173 research outputs found
Rationale and design of the United Kingdom Heart Failure with Preserved Ejection Fraction Registry
Raised cardiovascular disease mortality after central nervous system tumour diagnosis:Analysis of 171 926 patients from UK and USA
BACKGROUND: Patients with central nervous system (CNS) tumors may be at risk of dying from cardiovascular disease (CVD). We examined CVD mortality risk in patients with different histological subtypes of CNS tumors. METHODS: We analyzed UK(Wales)-based Secure Anonymized Information Linkage (SAIL) for 8743 CNS tumors patients diagnosed in 2000-2015, and US-based National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) for 163,183 patients in 2005-2015. We calculated age-, sex-, and calendar-year-adjusted standardized mortality ratios (SMRs) for CVD comparing CNS tumor patients to Wales and US residents. We used Cox regression models to examine factors associated with CVD mortality among CNS tumor patients. RESULTS: CVD was the second leading cause of death for CNS tumor patients in SAIL (UK) and SEER (US). Patients with CNS tumors had higher CVD mortality than the general population (SAIL SMR = 2.64, 95% CI = 2.39-2.90, SEER SMR = 1.38, 95% CI = 1.35-1.42). Malignant CNS tumor patients had over 2-fold higher mortality risk in US and UK cohorts. SMRs for nonmalignant tumors were almost 2-fold higher in SAIL than in SEER. CVD mortality risk particularly cerebrovascular disease was substantially greater in patients diagnosed at age younger than 50 years, and within the first year after their cancer diagnosis (SAIL SMR = 2.98, 95% CI = 2.39-3.66, SEER SMR = 2.14, 95% CI = 2.03-2.25). Age, sex, race/ethnicity in USA, deprivation in UK and no surgery were associated with CVD mortality. CONCLUSIONS: Patients with CNS tumors had higher risk for CVD mortality, particularly from cerebrovascular disease compared to the general population, supporting further research to improve mortality outcomes
Longer-term (≥ 2 years) survival in patients with glioblastoma in population-based studies pre- and post-2005:a systematic review and meta-analysis
Cardiovascular events and venous thromboembolism after primary malignant or non-malignant brain tumour diagnosis:A population matched cohort study in Wales (United Kingdom)
Tracking Excess Deaths (TRACKED) – an interactive online tool to monitor excess deaths associated with the COVID-19 pandemic in the United Kingdom
Developing a novel set of quality performance indicators (QPIs) for metastatic bone disease (MBD)
Impact of tumour characteristics and cancer treatment on cerebrovascular mortality after glioma diagnosis: Evidence from a population-based cancer registry
Patient-reported assessment of outcome after surgery for bone metastases:PROMs in metastatic bone disease
Long-term mortality and recurrent vascular events in lacunar versus non-lacunar ischaemic stroke:a cohort study
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