with SBP (R=0.281, p<0.05), but negatively correlated
with HR (R=-0.324, p<0.01). Serum leptin levels were not different between pregnant and non-pregnant groups, but
were significantly higher in obese than non-obese pregnant subjects (p<0.001). Serum leptin levels were positively
correlated with body weight, BMI, waist and hip circumferences in overall and pregnant subjects (p<0.001 all).
Conclusion: In pregnancy, decreased NPY levels might be associated with inhibition of SBP rising as well as increased
HR. Leptin levels might not be associated with pregnancy, but associated mainly with obesity
Insulin Sensitivity and Clinical Profiles in CPP Girls Compared to Controls
Objective: This study aimed to compare obesity, insulin sensitivity, clinical, and metabolic parameters between
CPP and age-matched control girls, with or without obese girls and to determine correlations between these factors.
Methods: CPP and control girls were recruited and were allocated into obese and non-obese groups. There were
3 groups of comparison including non-obese control girls (n=29), non-obese CPP girls (n=20), and obese CPP girls
(n=6), because obese controls could not be recruited.
Results: Body mass index (BMI), body weight, and height percentiles were higher in obese CPP and non-obese CPP
girls compared to control girls. Lipid profiles, glucose, insulin, the homeostasis model assessment-estimated insulin
resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI) were not different between
all groups. Insulin and the HOMA-IR were positively but the QUICKI was negatively correlated with metabolic
and anthropometric parameters mainly in the control group, while these parameters were significantly correlated
with LH and FSH in the CPP group. From multivariate regression, insulin and the HOMA-IR were associated with
reproductive indices in CPP and with fat mass in controls.
Conclusion: Insulin sensitivity and insulin resistance were related to metabolic factors in prepubertal stage, but
were more associated with the reproductive status during pubertal advancement